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  1. Biomarkers for predicting clinical response to immunosuppressive therapy in aplastic anemia

    ... of a human leukocyte antigen ( HLA )-matched donor. Although IST is a promising treatment option, the ability to predict its ... AA patients, including up-front HSCT from HLA-matched unrelated donor . The present review summarizes studies evaluating the ...

    Research Article last updated 06/22/2016 - 10:19am.

  2. Current Outcome of HLA Identical Sibling vs Unrelated Donor Transplants in Severe Aplastic Anemia: An EBMT Analysis

    ... markers as the patient. HSCT from an HLA-matched, unrelated donor appears to have poorer outcomes than from a matched sibling donor. ...

    Research Review last updated 05/02/2016 - 9:20am.

  3. Strong results for SAA patients at Johns Hopkins

    ... every cell in the body. In an effort to overcome the donor shortage and offer transplant to more patients, DeZern, Brodsky and their ... and willing donor who was a half match. Three patients used unrelated donors. After administering a cocktail of drugs designed to ...

    Article last updated 02/07/2017 - 11:05am.

  4. How I treat acquired aplastic anemia

    ... (BMT) , is the other therapeutic option: a matched sibling donor remains the best choice. For patients lacking a matched family donor, unrelated donors can be readily found, although mostly for patients of ...

    Research Article last updated 02/03/2017 - 9:51am.

  5. Bone Marrow Transplantation for Acquired Severe Aplastic Anemia

    ... ongoing progress in the use of SAA in the setting of unrelated donor transplants, which now provide outcomes similar, though still not ...

    Research Article last updated 01/20/2015 - 2:47pm.

  6. Aplastic anemia: therapeutic updates in immunosuppression and transplantation

    ... in the matched setting, but with greater rates observed with unrelated and umbilical cord donors. The correlation of increasing age with the ... in adults with SAA. Outcomes with matched unrelated donor HSCT have improved, likely due to better donor selection, ...

    Research Article last updated 01/02/2013 - 2:25pm.

  7. Impact of donor source on hematopoietic cell transplantation outcomes for patients with myelodysplastic syndromes (MDS)

    ... leukocyte antigen ( HLA ) matched related donor (MRD) and matched unrelated donors (MUD) produces similar survival for patients with acute ...

    Research Article last updated 08/06/2013 - 2:12pm.

  8. Hematopoietic stem cell transplantation for aplastic anemia and paroxysmal nocturnal hemoglobinuria: current evidence and recommendations

    ... is the preferred option for young AA patients with a sibling donor, whereas in older patients or in those to be grafted from an unrelated donor BMT is exploited as second-line treatment. Current results of ...

    Research Article last updated 11/03/2014 - 10:22am.

  9. Allogeneic haematopoietic stem cell transplantation in myelodysplastic syndromes

    ... human leukocyte antigen -identical sibling or match unrelated donor options. A preemptive management approach to patients at high risk ...

    Research Article last updated 09/24/2014 - 10:46am.

  10. The diagnosis and treatment of aplastic anemia: a review

    ... therapy for patients <40 years when a matched sibling donor (MSD) is not available for transplant. MSD hematopoietic stem cell ... but a response rate of about 60 %. Front-line matched unrelated donor (MUD) appears to be a viable option in children with ...

    Research Article last updated 05/26/2015 - 10:30am.