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  1. How I treat paroxysmal nocturnal hemoglobinuria.

    ... hemolytic anemia , bone marrow failure , and thrombosis . Many of the clinical manifestations of the disease result from ... improving quality of life, and reducing the risk for thrombosis in PNH patients. Insights into the relevance of detecting PNH cells ...

    Research Article last updated 10/11/2011 - 5:58pm.

  2. Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH).

    ... associated with pancytopenia or venous thrombosis . This disorder is a consequence of acquired somatic mutations in ...

    Research Article last updated 10/22/2013 - 3:44pm.

  3. Baseline characteristics and disease burden in patients in the international paroxysmal nocturnal hemoglobinuria registry

    ... hemolytic anemia , bone marrow failure , thrombosis , and, frequently, poor quality of life. The International PNH ...

    Research Article last updated 03/06/2014 - 11:30am.

  4. Long term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival.

    ... to PNH. Twenty-one of the 79 patients (27%) had a thrombosis prior to starting eculizumab (5.6 events per 100 patient years) ... p<0.001). Twenty-one patients with no prior history of thrombosis discontinued warfarin after starting eculizumab with no ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review

    ... Prophylaxis and treatment of arterial and venous thrombosis currently remain a challenge in PNH. ...

    Research Article last updated 04/07/2015 - 12:36pm.

  6. Long-term outcome of fludarabine-based reduced intensity allogeneic hematopoietic cell transplantation for debilitating paroxysmal nocturnal hemoglobinuria

    ... characterized by intravascular hemolysis , venous- thrombosis , and bone marrow failure . Seventeen patients ...

    Research Article last updated 06/02/2014 - 11:39am.

  7. Efficacy and safety of eculizumab in children and adolescents with paroxysmal nocturnal hemoglobinuria

    ... complications of chronic hemolysis , recurrent thrombosis , marrow failure, serious infections, abdominal pain, chronic ...

    Research Article last updated 05/22/2014 - 8:29am.

  8. Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine.

    ... , nor did they experience hemolysis or thrombosis , and they did not require specific interventions with ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. Paroxysmal nocturnal hemoglobinuria from bench to bedside

    ... esophageal spasm , fatigue, and possibly thrombosis . Aerolysin is a pore-forming toxin that binds GPI-anchored ...

    Research Article last updated 10/11/2011 - 5:58pm.

  10. Loss of expression of neutrophil proteinase-3: a contributory factor in thrombotic risk in paroxysmal nocturnal hemoglobinuria.

    ... proteinase 3 levels, clone size and history of thrombosis . In addition, we found that treating platelets ex vivo with ...

    Research Article last updated 10/11/2011 - 5:58pm.