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  1. Clinical management of aplastic anemia.

    ... of choice for young patients who have a matched sibling donor. Immunosuppression with either anti-thymocyte globulin and ... to age or lack of a suitable donor. Results of BMT from unrelated and mismatched donors are improving, but presently this treatment ...

    Research Article last updated 10/11/2011 - 5:58pm.

  2. Hematopoietic Stem Cell Transplantation in Aplastic Anemia

    ... with marked improvements in outcomes for unrelated donor transplants. When considering treatments for newly diagnosed aplastic ... impair their quality of life. Recently, the outcomes of unrelated donor transplantation have markedly improved. Previously, there was a ...

    Interview last updated 11/28/2016 - 2:58pm.

  3. Total Lymphoid Irradiation-Antithymocyte Globulin Conditioning and Allogeneic Transplantation for Patients with Myelodysplastic Syndromes and Myeloproliferative Neoplasms

    ... globulin (ATG) permits the establishment of donor hematopoiesis necessary for the graft-versus-malignancy effect ... between patients who received allografts from related or unrelated donors. The cumulative incidence of nonrelapse mortality (NRM) at ...

    Research Article last updated 04/17/2014 - 11:48am.

  4. New therapeutic approaches for protecting hematopoietic stem cells in aplastic anemia.

    ... targets self-reactive T cells, or (2) matched sibling or unrelated BM transplant (BMT). The IST treatment is often not effective due to ... to their age, comorbidities, and the lack of histocompatible donor. This necessitates development and testing of novel approaches to reduce ...

    Research Article last updated 11/14/2013 - 11:18am.

  5. Reduced Intensity Conditioning in Patients Aged ≤35 With Non-Malignant Disorders Undergoing UCBT, BMT, or PBSCT (RIC HSCT NMD)

    ... condition regimen with UCBT, double cord UCBT, matched unrelated donor (MUD) bone marrow transplant (BMT) or peripheral blood ...

    Clinical Trial last updated 06/13/2016 - 2:18pm.

  6. Hematopoietic stem cell transplantation with umbilical cord multipotent stromal cell infusion for the treatment of aplastic anemia-a single-center experience.

    ... human leukocyte antigen -matched related (six cases) and unrelated donors (eight cases). MSCs were intravenously infused at a mean dose ... 15 months; they are transfusion-independent and reached full donor chimerism at the time of reporting. CONCLUSIONS: UC-MSC infusion ...

    Research Article last updated 07/09/2013 - 2:48pm.

  7. Alemtuzumab with fludarabine and cyclophosphamide reduces chronic graft versus host disease after allogeneic stem cell transplantation for acquired aplastic anemia.

    ... transplanted from matched sibling donors (MSD) (n=21) and unrelated donors, UD (n=29), using fludarabine 30mg/m(2) for 4 days, ... graft failure was 9.5% for MSD and 14.5% for UD HCT. Full donor chimerism (FDC) in unfractionated peripheral blood was 42%; no patient ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. Myeloablative Unrelated Donor Cord Blood Transplantation With T-Cell Depleted Haplo-identical Peripheral Blood Stem Cells for Patients With High Risk Hematological Malignancies

    ... or both units 1.5-1.9 x 10^7/kg.   Haploidentical Donor Inclusion Criteria: A HLA-haploidentical related donor will be selected as available Mismatched family members who are matched ...

    Clinical Trial last updated 04/29/2016 - 1:33pm.

  9. Unrelated Donor Stem Cell Transplantation

    ... bone marrow failure states who lack a suitable sibling donor to undergo allogeneic hematopoietic progenitor cell transplantation using cells from unrelated individuals or cord blood registries. ...

    Clinical Trial last updated 04/27/2016 - 3:18pm.

  10. Unrelated Donor Stem Cell Transplantation

    ... bone marrow failure states who lack a suitable sibling donor to undergo allogeneic hematopoietic progenitor cell transplantation using cells from unrelated individuals or cord blood registries. ...

    Clinical Trial last updated 04/28/2016 - 2:16pm.