Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies | Aplastic Anemia and MDS International Foundation

Clinical Trial: NCT01760655

Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies
For more details on this clinical trial, including contact information, please see this trial’s listing on clinicaltrials.gov:
Purpose: 

This clinical trial studies reduced-intensity conditioning before donor stem cell transplant in treating patients with high-risk hematologic malignancies. Giving low-doses of chemotherapy and total-body irradiation before a donor stem cell transplant helps stop the growth of cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Giving an infusion of the donor's T cells (donor lymphocyte infusion) after the transplant may help increase this effect.

Status: 
Recruiting
Study Date: 
Sat, 12/01/2012 to Mon, 01/01/2018
Bone Marrow Disease(s): 
myelodysplastic syndromes (MDS)
Intervention: 
Drug: Fludarabine phosphate Given IV Other Names: Fludarabine Fludara Drug: Thiotepa Given IV Other Names: N,N'N'-triethylenethiophosphoramide 1,1',1''-phosphorothioyltriaziridine Radiation: Total body irradiation Undergo TBI Other Name: TBI Biological: Therapeutic allogeneic lymphocytes Undergo donor lymphocyte infusion Other Names: Allogeneic Lymphocytes ALLOLYMPH Drug: Cyclophosphamide Given IV Other Names: Endoxan Cytoxan Neosar Procytox Revimmune (RS)-N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide Lyophilizedcytoxan Procedure: Allogeneic hematopoietic stem cell transplantation (HSCT) Undergo allogeneic PBSCT Procedure: Peripheral blood stem cell transplantation Undergo allogeneic PBSCT Other Names: PBPC transplantation PBSC transplantation peripheral blood progenitor cell transplantation Drug: Tacrolimus Given IV Other Names: FK-506 fujimycin Prograf Advagraf Protopic Drug: Mycophenolate mofetil Given IV Other Names: MMF CellCept Myfortic