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  1. Keith McCrae, MD

    ... with PNH are at increased risk for the development of thrombosis , or blood clots, that may affect arteries or veins and cause ... One mechanism that may contribute to the development of thrombosis in PNH is the formation of microparticles. Microparticles are ...

    Grant Recipient last updated 02/27/2017 - 7:05am.

  2. Zonal cutaneous ulceration and necrosis of the lower abdomen due to cutaneous thrombosis associated with paroxysmal nocturnal hemoglobinuria

    Journal Title:  J Dermatol Primary Author:  Yamada T Author(s):  Yamada T, Ku...

    Research Article last updated 11/02/2016 - 10:35am.

  3. Paroxysmal Nocturnal Hemoglobinuria: From Bench to Bed

    ... a variety of clinical manifestations, such as anemia, thrombosis , kidney disease, smooth muscle dystonias, abdominal pain, ...

    Research Article last updated 11/28/2016 - 11:40am.

  4. Efficacy and Safety of Lenalidomide for Treatment of Low-/Intermediate-1-Risk Myelodysplastic Syndromes with or without 5q Deletion: A Systematic Review and Meta-Analysis

    ... , leukopenia, anemia , deep vein thrombosis , diarrhea, fatigue and rash were 51% (95% CI 30-73%), 31% (95% ...

    Research Article last updated 11/28/2016 - 9:36am.

  5. The dysfunction of platelets in paroxysmal nocturnal hemoglobinuria

    ... INTRODUCTION: Thrombosis is a dangerous complication of paroxysmal nocturnal ... rate. However, the mechanism underlying the development of thrombosis in PNH remains unclear. To explore this, platelet function ...

    Research Article last updated 11/02/2016 - 10:37am.

  6. Positive Impact of Eculizumab Therapy on Surgery for Budd-Chiari Syndrome in a Patient with Paroxysmal Nocturnal Hemoglobinuria and a Long-Term History of Thrombosis

    ... with severe end-organ damage and a high risk of thrombosis . Budd-Chiari syndrome , which develops after thrombotic ...

    Research Article last updated 11/02/2016 - 2:49pm.

  7. Pathogenesis of paroxysmal nocturnal hemoglobinuria

    ... from complement attack. Hemolytic anemia , venous thrombosis , and bone marrow failure are thus the resulting triad of ...

    Research Article last updated 11/02/2016 - 2:52pm.

  8. Allogeneic hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: a retrospective single-center study

    ... a significant relationship between a positive history of thrombosis and a higher mortality rate. HSCT has curative role in ...

    Research Article last updated 11/02/2016 - 10:41am.

  9. Diagnostic screening of paroxysmal nocturnal hemoglobinuria: Prospective multicentric evaluation of the current medical indications

    ... been submitted for PNH testing because of unexplained thrombosis in the absence of cytopenia , were positive (0.4%). ... screening algorithms are needed for patients presenting with thrombosis and normal blood cell counts. ...

    Research Article last updated 10/06/2016 - 8:56am.

  10. David Araten, MD

    ... Secondary mutations and thrombosis in PNH Original Research ... were had been on preventive medicines and neither had thrombosis . It is predicted that this technique may be useful for ...

    Grant Recipient last updated 11/30/2016 - 10:51am.