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  1. The prognostic value of serum c-reactive protein, ferritin, and albumin prior to allogeneic transplantation for acute myeloid leukemia and myelodysplastic syndromes

    ... or myelodysplastic syndromes undergoing unrelated donor transplant reported to the Center for International Blood and Marrow ...

    Research Article last updated 10/06/2016 - 11:27am.

  2. First-in Human Clinical Transplant Trial for Severe Aplastic Anemia

    ... for patients who lack an HLA identical sibling or unrelated donors. This work that we began aimed at helping patients that did not have an HLA matched donor started about 12 years ago. This is when we tried to come up with a ...

    Interview last updated 10/04/2017 - 1:36pm.

  3. Strong results for SAA patients at Johns Hopkins

    ... every cell in the body. In an effort to overcome the donor shortage and offer transplant to more patients, DeZern, Brodsky and their ... and willing donor who was a half match. Three patients used unrelated donors. After administering a cocktail of drugs designed to ...

    Article last updated 02/07/2017 - 11:05am.

  4. How I treat acquired aplastic anemia

    ... (BMT) , is the other therapeutic option: a matched sibling donor remains the best choice. For patients lacking a matched family donor, unrelated donors can be readily found, although mostly for patients of ...

    Research Article last updated 02/03/2017 - 9:51am.

  5. Evolving hematopoietic stem cell transplantation strategies in severe aplastic anemia

    ... PURPOSE OF REVIEW: Significant improvements in unrelated donor hematopoietic stem cell transplantation (HSCT) in recent years have ...

    Research Article last updated 04/29/2016 - 10:19am.

  6. Is it time for a change? The case for early application of unrelated allo-SCT for severe aplastic anemia.

    ... curative option. Its application remains limited by donor availability and by the potential for treatment-related morbidity and mortality. The improved outcomes with unrelated transplantation are a result of the advent of molecular ... registry. Decision making regarding the earlier use of unrelated transplant procedures is rapidly evolving. This paper reviews ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Pilot trial of risk-adapted cyclophosphamide intensity based conditioning and HLA matched sibling and unrelated cord blood stem cell transplantation in newly diagnosed pediatric and adolescent recipients with acquired severe aplastic anemia

    ... patients with acquired SAA incorporating alternative donor sources, including cord blood. Average risk for non- engraftment ... included MRD BM (6/6 [n = 9], 5/6 [n = 2]) and unrelated CB (5/6 [n = 4], 4/6 [n = 2]). Five year OS was 67.6% ...

    Research Article last updated 04/09/2014 - 9:11am.

  8. Biomarkers for predicting clinical response to immunosuppressive therapy in aplastic anemia

    ... of a human leukocyte antigen ( HLA )-matched donor. Although IST is a promising treatment option, the ability to predict its ... AA patients, including up-front HSCT from HLA-matched unrelated donor . The present review summarizes studies evaluating the ...

    Research Article last updated 06/22/2016 - 10:19am.

  9. Reduced dose cyclophosphamide, fludarabine and antithymocyte globulin for sibling and unrelated transplant of children with severe and very severe aplastic anemia.

    ... disease severity (SAA vs. VSAA, p = 0.184), or according to donor type (MSD vs. UD, p = 0.699). Excellent outcomes of patients with VSAA ...

    Research Article last updated 05/14/2013 - 1:00pm.

  10. Allogeneic transplantation for aplastic anemia

    ... severe aplastic anemia, HLA -matched sibling, unrelated donor , hematopoietic stem cell transplantation. RESULTS: Survival ...

    Research Article last updated 07/03/2012 - 2:57pm.