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  1. Impaired proliferative potential of bone marrow mesenchymal stem cells in patients with myelodysplastic syndromes is associated with abnormal WNT signaling pathway

    ... CDKN2A, CDKN2B, along with PARG1, whereas the mean telomere length was up-regulated in patient MSCs. MDS-derived MSCs ...

    Research Article last updated 04/09/2014 - 9:36am.

  2. Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): An initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC)

    ... response. Areas of controversy included the need for telomere length results prior to IST, the time after IST initiation ...

    Research Article last updated 12/17/2013 - 8:30am.

  3. Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy.

    ... subjected to DNA repair activities that would result in telomere fusion, degradation, or recombination. Both the DNA and protein components of the telomere are required for this essential function, because insufficient ...

    Research Article last updated 08/07/2013 - 9:19am.

  4. Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia.

    ... In cell and animal models, telomere erosion promotes chromosomal instability via ... epidemiological and indirect. Here we directly implicate telomere shortening as a critical molecular event for malignant evolution in ...

    Research Article last updated 10/31/2011 - 2:58pm.

  5. Coleman Lindsley, MD, PhD

    ... Impact of telomere length and telomerase gene mutations on allogeneic stem cell ... dyskeratosis congenita , which causes a defect in telomere maintenance and have an increased risk of developing MDS and ...

    Grant Recipient last updated 06/05/2017 - 11:04am.

  6. Aplastic Anemia & MDS International Foundation: Bone marrow failure disease scientific symposium 2012

    ... cancer development. The clinical relevance of varying telomere lengths (TL) and/or mutations in genes of the telomerase complex ... in telomerase genes. The possibility of modulating telomere attrition rate with sex hormones could positively affect clonal ...

    Research Article last updated 01/23/2015 - 3:36pm.

  7. Telomerase, hTERT and splice variants in patients with myelodysplastic syndromes

    ... in MDS and its relation to telomerase activity, telomere length and hTERT expression. The telomere length in PBMCs of patients with MDS cases was significantly shorter ...

    Research Article last updated 06/02/2014 - 10:45am.

  8. Very Short Telomeres of Peripheral Blood Leukocytes Precede Clinical Progression to Myelodysplasia with Monosomy 7 in Aplastic Anemia Patients

    ... of bone marrow failure syndromes associated with telomere abnormalities and the role of telomere abnormalities in aplastic anemia . Abstract Number #1265 ...

    Research Review last updated 05/02/2016 - 9:24am.

  9. Aplastic anemia: pathophysiology and treatment.

    ... the pathogenesis of AA have identified defective telomere maintenance as an important explanation for the onset of marrow ...

    Research Article last updated 10/11/2011 - 5:58pm.

  10. Eltrombopag Added to IST Yields Encouraging Results

    ... When we explored the data further, we also noticed that telomere length – they are the bits at the end of the chromosomes ...

    Interview last updated 05/24/2017 - 7:44am.