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  1. Prognostic value of telomere attrition in patients with aplastic anemia

    ... Abstract:  Prognostic value of telomere attrition in patients with aplastic anemia. ... (PNH) clone and reticulocyte count. Telomere length measurements are another example of a potentially useful ...

    Research Review last updated 05/02/2016 - 9:25am.

  2. Telomere length in hematopoietic stem cell transplantation for severe aplastic anemia: is it ready for "prime time"?

    Journal Title:  JAMA Primary Author:  Saad A Author(s):  Saad A, Mineishi S, ...

    Research Article last updated 04/06/2015 - 8:56am.

  3. Foundation Update - September 2017

    ... Webinars? > What are Telomeres? Exploring Telomere Length in Aplastic Anemia ; September 20, 2017, 1:00 PM EDT ...

    Article last updated 09/12/2017 - 7:14am.

  4. Updates on the pathophysiology and treatment of aplastic anemia: a comprehensive review.

    ... mechanisms, and the genesis of more novel concepts of telomere attrition. Many of these concepts are steadily finding their way ... by karyotypic abnormalities, genomic instability, telomere attrition, and recurrent somatic mutations reminiscent of myeloid ...

    Research Article last updated 05/02/2017 - 10:13am.

  5. MDS patients in promising AML study on telomeres

    ... levels of treatment. "The next step is to assess telomere length in larger studies to establish how it can be integrated ...

    Article last updated 05/10/2017 - 9:45am.

  6. Biomarkers for predicting clinical response to immunosuppressive therapy in aplastic anemia

    ... paroxysmal nocturnal hemoglobinuria (PNH), and telomere length (TL). While previous studies have provided substantial ...

    Research Article last updated 06/22/2016 - 10:19am.

  7. Somatic mutations identify a sub-group of aplastic anemia patients that progress to myelodysplastic syndrome

    ... DNA. We excluded Fanconi anemia , mutations of telomere maintenance, and a family history of bone marrow failure ... disease duration (37 vs. 8 months, p<0.04), and shorter telomere lengths (median T/S length, 0.9 vs. 1.1, p<0.001), compared to ...

    Research Article last updated 09/04/2014 - 11:05am.

  8. Impaired proliferative potential of bone marrow mesenchymal stem cells in patients with myelodysplastic syndromes is associated with abnormal WNT signaling pathway

    ... CDKN2A, CDKN2B, along with PARG1, whereas the mean telomere length was up-regulated in patient MSCs. MDS-derived MSCs ...

    Research Article last updated 04/09/2014 - 9:36am.

  9. Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): An initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC)

    ... response. Areas of controversy included the need for telomere length results prior to IST, the time after IST initiation ...

    Research Article last updated 12/17/2013 - 8:30am.

  10. Coleman Lindsley, MD, PhD

    ... Impact of telomere length and telomerase gene mutations on allogeneic stem cell ... dyskeratosis congenita , which causes a defect in telomere maintenance and have an increased risk of developing MDS and ...

    Grant Recipient last updated 06/05/2017 - 11:04am.