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  1. Robert A. Brodsky, MD

    ... antibody eculizimab was developed to combat the thrombosis that constitutes a leading cause of death in PNH, but produces a ...

    Bio last updated 09/12/2016 - 11:04am.

  2. 2015 PNH Research Grant Guidelines

    ... components of PNH Increased understanding of thrombosis within PNH, including mechanisms, detection and diagnosis, and ...

    Page last updated 08/25/2016 - 12:55pm.

  3. Chao-Yie Yang, MD, PhD

    ... in PNH. Patients suffer from hemolysis , thrombosis and bone marrow failure . Current FDA-approved only ...

    Grant Recipient last updated 08/09/2016 - 1:02pm.

  4. David Araten, MD

    ... Secondary mutations and thrombosis in PNH Original Research Center:  ... were had been on preventive medicines and neither had thrombosis . It is predicted that this technique may be useful for ...

    Grant Recipient last updated 11/30/2016 - 10:51am.

  5. PNH 101: Understanding Diagnosis and Treatment

    ... of hemolysis (red blood cells breaking apart) and thrombosis (blood clots) Your treatment options and the advances in PNH ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  6. PNH 101: Understanding Diagnosis and Treatment

    ... of hemolysis (red blood cells breaking apart) and thrombosis (blood clots) Your treatment options and the advances in ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  7. Interviews with the Experts: The Complement System in PNH

    ... of consequences, including hemolytic anemia , thrombosis because of inflammation, and kidney problems because of free ...

    Interview last updated 08/31/2016 - 8:39am.

  8. Eculizumab in Paroxysmal Nocturnal Hemoglobinuria (PNH): A Report of All 153 Patients Treated in the UK

    ... with PNH have a very high rate of blood clotting ( thrombosis ) and that eculizumab reduces the chances of this complication by ...

    Research Review last updated 05/02/2016 - 9:24am.

  9. Pegylated Interferon Alfa-2a Salvage Therapy in High Risk Polycythemia Vera (PV) or Essential Thrombocythemia (ET)

    ... Age ≥ 60 years Previous documented thrombosis , erythromelalgia or migraine (severe, recurrent, requiring ... count ≥ 1500 x 10 to 9/L Previous documented thrombosis, erythromelalgia or migraine (severe, recurrent, requiring ... severe migraines requiring medication, abdominal vein thrombosis, deep vein thrombosis) while being treated with maximal tolerated ...

    Clinical Trial last updated 04/29/2016 - 9:59am.

  10. Insights into the Natural History of Paroxysmal Nocturnal Hemoglobinuria (PNH): Analysis of the Presenting Clinical, Haematological and Flow Cytometric Features of 705 Patients Leads to Improved Classification and Prediction of Clinical Course

    ... cells in the bone marrow), hemolysis with or without thrombosis (clots in blood vessels), and PNH clone size could be a ...

    Research Review last updated 05/02/2016 - 9:20am.