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  1. Optimization of therapy for severe aplastic anemia based on clinical, biologic, and treatment response parameters: conclusions of an international working group on severe aplastic anemia convened by the Blood and Marrow Transplant Clinical Trials Network.

    ... should be developed; (4) innovative approaches to unrelated donor BMT that decrease graft-versus-host disease are needed; and (5) ...

    Research Article last updated 10/11/2011 - 5:58pm.

  2. Late Effects in Hematopoietic Cell Transplant Recipients with Acquired Severe Aplastic Anemia: A Report from the Late Effects Working Committee of the Center for International Blood and Marrow Transplant Research

    ... (68.5%) and 542 (31.5%) patients underwent a matched sibling donor (MSD) or unrelated donor (URD) HCT, respectively. The median age at the time of HCT ...

    Research Article last updated 10/01/2012 - 9:20am.

  3. Optimizing Cord Blood and Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502) (CHAMP)

    ... simultaneous, parallel phase II study with one arm receiving unrelated cord blood transplantation and the other arm receiving haploidentical ... at high resolution using DNA-based typing) or unrelated donor (8/8 match for HLA-A, B, C, and DRB1 at high resolution using ...

    Clinical Trial last updated 12/19/2017 - 7:55am.

  4. Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant

    ... patients with hematologic malignancies undergoing unrelated donor peripheral blood stem cell transplant . Giving chemotherapy and total-body irradiation before a donor peripheral blood stem cell transplant (PBSCT) helps stop the growth of ...

    Clinical Trial last updated 04/28/2016 - 1:49pm.

  5. Azacitidine in Patients Undergoing Matched Unrelated Stem Cell Transplantation

    ... the effect on grade II-IV GvHD when given after matched unrelated donor transplant (MUD). ...

    Clinical Trial last updated 05/02/2016 - 2:07pm.

  6. Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

    ... transplantation (SCT), stem cells are taken from a donor and given to a recipient. Sometimes the recipient s immune system ... improves the results of allogeneic SCT from HLA-matched unrelated donors. Objective: - To see if high doses of palifermin ...

    Clinical Trial last updated 04/29/2016 - 1:00pm.

  7. Conditioning Regimen and the Transplantation of Unrelated Donor Umbilical Cord Blood in Patients With Hematologic Malignancies.

    ... The traditional way of doing a donor transplant is to give high doses of chemotherapy and radiation ... with no available and suitably matched related or unrelated donor . Acute myelogenous leukemia (AML): Complete ...

    Clinical Trial last updated 04/29/2016 - 3:51pm.

  8. Improved Outcome of Reduced Toxicity Fludarabine, Cyclophosphamide Plus Thymoglobulin Conditioning Regimen for Unrelated Donor Transplantation in Severe Aplastic Anemia: Comparison of Two Multicenter Prospective Studies

    ... being prepared for bone marrow transplantation with an unrelated donor .  The treatment-related mortalities were compared between two ...

    Research Review last updated 05/02/2016 - 9:24am.

  9. Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders

    ... together with fludarabine phosphate followed by a donor peripheral stem cell transplant in treating patients with ... ( HLA )-identical related or an HLA-matched unrelated donor (Fred Hutchinson Cancer Research Center [FHCRC] matching ...

    Clinical Trial last updated 04/28/2016 - 2:45pm.

  10. Hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: long-term results of a retrospective study on behalf of the Gruppo Italiano Trapianto Midollo Osseo (GITMO).

    ... donors were HLA -identical (22 siblings and one unrelated) and 3 were HLA-mismatched (2 related and one unrelated). ... and cyclophosphamide (in all cases from identical donor) and 11 were given a reduced intensity conditioning (8 from identical ...

    Research Article last updated 10/11/2011 - 5:58pm.