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  1. Transplantation strategies for the management of patients with myelodysplastic syndromes.

    ... CST replaces recipient dysplastic hemopoiesis with healthy donor haemopoiesis and immune system with an attendant graft-versus-leukemia ... in patients with high-risk MDS. Allogeneic SCT from matched unrelated donors produce poorer results than matched related siblings' ...

    Research Article last updated 10/11/2011 - 5:58pm.

  2. Myeloablative Unrelated Donor Cord Blood Transplantation With T-Cell Depleted Haplo-identical Peripheral Blood Stem Cells for Patients With High Risk Hematological Malignancies

    ... or both units 1.5-1.9 x 10^7/kg.   Haploidentical Donor Inclusion Criteria: A HLA-haploidentical related donor will be selected as available Mismatched family members who are matched ...

    Clinical Trial last updated 04/29/2016 - 1:33pm.

  3. Unrelated Donor Stem Cell Transplantation

    ... bone marrow failure states who lack a suitable sibling donor to undergo allogeneic hematopoietic progenitor cell transplantation using cells from unrelated individuals or cord blood registries. ...

    Clinical Trial last updated 04/27/2016 - 3:18pm.

  4. Unrelated Donor Stem Cell Transplantation

    ... bone marrow failure states who lack a suitable sibling donor to undergo allogeneic hematopoietic progenitor cell transplantation using cells from unrelated individuals or cord blood registries. ...

    Clinical Trial last updated 04/28/2016 - 2:16pm.

  5. Clinical management of aplastic anemia.

    ... of choice for young patients who have a matched sibling donor. Immunosuppression with either anti-thymocyte globulin and ... to age or lack of a suitable donor. Results of BMT from unrelated and mismatched donors are improving, but presently this treatment ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. Total Lymphoid Irradiation-Antithymocyte Globulin Conditioning and Allogeneic Transplantation for Patients with Myelodysplastic Syndromes and Myeloproliferative Neoplasms

    ... globulin (ATG) permits the establishment of donor hematopoiesis necessary for the graft-versus-malignancy effect ... between patients who received allografts from related or unrelated donors. The cumulative incidence of nonrelapse mortality (NRM) at ...

    Research Article last updated 04/17/2014 - 11:48am.

  7. New therapeutic approaches for protecting hematopoietic stem cells in aplastic anemia.

    ... targets self-reactive T cells, or (2) matched sibling or unrelated BM transplant (BMT). The IST treatment is often not effective due to ... to their age, comorbidities, and the lack of histocompatible donor. This necessitates development and testing of novel approaches to reduce ...

    Research Article last updated 11/14/2013 - 11:18am.

  8. Hematopoietic stem cell transplantation with umbilical cord multipotent stromal cell infusion for the treatment of aplastic anemia-a single-center experience.

    ... human leukocyte antigen -matched related (six cases) and unrelated donors (eight cases). MSCs were intravenously infused at a mean dose ... 15 months; they are transfusion-independent and reached full donor chimerism at the time of reporting. CONCLUSIONS: UC-MSC infusion ...

    Research Article last updated 07/09/2013 - 2:48pm.

  9. Alemtuzumab with fludarabine and cyclophosphamide reduces chronic graft versus host disease after allogeneic stem cell transplantation for acquired aplastic anemia.

    ... transplanted from matched sibling donors (MSD) (n=21) and unrelated donors, UD (n=29), using fludarabine 30mg/m(2) for 4 days, ... graft failure was 9.5% for MSD and 14.5% for UD HCT. Full donor chimerism (FDC) in unfractionated peripheral blood was 42%; no patient ...

    Research Article last updated 10/11/2011 - 5:58pm.

  10. Non-Myeloablative Conditioning for Unrelated Donor Umbilical Cord Blood Transplant

    ... radiation therapy. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. Giving ... an available 5-6/6 HLA -A, B, DRB1 matched sibling donor Pregnancy or breastfeeding Evidence of human immunodeficiency ...

    Clinical Trial last updated 05/02/2016 - 2:13pm.