Search | Aplastic Anemia and MDS International Foundation

Search

Search results

  1. HLA-Matched Sibling Transplantation for Severe Aplastic Anemia: Impact of HLA DR15 Antigen Status on Engraftment, Graft-versus-Host Disease, and Overall Survival.

    ... The HLA class II DRB1 antigen DR15 (common alleles *1501, *1502) is an ... aplastic anemia (SAA). We studied 1204 recipients of HLA-matched sibling bone marrow transplantation for SAA to determine ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia.

    ... commonly involved the human leukocyte antigen ( HLA ) locus, leading to loss of one HLA haplotype. Loss of HLA-A expression from multiple lineages of leukocytes ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Somatic HLA mutations expose the role of class I–mediated autoimmunity in aplastic anemia and its clonal complications

    ... thought to be driven by human leukocyte antigen ( HLA )–restricted T cell immunity, with earlier studies favoring HLA class II-mediated pathways. Using whole-exome sequencing (WES), we recently ...

    Research Article last updated 10/23/2017 - 10:56am.

  4. Current outcome of HLA identical sibling vs. unrelated donor transplants in severe aplastic anemia: an EBMT analysis

    Journal Title:  Haematologica Primary Author:  Bacigalupo A Author(s):  Bacig...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Pilot trial of risk-adapted cyclophosphamide intensity based conditioning and HLA matched sibling and unrelated cord blood stem cell transplantation in newly diagnosed pediatric and adolescent recipients with acquired severe aplastic anemia

    Journal Title:  Pediatr Blood Cancer Primary Author:  McGuinn C Author(s):  M...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Acceptable HLA-mismatching in unrelated donor bone marrow transplantation for patients with acquired severe aplastic anemia

    ... We retrospectively analyzed the impact of HLA mismatching (HLA-A, -B, -C, -DRB1, -DQB1) using molecular typing on transplant outcome for ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Granulocyte transfusions in severe aplastic anemia: an eleven-year experience.

    ... absolute neutrophil count, stratified by HLA alloimmunization status. RESULTS: Thirty-two patients with ... A. One quarter of patients had demonstrable HLA alloimmunization prior to the initiation of granulocyte therapy. ... neutrophil count between the patients divided according to HLA alloimmunization status. CONCLUSIONS: Granulocyte transfusions ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Alternative donor transplantation for aplastic anemia.

    ... who do not have a human leukocyte antigen ( HLA )-identical sibling generally receive immunosuppressive therapy as a ... of Caucasian descent will have an available and fully HLA-matched unrelated adult donor; the rate is substantially lower for ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Non-myeloablative peripheral blood haploidentical stem cell transplantation for refractory severe aplastic anemia

    ... Graft failure was associated with donor-directed HLA antibodies, despite intensive pre-HSCT desensitization with plasma ... rescue refractory SAA patients who lack donor-directed HLA antibodies but not in the presence of donor-directed HLA antibodies. This ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Stem Cell Transplantation From HLA Partially-Matched Related Donors for Patients With Hematologic Malignancies

    ... (HSCT) from Human Leukocyte Antigen ( HLA )-mismatched related donors for children and young adults with ... Available related donor who is mismatched at ≥ 2 HLA alleles Exclusion Criteria:  Available HLA -identical related donor HIV positive Active uncontrolled ...

    Clinical Trial last updated 04/29/2016 - 10:59am.