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  1. Azacitidine in Haploidentical Donor Hematopoietic Cell Transplantation

    ... (ALL); however, human leukocyte antigen ( HLA )-matched donor availability continues to be a major hurdle. Historically, HLA haploidentical donor hematopoietic cell transplantation (haplo-HCT) was ...

    Clinical Trial last updated 05/03/2016 - 11:15am.

  2. Cord Blood Transplant

    ... peripheral blood from a Human Leukocyte Antigen ( HLA ) matched sibling donor is the most commonly used source of allogeneic stem cells . However, HLA matched siblings are available for less than one third of the patients who ...

    Clinical Trial last updated 04/27/2016 - 9:59am.

  3. StemRegenin-1 Expanded vs Unexpanded UCB for High Risk Heme Malignancies

    ... Must have a partially HLA matched UCB unit with a pre-cryopreserved TNC dose >2.5 x 107 per kilogram recipient weight. HLA matching is initially based on 4 of 6 HLA-A and B (at low or intermediate ...

    Clinical Trial last updated 06/03/2016 - 2:37pm.

  4. Hematopoietic Stem Cell Transplantation in Aplastic Anemia

    ... best candidates.   For young patients lacking an HLA -matched sibling donor, immunosuppressive therapy (IST) with ... deciding between IST versus transplant is how quickly an HLA-matched donor can be found and cleared for collection. Donor availability ...

    Interview last updated 11/28/2016 - 2:58pm.

  5. Stem Cell Transplant Using Peripheral and Cord Blood Stem Cells to Treat Severe Aplastic Anemia and Myelopdysplastic Syndrome

    ... Allogeneic bone marrow transplantation from either HLA -matched sibling or matched unrelated donor cures about 70 ... rapidity of availability, requirement of less than perfect HLA match, and lower rates of graft versus host disease compared to mismatched ...

    Clinical Trial last updated 04/25/2016 - 2:18pm.

  6. Donor Stem Cell Transplant in Treating Patients With High Risk Acute Myeloid Leukemia

    ... cell transplant (alloSCTx) or not have a known fully HLA matched sibling for planned sibling transplant. Patients must have ... has at least one medically fit family member expected to be HLA mismatched at 1-9/10; more commonly and preferred: 4-6/10 loci (parent, ...

    Clinical Trial last updated 06/13/2016 - 3:31pm.

  7. Bone Marrow Transplantation for Pediatric Patients

    ... with an overview of the transplant process, including HLA matching, protecting your child’s fertility and preparing your child ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  8. CD34+ Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation for Non-Malignant Disease

    ... U. S. Department of Health and Human Services. HLA typing will be performed by high resolution molecular DNA typing for HLA Class I A, B, and C and HLA Class II DRB1 and DQB1 alleles. ...

    Clinical Trial last updated 06/13/2016 - 2:06pm.

  9. Adoptive Transfer of Haplo-identical DLI for AML and MDS

    ... followed by donor lymphocyte infusion (DLI) from HLA -haploidentical donors is a safe procedure that will not cause Graft ... (consolidation) at 1.0 g/m2 for 6 dosages followed by HLA-mismatched DLI after the second consolidation. Biological: DLI HLA-mismatched DLI will be administered Day 9, approximately 24-48 hours ...

    Clinical Trial last updated 05/03/2016 - 9:59am.

  10. Shorter Course Tacrolimus After Nonmyeloablative, Related Donor BMT With High-dose Posttransplantation Cyclophosphamide

    ... 0.5-75 years Suitable first-degree related, HLA haploidentical or HLA-matched donor Eligible diagnoses: a. Low-grade non-Hodgkin's ...

    Clinical Trial last updated 05/02/2016 - 2:38pm.