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  1. Conditioning Regimen and the Transplantation of Unrelated Donor Umbilical Cord Blood in Patients With Hematologic Malignancies.

    ... The traditional way of doing a donor transplant is to give high doses of chemotherapy and radiation ... with no available and suitably matched related or unrelated donor . Acute myelogenous leukemia (AML): Complete ...

    Clinical Trial last updated 04/29/2016 - 3:51pm.

  2. Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

    ... physician immediately Research participants must have a donor or stem cell source identified for allogeneic transplantation, either related (7/8 or 8/8 allele matched or haploidentical), unrelated (7/8 or 8/8 allele match) donor, or cord blood stem cell source (at ...

    Clinical Trial last updated 07/14/2016 - 4:08pm.

  3. Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders

    ... together with fludarabine phosphate followed by a donor peripheral stem cell transplant in treating patients with ... ( HLA )-identical related or an HLA-matched unrelated donor (Fred Hutchinson Cancer Research Center [FHCRC] matching ...

    Clinical Trial last updated 04/28/2016 - 2:45pm.

  4. Transplantation of Partially Mismatched Related or Matched Unrelated Bone Marrow for Patients With Refractory Severe Aplastic Anemia

    ... or ethnic background. Prior transfusions from selected donor (as this could have cause recipient alloimmunization against the donor) Women of childbearing potential who currently are pregnant (HCG+) or ...

    Clinical Trial last updated 06/06/2016 - 2:42pm.

  5. Donor Lymphocyte Infusion (DLI) of T-cells Genetically Modified With iCasp9 Suicide Gene

    ... designed to block participant's body's ability to reject the donor's stem cells . Researchers also want to learn if giving AP1903 ... -matched for HLA-A, -B, C and DR matched or, b. Matched Unrelated Donor (MUD), 8/8 HLA-matched for HLA A, B, C and DRB1 using ...

    Clinical Trial last updated 06/06/2016 - 12:41pm.

  6. Myeloablative Unrelated Donor Cord Blood Transplantation With T-Cell Depleted Haplo-identical Peripheral Blood Stem Cells for Patients With High Risk Hematological Malignancies

    ... or both units 1.5-1.9 x 10^7/kg.   Haploidentical Donor Inclusion Criteria: A HLA-haploidentical related donor will be selected as available Mismatched family members who are matched ...

    Clinical Trial last updated 04/29/2016 - 1:33pm.

  7. Unrelated Donor Stem Cell Transplantation

    ... bone marrow failure states who lack a suitable sibling donor to undergo allogeneic hematopoietic progenitor cell transplantation using cells from unrelated individuals or cord blood registries. ...

    Clinical Trial last updated 04/28/2016 - 2:16pm.

  8. Non-Myeloablative Conditioning for Unrelated Donor Umbilical Cord Blood Transplant

    ... radiation therapy. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. Giving ... an available 5-6/6 HLA -A, B, DRB1 matched sibling donor Pregnancy or breastfeeding Evidence of human immunodeficiency ...

    Clinical Trial last updated 05/02/2016 - 2:13pm.

  9. Unrelated Donor Stem Cell Transplantation

    ... bone marrow failure states who lack a suitable sibling donor to undergo allogeneic hematopoietic progenitor cell transplantation using cells from unrelated individuals or cord blood registries. ...

    Clinical Trial last updated 04/27/2016 - 3:18pm.

  10. Stem Cell Transplant from Unrelated Donor in Patients with Severe Aplastic Anemia: Indications, Donor Selection, Conditioning, GVHD Prophylaxis

    ... younger than 40 years, with a HLA identical sibling donor. For patients older than 40 years, IST was the only therapeutic option. ... two decades, the improved results in the setting of unrelated donor (UD) transplantation have allowed us to introduce UD HSCT ...

    Research Article last updated 03/03/2015 - 11:27am.