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  1. Prognostic value of telomere attrition in patients with aplastic anemia

    ... Abstract:  Prognostic value of telomere attrition in patients with aplastic anemia. ... (PNH) clone and reticulocyte count. Telomere length measurements are another example of a potentially useful ...

    Research Review last updated 05/02/2016 - 9:25am.

  2. Telomere length in myelodysplastic syndromes

    ... The relationship between telomere length (TL) and predisposition to myelodysplastic syndromes ... studies are needed to further investigate constitutional telomere attrition as a possible predisposing factor for MDS. ...

    Research Article last updated 10/11/2011 - 5:58pm.

  3. Telomere length in hematopoietic stem cell transplantation for severe aplastic anemia: is it ready for "prime time"?

    ...

    Research Article last updated 04/06/2015 - 8:56am.

  4. Updates on the pathophysiology and treatment of aplastic anemia: a comprehensive review.

    ... mechanisms, and the genesis of more novel concepts of telomere attrition. Many of these concepts are steadily finding their way ... by karyotypic abnormalities, genomic instability, telomere attrition, and recurrent somatic mutations reminiscent of myeloid ...

    Research Article last updated 05/02/2017 - 10:13am.

  5. MDS patients in promising AML study on telomeres

    ... levels of treatment. "The next step is to assess telomere length in larger studies to establish how it can be integrated ...

    Article last updated 05/10/2017 - 9:45am.

  6. Biomarkers for predicting clinical response to immunosuppressive therapy in aplastic anemia

    ... paroxysmal nocturnal hemoglobinuria (PNH), and telomere length (TL). While previous studies have provided substantial ...

    Research Article last updated 06/22/2016 - 10:19am.

  7. Coleman Lindsley, MD, PhD

    ... Impact of telomere length and telomerase gene mutations on allogeneic stem cell ... dyskeratosis congenita , which causes a defect in telomere maintenance and have an increased risk of developing MDS and ...

    Grant Recipient last updated 06/05/2017 - 11:04am.

  8. Somatic mutations identify a sub-group of aplastic anemia patients that progress to myelodysplastic syndrome

    ... DNA. We excluded Fanconi anemia , mutations of telomere maintenance, and a family history of bone marrow failure ... disease duration (37 vs. 8 months, p<0.04), and shorter telomere lengths (median T/S length, 0.9 vs. 1.1, p<0.001), compared to ...

    Research Article last updated 09/04/2014 - 11:05am.

  9. Impaired proliferative potential of bone marrow mesenchymal stem cells in patients with myelodysplastic syndromes is associated with abnormal WNT signaling pathway

    ... CDKN2A, CDKN2B, along with PARG1, whereas the mean telomere length was up-regulated in patient MSCs. MDS-derived MSCs ...

    Research Article last updated 04/09/2014 - 9:36am.

  10. Danielle Townsley, MD, MSc

    ... familial causes of bone marrow failure , such as telomere diseases or dyskeratosis congenita , and the impact of ... the sex hormone , danazol for patients with telomere disorders. ...

    Bio last updated 05/24/2017 - 8:30am.