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  1. Efficacy and Safety of Lenalidomide for Treatment of Low-/Intermediate-1-Risk Myelodysplastic Syndromes with or without 5q Deletion: A Systematic Review and Meta-Analysis

    ... , leukopenia, anemia , deep vein thrombosis , diarrhea, fatigue and rash were 51% (95% CI 30-73%), 31% (95% ...

    Research Article last updated 11/28/2016 - 9:36am.

  2. Diagnostic screening of paroxysmal nocturnal hemoglobinuria: Prospective multicentric evaluation of the current medical indications

    ... been submitted for PNH testing because of unexplained thrombosis in the absence of cytopenia , were positive (0.4%). ... screening algorithms are needed for patients presenting with thrombosis and normal blood cell counts. ...

    Research Article last updated 10/06/2016 - 8:56am.

  3. Improving cytopenia with splenic artery embolization in a patient with paroxysmal nocturnal hemoglobinuria on eculizumab

    ... hemolysis , aplasia and an increased risk of thrombosis . We describe a patient under treatment with the anti-complement ... complications of splenectomy, especially that of thrombosis. Bone Marrow ...

    Research Article last updated 01/08/2014 - 9:53am.

  4. Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuria

    ... - often including blood transfusion , anti- thrombosis prophylaxis, and sometimes thrombolytic therapy - or allogeneic ...

    Research Article last updated 06/07/2016 - 10:56am.

  5. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... and morbidities that include anemia , thrombosis , renal impairment, pulmonary hypertension, and bone marrow ... attack contributes to additional complications, such as thrombosis. Eculizumab , a humanized monoclonal antibody against ...

    Research Article last updated 05/14/2013 - 3:28pm.

  6. Paroxysmal Nocturnal Hemoglobinuria: A Complement-Mediated Hemolytic Anemia

    ... uncontrolled complement activation, a propensity for thrombosis and marrow failure. The hemolysis is largely mediated by ...

    Research Article last updated 06/23/2015 - 9:32am.

  7. Paroxysmal nocturnal hemoglobinuria

    ... disorder that manifests with hemolytic anemia , thrombosis and peripheral blood cytopenias. The absence of two ...

    Research Article last updated 10/02/2014 - 8:35am.

  8. Complement Blockade with a C1 Esterase Inhibitor in Paroxysmal Nocturnal Hemoglobinuria

    ... , bone marrow failure and a propensity for thrombosis . These patients experience both intra- and extravascular ...

    Research Article last updated 08/04/2014 - 8:13am.

  9. Predictors of Hemoglobin Response to Eculizumab Therapy in Paroxysmal Nocturnal Hemoglobinuria

    ... intravascular hemolysis and reduce the risk of thrombosis . DESIGN AND METHODS: This is a retrospective, ... and lactate dehydrogenase <1.5 upper limit of normal without thrombosis. These patients did not achieve normal hemoglobins for age and sex. ...

    Research Article last updated 11/05/2012 - 10:28am.

  10. Long-term effect of the complement inhibitor eculizumab on kidney function in patients with paroxysmal nocturnal hemoglobinuria.

    ... with chronic hemolysis , anemia , and thrombosis . Renal damage in PNH is associated with chronic hemosiderosis and/or microvascular thrombosis. We determined the incidence of renal dysfunction or damage, ...

    Research Article last updated 10/11/2011 - 5:58pm.