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Newsstand

Here's where you'll find a regularly updated, broad range of articles written by the AAMDSIF team, allied health organizations and news organizations. By staying well-informed, patients and families are practicing a form of self-support that will help them be more effective self-advocates when engaging with health care providers.

Prognostic value of telomere attrition in patients with aplastic anemia

Originally Published: 07/13/2013
Treatment and outcomes for patients with severe aplastic anemia (SAA) have improved markedly over past 40 years due to advances in hematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy (IST). Nonetheless, these treatments have limitations such as failure to engraft or graft versus host disease for HSCT and lack of response or clonal evolution to myelodysplastic syndrome (MDS) with IST.  Refinements are needed in our treatment algorithms to determine who is best suited to each treatment to minimize these complications. We hope to improve on outcomes further in SAA...

Identification of genetic abnormalities in MDS patients that may lead to a better diagnosis and treatment strategy of MDS patients

Originally Published: 03/29/2013
Myelodysplastic syndrome (MDS) represents a group of diseases that can be subdivided into various categories based on clinical, pathological and certain genetic abnormalities.  Subclassification of MDS, especially in terms of predicted risk for a good or bad outcome, is important because it helps doctors to design a treatment plan. New technologies that can search a patient’s complete genetic information for abnormalities in its code (i.e., DNA) have recently revealed additional genetic abnormalities than can be found on a regular basis in blood cells of MDS patients.  This article reviews...

Myelodysplastic Syndromes are a collection of diseases with common, but also different characteristics

Originally Published: 03/29/2013
Myelodysplastic syndrome (MDS) is not a disease that follows a standard path; especially time of survival after diagnosis and the risk to develop leukemia is highly variable among patients. It is therefore believed that MDS represents not one but a group of diseases.  Indeed, there are several systems in place that allow doctors to classify MDS into particular subtypes based on a pre-determined set of diagnostic criteria; there is the French-American-British (FAB) and the World Health Organization (WHO) classification.  These classification systems describe the cellular nature and genetic...

Even "Moderate" Dose Cyclophosphamide for Severe Aplastic Anemia Is Associated with Significant Toxicities and Does Not Prevent Relapse and Clonal Evolution

Originally Published: 02/25/2013
Note: This review is based upon two presentations at the 2012 American Society of Hematology (ASH) Annual Meeting, December 7-10 in Atlanta, Georgia. The full abstracts may be viewed on the ASH Annual Meeting Web site. Search by entering the title in the search box. The abstract number is referenced to access the full report. Mutations in genes that are key to the telomerase complex can lead to a variety of disorders, including bone marrow failure and liver and lung fibrosis. The lab led by Neal Young at the NHLBI presented two studies at the 2012 American Society of Hematology Meeting in...

Improved Outcome of Reduced Toxicity Fludarabine, Cyclophosphamide Plus Thymoglobulin Conditioning Regimen for Unrelated Donor Transplantation in Severe Aplastic Anemia: Comparison of Two Multicenter Prospective Studies

Originally Published: 02/25/2013
Note: This review is based upon two presentations at the 2012 American Society of Hematology (ASH) Annual Meeting, December 7-10 in Atlanta, Georgia. The full abstracts may be viewed on the ASH Annual Meeting Web site. Search by entering the title in the search box. The abstract number is referenced to access the full report. Mutations in genes that are key to the telomerase complex can lead to a variety of disorders, including bone marrow failure and liver and lung fibrosis. The lab led by Neal Young at the NHLBI presented two studies at the 2012 American Society of Hematology Meeting in...

Clinical and Genetic Heterogeneity of Telomere Diseases

Originally Published: 01/28/2013
Note: This review is based upon two presentations at the 2012 American Society of Hematology (ASH) Annual Meeting, December 7-10 in Atlanta, Georgia. The full abstracts may be viewed on the ASH Annual Meeting Web site. Search by entering the title in the search box. The abstract number is referenced to access the full report. Mutations in genes that are key to the telomerase complex can lead to a variety of disorders, including bone marrow failure and liver and lung fibrosis. The lab led by Neal Young at the NHLBI presented two studies at the 2012 American Society of Hematology Meeting in...

Very Short Telomeres of Peripheral Blood Leukocytes Precede Clinical Progression to Myelodysplasia with Monosomy 7 in Aplastic Anemia Patients

Originally Published: 01/28/2013
Note: This review is based upon two presentations at the 2012 American Society of Hematology (ASH) Annual Meeting, December 7-10 in Atlanta, Georgia. The full abstracts may be viewed on the ASH Annual Meeting Web site. Search by entering the title in the search box. The abstract number is referenced to access the full report. Mutations in genes that are key to the telomerase complex can lead to a variety of disorders, including bone marrow failure and liver and lung fibrosis. The lab led by Neal Young at the NHLBI presented two studies at the 2012 American Society of Hematology Meeting in...

A Rare Genetic Polymorphism in C5 Confers Poor Response to the Anti-C5 Monoclonal Antibody Eculizumab by Nine Japanese Patients with PNH

Originally Published: 01/01/2013
Note: This review is based upon a presentation at the 2012 American Society of Hematology (ASH) Annual Meeting, December 7-10 in Atlanta, Georgia.The full abstract may be reviewed on the ASH Annual Meeting Web site. Search by entering the title in the search box. The abstract number is referenced to access the full report. Oral Presentation Abstract #3197  Rafael Bejar, Kristen E. Stevenson, Petar Stojanov, J. Eric Zaneveld, Michal Bar-Natan, Bennett Caughey, Hui Wang, Guillermo Garcia-Manero, Hagop M. Kantarjian, Corey Cutler, Jerome Ritz, Kristian Cibulskis, Gad Getz, David P. Steensma...

Autoreactive T Cells From Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Specifically Recognize Glycosyl- Phosphatidyl-Inositol (GPI)

Originally Published: 01/01/2013
Note: This review is based upon a presentation at the 2012 American Society of Hematology (ASH) Annual Meeting, December 7-10 in Atlanta, Georgia.The full abstract may be reviewed on the ASH Annual Meeting Web site. Search by entering the title in the search box. The abstract number is referenced to access the full report. Abstract Number #647 Oral Presentation Lucia Gargiulo, Michela Sica, Maria Papaioannou, Giulia Talini, Aristeidis Chaidos, Barbara Richichi, Andrei V Nikolaev, Cristina Nativi, Mark Layton, Josu de la Fuente, Irene Roberts, Lucio Luzzatto, Rosario Notaro, and Anastasios...

Detection of Recurrent Mutations by Pooled Targeted Next-Generation Sequencing in MDS Patients Prior to Treatment with Hypomethylating Agents or Stem Cell Transplantation

Originally Published: 01/01/2013
Note: This review is based upon a presentation at the 2012 American Society of Hematology (ASH) Annual Meeting, December 7-10 in Atlanta, Georgia.The full abstract may be reviewed on the ASH Annual Meeting Web site. Search by entering the title in the search box. The abstract number is referenced to access the full report. Abstract #311 Rafael Bejar, MD, PhD1, Kristen E. Stevenson, MS2, Petar Stojanov3, J. Eric Zaneveld4, Michal Bar-Natan5, Bennett Caughey6, Hui Wang, Ph.D.7, Guillermo Garcia-Manero, MD8, Hagop M. Kantarjian, MD9, Corey Cutler, MD, MPH, FRCPC10, Jerome Ritz, MD11,...