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  1. Allogeneic hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: a retrospective single-center study

    ... a significant relationship between a positive history of thrombosis and a higher mortality rate. HSCT has curative role in ...

    Research Article last updated 11/02/2016 - 10:41am.

  2. Diagnostic screening of paroxysmal nocturnal hemoglobinuria: Prospective multicentric evaluation of the current medical indications

    ... been submitted for PNH testing because of unexplained thrombosis in the absence of cytopenia , were positive (0.4%). ... screening algorithms are needed for patients presenting with thrombosis and normal blood cell counts. Bone ...

    Research Article last updated 10/06/2016 - 8:56am.

  3. Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuria

    ... - often including blood transfusion , anti- thrombosis prophylaxis, and sometimes thrombolytic therapy - or allogeneic ...

    Research Article last updated 06/07/2016 - 10:56am.

  4. Paroxysmal nocturnal hemoglobinuria in pediatric patients.

    ... marrow failure , intravascular hemolysis , and thrombosis . To further characterize the clinical presentation and outcome ... excessive blasts or leukemic transformation. Thrombosis occurred in 6 patients. Five patients underwent hematopoietic ...

    Research Article last updated 12/12/2011 - 10:07am.

  5. Research and Education Council

    ... of bone marrow failure conditions (e.g., blood clotting/ thrombosis in PNH, iron overload in MDS, etc). Members ...

    Page last updated 06/20/2017 - 9:22am.

  6. Self-injected PNH therapy on the horizon

    ... well, which could help in preventing potentially fatal thrombosis among PNH patients. Soliris reduces thrombotic events, but maybe ...

    Article last updated 07/07/2016 - 9:40am.

  7. Evaluation of hemostasis and endothelial function in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab.

    ... (PNH) is associated with an increased risk of thrombosis through unknown mechanisms. DESIGN AND METHODS: We ... the patients, including those with no history of clinical thrombosis. Treatment with eculizumab was associated with significant ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. Paroxysmal Nocturnal Hemoglobinuria: A Complement-Mediated Hemolytic Anemia

    ... uncontrolled complement activation, a propensity for thrombosis and marrow failure. The hemolysis is largely mediated by ...

    Research Article last updated 06/23/2015 - 9:32am.

  9. Improving cytopenia with splenic artery embolization in a patient with paroxysmal nocturnal hemoglobinuria on eculizumab

    ... hemolysis , aplasia and an increased risk of thrombosis . We describe a patient under treatment with the anti-complement ... complications of splenectomy, especially that of thrombosis. Bone Marrow Diseases:  ...

    Research Article last updated 01/08/2014 - 9:53am.

  10. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... and morbidities that include anemia , thrombosis , renal impairment, pulmonary hypertension, and bone marrow ... attack contributes to additional complications, such as thrombosis. Eculizumab , a humanized monoclonal antibody against ...

    Research Article last updated 05/14/2013 - 3:28pm.