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  1. Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): An initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC)

    ... response. Areas of controversy included the need for telomere length results prior to IST, the time after IST initiation ...

    Research Article last updated 12/17/2013 - 8:30am.

  2. Eltrombopag Added to IST Yields Encouraging Results

    ... When we explored the data further, we also noticed that telomere length – they are the bits at the end of the chromosomes ... familial causes of bone marrow failure , such as telomere diseases or dyskeratosis congenita , and the impact of ...

    Interview last updated 05/24/2017 - 7:44am.

  3. Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy.

    ... subjected to DNA repair activities that would result in telomere fusion, degradation, or recombination. Both the DNA and protein components of the telomere are required for this essential function, because insufficient ...

    Research Article last updated 08/07/2013 - 9:19am.

  4. Dr. Kasiani Myers: Acquired and Inheirited Bone Marrow Failure

    ... translate the protein in our bodies) and others involve telomere diseases (the ends of our chromosomes that protect our ...

    Interview last updated 02/14/2017 - 8:34am.

  5. Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia.

    ... In cell and animal models, telomere erosion promotes chromosomal instability via ... epidemiological and indirect. Here we directly implicate telomere shortening as a critical molecular event for malignant evolution in ...

    Research Article last updated 10/31/2011 - 2:58pm.

  6. Very Short Telomeres of Peripheral Blood Leukocytes Precede Clinical Progression to Myelodysplasia with Monosomy 7 in Aplastic Anemia Patients

    ... of bone marrow failure syndromes associated with telomere abnormalities and the role of telomere abnormalities in aplastic anemia . Abstract Number #1265 ...

    Research Review last updated 05/02/2016 - 9:24am.

  7. Aplastic Anemia & MDS International Foundation: Bone marrow failure disease scientific symposium 2012

    ... cancer development. The clinical relevance of varying telomere lengths (TL) and/or mutations in genes of the telomerase complex ... in telomerase genes. The possibility of modulating telomere attrition rate with sex hormones could positively affect clonal ...

    Research Article last updated 01/23/2015 - 3:36pm.

  8. Telomerase, hTERT and splice variants in patients with myelodysplastic syndromes

    ... in MDS and its relation to telomerase activity, telomere length and hTERT expression. The telomere length in PBMCs of patients with MDS cases was significantly shorter ...

    Research Article last updated 06/02/2014 - 10:45am.

  9. Aplastic anemia: pathophysiology and treatment.

    ... the pathogenesis of AA have identified defective telomere maintenance as an important explanation for the onset of marrow ...

    Research Article last updated 10/11/2011 - 5:58pm.

  10. AAMDSIF Scientific Symposium 2016 Presentations

    ... in the Genomic Era 496.99 KB Telomere Modulation in Vivo 3.51 MB Immunodeficiency ...

    Page last updated 08/17/2016 - 3:32pm.