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  1. The clinical, quality of life, and economic consequences of chronic anemia and transfusion support in patients with myelodysplastic syndromes

    ... chronic anemia and red blood cell (RBC) transfusion dependence impact negatively on survival and quality of life (QoL), ... have been shown to be effective in achieving transfusion independence by altering the natural course of MDS. ...

    Research Article last updated 06/15/2012 - 2:03pm.

  2. Interim analysis of post-marketing surveillance of eculizumab for paroxysmal nocturnal hemoglobinuria in Japan

    ... change in hemoglobin (Hb) level, the withdrawal of transfusion and corticosteroids, the change of renal function, and overall ... An increase in Hb and a high rate of transfusion independence were observed, especially in patients with platelet ...

    Research Article last updated 11/02/2016 - 10:39am.

  3. Randomized Phase III Study of Lenalidomide Versus Placebo in RBC Transfusion-Dependent Patients With Lower-Risk Non-del(5q) Myelodysplastic Syndromes and Ineligible for or Refractory to Erythropoiesis-Stimulating Agents

    ... the efficacy and safety of lenalidomide in RBC transfusion-dependent patients with International Prognostic Scoring System ... The primary end point was the rate of RBC transfusion independence (TI) ≥ 8 weeks. Secondary end points were RBC-TI ≥ 24 ...

    Research Article last updated 07/18/2016 - 10:30am.

  4. Lenalidomide performance in the real world: Patterns of use and effectiveness in a Medicare population with myelodysplastic syndromes.

    ... is approved for the treatment of anemia with transfusion dependence (TD) in patients with lower-risk myelodysplastic ... transfusion user (TU), 1 transfusion; and transfusion independence (TI), no transfusions. RESULTS: A total of 753 of ...

    Research Article last updated 08/15/2013 - 9:50am.

  5. Interim analysis of post-marketing surveillance of eculizumab for paroxysmal nocturnal hemoglobinuria in Japan

    ... change in hemoglobin (Hb) level, the withdrawal of transfusion and corticosteroids, the change of renal function, and overall ... An increase in Hb and a high rate of transfusion independence were observed, especially in patients with platelet ...

    Research Article last updated 08/15/2016 - 9:10am.

  6. A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with del5q

    ... the efficacy and safety of lenalidomide in 205 RBC transfusion-dependent patients with IPSS Low-/Intermediate-1-risk del5q31 ... 10- and 5-mg groups achieved RBC- transfusion independence (TI) for ≥ 26 weeks (primary endpoint) versus placebo (56.1% ...

    Research Article last updated 07/28/2014 - 9:04am.

  7. The immunomodulatory agents lenalidomide and thalidomide for treatment of the myelodysplastic syndromes: A clinical practice guideline.

    ... the aging population. Treatment includes red blood cell transfusion for anemia . The immunomodulatory agents (imids) ... and lenalidomide may induce transfusion independence . This guideline systematically reviews evidence on imids to ...

    Research Article last updated 10/01/2012 - 10:04am.

  8. Does addition of erythropoiesis stimulating agents improve the outcome of higher-risk myelodysplastic syndromes treated with azacitidine?

    ... patients reached HI-E (p=0.07); 48% and 20% achieved transfusion independence (p=0.01). Median OS was 19.6months in the ESA and 11.9months ...

    Research Article last updated 07/28/2014 - 9:30am.

  9. Patients with Myelodysplastic Syndromes Treated with Azacitidine in Clinical Practice: The AVIDA® Registry

    ... treatment decisions. Hematologic improvement (HI) and transfusion independence (TI) assessments used IWG-2000 criteria. Enrolled were 421 ...

    Research Article last updated 07/07/2014 - 9:42am.

  10. Long-term follow-up of patients with moderate aplastic anemia and pure red cell aplasia treated with daclizumab.

    ... achieved long-term packed red blood cell PRBC transfusion independence , and all PRCA responders achieved long-term transfusion PRBC ...

    Research Article last updated 10/11/2011 - 5:58pm.