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  1. Hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: long-term results of a retrospective study on behalf of the Gruppo Italiano Trapianto Midollo Osseo (GITMO).

    ... donors were HLA -identical (22 siblings and one unrelated) and 3 were HLA-mismatched (2 related and one unrelated). ... and cyclophosphamide (in all cases from identical donor) and 11 were given a reduced intensity conditioning (8 from identical ...

    Research Article last updated 10/11/2011 - 5:58pm.

  2. Blood stream infection after stem cell transplantation in children with idiopathic aplastic anemia

    ... therapy with anti-thymocyte globulin, transplantation from unrelated donors, frequent blood transfusion before transplantation, ... in patients who were transplanted from an unrelated donor , control of BSI is very important for success of HSCT in patients ...

    Research Article last updated 04/23/2014 - 10:34am.

  3. Transplantation strategies for the management of patients with myelodysplastic syndromes.

    ... CST replaces recipient dysplastic hemopoiesis with healthy donor haemopoiesis and immune system with an attendant graft-versus-leukemia ... in patients with high-risk MDS. Allogeneic SCT from matched unrelated donors produce poorer results than matched related siblings' ...

    Research Article last updated 10/11/2011 - 5:58pm.

  4. Total Lymphoid Irradiation-Antithymocyte Globulin Conditioning and Allogeneic Transplantation for Patients with Myelodysplastic Syndromes and Myeloproliferative Neoplasms

    ... globulin (ATG) permits the establishment of donor hematopoiesis necessary for the graft-versus-malignancy effect ... between patients who received allografts from related or unrelated donors. The cumulative incidence of nonrelapse mortality (NRM) at ...

    Research Article last updated 04/17/2014 - 11:48am.

  5. Clinical management of aplastic anemia.

    ... of choice for young patients who have a matched sibling donor. Immunosuppression with either anti-thymocyte globulin and ... to age or lack of a suitable donor. Results of BMT from unrelated and mismatched donors are improving, but presently this treatment ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. New therapeutic approaches for protecting hematopoietic stem cells in aplastic anemia.

    ... targets self-reactive T cells, or (2) matched sibling or unrelated BM transplant (BMT). The IST treatment is often not effective due to ... to their age, comorbidities, and the lack of histocompatible donor. This necessitates development and testing of novel approaches to reduce ...

    Research Article last updated 11/14/2013 - 11:18am.

  7. Hematopoietic stem cell transplantation with umbilical cord multipotent stromal cell infusion for the treatment of aplastic anemia-a single-center experience.

    ... human leukocyte antigen -matched related (six cases) and unrelated donors (eight cases). MSCs were intravenously infused at a mean dose ... 15 months; they are transfusion-independent and reached full donor chimerism at the time of reporting. CONCLUSIONS: UC-MSC infusion ...

    Research Article last updated 07/09/2013 - 2:48pm.

  8. Alemtuzumab with fludarabine and cyclophosphamide reduces chronic graft versus host disease after allogeneic stem cell transplantation for acquired aplastic anemia.

    ... transplanted from matched sibling donors (MSD) (n=21) and unrelated donors, UD (n=29), using fludarabine 30mg/m(2) for 4 days, ... graft failure was 9.5% for MSD and 14.5% for UD HCT. Full donor chimerism (FDC) in unfractionated peripheral blood was 42%; no patient ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. Allo HSCT Using RIC for Hematological Diseases

    ... (TBI) preparative regimen followed by a related or unrelated donor stem cell infusion. The primary objective is to evaluate rates of ...

    Clinical Trial last updated 05/02/2016 - 9:29am.

  10. Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

    ... did not occur, with all patients achieving complete donor lymphohematopoietic chimerism. Unfortunately, recipients of G-CSF ... from an HLA identical sibling or match unrelated donor using the identical conditioning regimen utilized in ... HLA locus mismatched family donor or 10/10 matched unrelated donor at the allelic level (HLA alleles A, B, C, DR, and DQ). ...

    Clinical Trial last updated 04/28/2016 - 2:40pm.