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  1. Even "Moderate" Dose Cyclophosphamide for Severe Aplastic Anemia Is Associated with Significant Toxicities and Does Not Prevent Relapse and Clonal Evolution

    ... of bone marrow failure syndromes associated with telomere abnormalities and the role of telomere abnormalities in aplastic anemia . Abstract #1259 ...

    Research Review last updated 05/02/2016 - 9:23am.

  2. Radiation- and Alkylator-free Bone Marrow Transplantation Regimen for Patients With Dyskeratosis Congenita

    ... and oral leukoplakia. DC is part of a spectrum of telomere biology disorders, which include some forms of inherited ...

    Clinical Trial last updated 04/27/2016 - 8:49am.

  3. Clonal Evolution in Aplastic Anemia is Driven by Chromosomal Instability Rather than Mutations in Myeloid Malignancy Candidate Gene

    ... (changes) in genes and unstable chromosomes (measured by telomere length) in 43 patients with aplastic anemia. Aplastic anemia had ... the activity of telomerase, an enzyme that maintains telomere length, might reduce the risk of cancer in patients with aplastic ...

    Research Review last updated 05/02/2016 - 9:20am.

  4. Causes

    ... be of help: Dyskeratosis Congenita Outreach : a Telomere Biology Disorder The Diamond Blackfan Anemia Foundation, ...

    Topic section last updated 06/30/2016 - 9:46am.

  5. Pathogenesis of MDS: An overview of molecular and non-molecular aspects of the disease

    ... the bone marrow microenvironment, apoptosis, cytokines, telomere length, and immune factors.  Conclusions: MDS is a ...

    Research Review last updated 05/02/2016 - 9:14am.

  6. Scientific Symposium Co-Chair Richard Stone, MD Discusses Progress and New Directions in Bone Marrow Failure Disease Research

    ... by mutation in genes encoding for members of the telomere complex. A ribosomopathy can also produce bone marrow failure, ... aplastic anemia, whether on an autoimmune basis or due to a telomere problem, we can use different therapies for those different categories ...

    Interview last updated 04/29/2014 - 12:01pm.

  7. Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

    ... with bone marrow failure syndromes (BMFS) - telomere length, TERC and TERT mutations was done on protocol ... genes associated with bone marrow failure syndromes (BMFS) - telomere length, TERC and TERT mutations was done on protocol 04-H-0012 at the ...

    Clinical Trial last updated 04/28/2016 - 2:40pm.

  8. From Bench to Bedside: Why Research is Important

    ... highlights found on our website include: Telomere gene mutation may be found in patients who seem to have a primary ...

    Page last updated 03/19/2016 - 12:22pm.

  9. Luis Batista, PhD

    ... derived from bone marrow failure patients that have telomere attrition as a platform for the development of clinical therapies ... the human lifetime. When a cell reaches a critical telomere length, after several rounds of division, it becomes unable to ...

    Grant Recipient last updated 06/09/2015 - 9:22am.

  10. Aplastic Anemia Connection - Research Update

    ... DeZern, who summarized research on the prognostic value of telomere attrition in patients with aplastic anemia.  Read the summary ...

    Page last updated 02/14/2014 - 1:05pm.