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  1. Myeloablative Unrelated Donor Cord Blood Transplantation With T-Cell Depleted Haplo-identical Peripheral Blood Stem Cells for Patients With High Risk Hematological Malignancies

    ... to CB units that have high TNC (> 5.0 x 10^7/kg), good HLA -match (5/6 or 6/6) and are from good quality CB banks a single unit ... Haploidentical donors who are 5/10 or better but not HLA-identical will be used as outlined in section 6.4. Assignment of ...

    Clinical Trial last updated 04/29/2016 - 1:33pm.

  2. Cord Blood Fucosylation to Enhance Homing and Engraftment in Patients With Hematologic Malignancies

    ... which are matched with the patient at 4, 5, or 6/6 HLA class I (serological) and II (molecular) antigens. Each cord must ...

    Clinical Trial last updated 06/06/2016 - 12:58pm.

  3. Interviews with the Experts Transplantation & GVHD: What Patients Need to Know

    ... our tissue type.  The human leukocyte antigen ( HLA ) is responsible for encoding proteins on cells that help regulate the immune system in humans. HLA’s can be a major cause of organ or stem cell transplant ...

    Interview last updated 09/30/2014 - 11:07am.

  4. Preventing Stem Cell Transplant Complications With a Blood Separator Machine

    ... dendritic cell neoplasm) at first diagnosis 5.1.3 HLA identical (6/6) related donor. 5.1.4 For adults: ability to ...

    Clinical Trial last updated 05/23/2016 - 10:57am.

  5. Personalized Natural Killer (NK) Cell Therapy in Cord Blood Transplantation (CBT)

    ... malignancy. Availability of appropriate, willing, HLA -matched related stem cell donor. ...

    Clinical Trial last updated 06/06/2016 - 10:28am.

  6. Conditioning Regimen and the Transplantation of Unrelated Donor Umbilical Cord Blood in Patients With Hematologic Malignancies.

    ... MSKCC unit selection algorithm. High resolution 8 allele HLA typing will be performed. Unit selection will occur based on 8 allele HLA-match and CD34+ dose. In addition, each unit will have a cryopreserved ...

    Clinical Trial last updated 04/29/2016 - 3:51pm.

  7. IPA Targeted Adoptive Immunotherapy vs Adult Haplo-identical Cell Infusion During Induction of High Risk Leukemia

    ... The unit must match at a minimum of 4 of 6 at HLA-A, -B antigens, -DRB1 alleles with the recipient. Mismatches (0-2) can be ... CBU unit, a match is defined at intermediate resolution for HLA-A and -B and at high resolution for -DRB1. The CBU donor will also have ...

    Clinical Trial last updated 04/29/2016 - 11:05am.