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  1. Paroxysmal nocturnal hemoglobinuria

    ... disorder that manifests with hemolytic anemia , thrombosis and peripheral blood cytopenias. The absence of two ...

    Research Article last updated 10/02/2014 - 8:35am.

  2. Complement Blockade with a C1 Esterase Inhibitor in Paroxysmal Nocturnal Hemoglobinuria

    ... , bone marrow failure and a propensity for thrombosis . These patients experience both intra- and extravascular ...

    Research Article last updated 08/04/2014 - 8:13am.

  3. Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH).

    ... associated with pancytopenia or venous thrombosis . This disorder is a consequence of acquired somatic mutations in ...

    Research Article last updated 10/22/2013 - 3:44pm.

  4. Predictors of Hemoglobin Response to Eculizumab Therapy in Paroxysmal Nocturnal Hemoglobinuria

    ... intravascular hemolysis and reduce the risk of thrombosis . DESIGN AND METHODS: This is a retrospective, ... and lactate dehydrogenase <1.5 upper limit of normal without thrombosis. These patients did not achieve normal hemoglobins for age and sex. ...

    Research Article last updated 11/05/2012 - 10:28am.

  5. Baseline characteristics and disease burden in patients in the international paroxysmal nocturnal hemoglobinuria registry

    ... hemolytic anemia , bone marrow failure , thrombosis , and, frequently, poor quality of life. The International PNH ...

    Research Article last updated 03/06/2014 - 11:30am.

  6. Long-term effect of the complement inhibitor eculizumab on kidney function in patients with paroxysmal nocturnal hemoglobinuria.

    ... with chronic hemolysis , anemia , and thrombosis . Renal damage in PNH is associated with chronic hemosiderosis and/or microvascular thrombosis. We determined the incidence of renal dysfunction or damage, ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. How I treat paroxysmal nocturnal hemoglobinuria.

    ... anemia , bone marrow failure , and thrombosis . Many of the clinical manifestations of the disease result from ... improving quality of life, and reducing the risk for thrombosis in PNH patients. Insights into the relevance of detecting PNH cells ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review

    ... Prophylaxis and treatment of arterial and venous thrombosis currently remain a challenge in PNH. ...

    Research Article last updated 04/07/2015 - 12:36pm.

  9. Long term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival.

    ... to PNH. Twenty-one of the 79 patients (27%) had a thrombosis prior to starting eculizumab (5.6 events per 100 patient years) ... p<0.001). Twenty-one patients with no prior history of thrombosis discontinued warfarin after starting eculizumab with no ...

    Research Article last updated 10/11/2011 - 5:58pm.

  10. Long-term outcome of fludarabine-based reduced intensity allogeneic hematopoietic cell transplantation for debilitating paroxysmal nocturnal hemoglobinuria

    ... characterized by intravascular hemolysis , venous- thrombosis , and bone marrow failure . Seventeen patients ...

    Research Article last updated 06/02/2014 - 11:39am.