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  1. Early treatment initiation in lower-risk myelodysplastic syndromes produces an earlier and higher rate of transfusion independence

    ... transfusions can improve anemia ; however, prolonged transfusion dependence (TD) is associated with increased morbidity and ... start of TD) on the likelihood of achieving transfusion independence (TI) among 508 TD patients with MDS. Mean time to DMT was ...

    Research Article last updated 09/13/2017 - 8:58am.

  2. FDA approves new drug for relapsed or refractory AML

    ... recovery (CRh) rates, CR/CRh duration, and conversion from transfusion dependence to transfusion independence were the basis of approval. After a median follow-up time ...

    Article last updated 08/30/2017 - 8:30am.

  3. Patterns of treatment and costs associated with transfusion burden in patients with myelodysplastic syndromes.

    ... May 9, 2017 Transfusion dependence (TD) among myelodysplastic syndromes (MDS) ... cost patterns of MDS care during TD and transfusion independence (TI). MDS patients were identified from a US claims database ...

    Research Article last updated 05/22/2017 - 11:01am.

  4. Efficacy, safety, and pharmacokinetics of subcutaneous azacitidine in Taiwanese patients with higher-risk myelodysplastic syndromes

    ... hematologic improvement, 12 of 32 patients attained RBC transfusion independence and 7 of 18 attained platelet transfusion ...

    Research Article last updated 02/03/2017 - 10:05am.

  5. Association between Transfusion Status and Overall Survival in Patients with Myelodysplastic Syndromes: A Systematic Literature Review and Meta-Analysis

    ... INTRODUCTION: Multiple studies show that transfusion independence (TI) in myelodysplastic syndrome (MDS) has a positive impact ...

    Research Article last updated 06/23/2016 - 10:11am.

  6. Lenalidomide use in myelodysplastic syndromes: Insights into the biologic mechanisms and clinical applications

    ... of chromosome 5 (5q-), where it leads to high rates of transfusion independence and cytogenetic responses. Furthermore, lenalidomide delays ...

    Research Article last updated 02/21/2017 - 9:34am.

  7. How I treat acquired aplastic anemia

    ... with immunosuppressive agents (IST), leading to transfusion independence , or complete recovery of peripheral blood counts, in a ...

    Research Article last updated 02/03/2017 - 9:51am.

  8. Treatment of low-risk myelodysplastic syndromes

    ... of IPSS-R, endogenous erythropoietin levels, and transfusion independence . Doses and duration of therapy of erythropoietic-stimulating ...

    Research Article last updated 01/26/2017 - 10:42am.

  9. Design and rationale of the QUAZAR Lower-Risk MDS (AZA-MDS-003) trial: a randomized phase 3 study of CC-486 (oral azacitidine) plus best supportive care vs placebo plus best supportive care in patients with IPSS lower-risk myelodysplastic syndromes and po

    ... hematologic improvement in 28 % of patients and RBC transfusion independence sustained for 56 days in 47 % of patients with baseline ...

    Research Article last updated 06/23/2016 - 10:17am.

  10. Efficacy and Safety of Lenalidomide for Treatment of Low-/Intermediate-1-Risk Myelodysplastic Syndromes with or without 5q Deletion: A Systematic Review and Meta-Analysis

    ... could effectively induce red blood cell (RBC) transfusion independence (TI) in patients with lower-risk (Low/Intermediate-1) ...

    Research Article last updated 11/28/2016 - 9:36am.