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  1. Allogeneic hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: a retrospective single-center study

    ... a significant relationship between a positive history of thrombosis and a higher mortality rate. HSCT has curative role in ...

    Research Article last updated 11/02/2016 - 10:41am.

  2. Diagnostic screening of paroxysmal nocturnal hemoglobinuria: Prospective multicentric evaluation of the current medical indications

    ... been submitted for PNH testing because of unexplained thrombosis in the absence of cytopenia , were positive (0.4%). ... screening algorithms are needed for patients presenting with thrombosis and normal blood cell counts. Bone ...

    Research Article last updated 10/06/2016 - 8:56am.

  3. Keith McCrae, MD

    ... with PNH are at increased risk for the development of thrombosis , or blood clots, that may affect arteries or veins and cause ... One mechanism that may contribute to the development of thrombosis in PNH is the formation of microparticles. Microparticles are ...

    Grant Recipient last updated 02/27/2017 - 7:05am.

  4. Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuria

    ... - often including blood transfusion , anti- thrombosis prophylaxis, and sometimes thrombolytic therapy - or allogeneic ...

    Research Article last updated 06/07/2016 - 10:56am.

  5. Paroxysmal nocturnal hemoglobinuria in pediatric patients.

    ... marrow failure , intravascular hemolysis , and thrombosis . To further characterize the clinical presentation and outcome ... excessive blasts or leukemic transformation. Thrombosis occurred in 6 patients. Five patients underwent hematopoietic ...

    Research Article last updated 12/12/2011 - 10:07am.

  6. Evaluation of hemostasis and endothelial function in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab.

    ... (PNH) is associated with an increased risk of thrombosis through unknown mechanisms. DESIGN AND METHODS: We ... the patients, including those with no history of clinical thrombosis. Treatment with eculizumab was associated with significant ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Paroxysmal Nocturnal Hemoglobinuria: A Complement-Mediated Hemolytic Anemia

    ... uncontrolled complement activation, a propensity for thrombosis and marrow failure. The hemolysis is largely mediated by ...

    Research Article last updated 06/23/2015 - 9:32am.

  8. Improving cytopenia with splenic artery embolization in a patient with paroxysmal nocturnal hemoglobinuria on eculizumab

    ... hemolysis , aplasia and an increased risk of thrombosis . We describe a patient under treatment with the anti-complement ... complications of splenectomy, especially that of thrombosis. Bone Marrow Diseases:  ...

    Research Article last updated 01/08/2014 - 9:53am.

  9. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... and morbidities that include anemia , thrombosis , renal impairment, pulmonary hypertension, and bone marrow ... attack contributes to additional complications, such as thrombosis. Eculizumab , a humanized monoclonal antibody against ...

    Research Article last updated 05/14/2013 - 3:28pm.

  10. Self-injected PNH therapy on the horizon

    ... well, which could help in preventing potentially fatal thrombosis among PNH patients. Soliris reduces thrombotic events, but maybe ...

    Article last updated 07/07/2016 - 9:40am.