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  1. Low Dose Danazol for the Treatment of Telomere Related Diseases

    ... danazol can be used to treat people with short telomere disease who also have bone marrow failure , liver, or lung ... danazol, at high doses, showed a positive influence on telomere length. Additional research is needed to learn more about the role of ...

    Clinical Trial last updated 05/31/2018 - 2:53pm.

  2. Paroxysmal nocturnal hemoglobinuria and telomere length predicts response to immunosuppressive therapy in pediatric aplastic anemia

    ... nocturnal hemoglobinuria populations and a short telomere length were identified as predictive biomarkers of ... The paroxysmal nocturnal hemoglobinuria populations and telomere length were detected by flow cytometry . Forty-seven patients ...

    Research Article last updated 10/12/2015 - 10:20am.

  3. Prognostic value of telomere attrition in patients with aplastic anemia.

    ... cancer development. The clinical relevance of varying telomere lengths (TL) and/or mutations in genes of the telomerase complex ... in telomerase genes. The possibility of modulating telomere attrition rate with sex hormones could positively affect clonal ...

    Research Article last updated 06/20/2013 - 10:25am.

  4. Telomere length in hematopoietic stem cell transplantation for severe aplastic anemia: is it ready for "prime time"?

    Journal Title:  JAMA Primary Author:  Saad A Author(s):  Saad A, Mineishi S, ...

    Research Article last updated 03/03/2015 - 11:53am.

  5. Association between donor leukocyte telomere length and survival after unrelated allogeneic hematopoietic cell transplantation for severe aplastic anemia

    ... recipient and donor pretransplant leukocyte telomere length with outcomes after unrelated donor allogeneic ... EXPOSURES: Recipient and donor pre-HCT leukocyte telomere length classified into long (third tertile) and short (first and ...

    Research Article last updated 03/03/2015 - 11:48am.

  6. Clinical and Genetic Heterogeneity of Telomere Diseases

    ... of bone marrow failure syndromes associated with telomere abnormalities and the role of telomere abnormalities in aplastic anemia . Abstract Number ... failure clinic since 2003. She found that mutations in telomere genes can be found in patients even without family history and should ...

    Research Review last updated 05/02/2016 - 9:24am.

  7. Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia.

    ... in tissue culture and animal models. Variations in telomere length have been reported in severe aplastic anemia but ... OBJECTIVE: To investigate the relationship between telomere length and clinical outcomes in severe aplastic anemia. DESIGN, ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. Telomere Length and Allogeneic Hematopoietic Cell Transplantation for Severe Aplastic Anemia

    ... PubMed Abstract:  Telomere length in hematopoietic stem cell transplantation for severe aplastic ... abbreviated the cell stops proliferating. Consequently, telomere length is a marker of cellular replicative capacity, senescence, ...

    Research Review last updated 05/02/2016 - 9:13am.

  9. Foundation Update - August 2017

    ... Louis, recently published significant research on telomere length in childhood bone marrow failure . He has now been ... Webinars? > What are Telomeres? Exploring Telomere Length in Aplastic Anemia ; September 21, 2017, 1:00 PM ...

    Article last updated 09/05/2017 - 10:53am.

  10. Telomere length in myelodysplastic syndromes

    ... The relationship between telomere length (TL) and predisposition to myelodysplastic syndromes ... studies are needed to further investigate constitutional telomere attrition as a possible predisposing factor for MDS. ...

    Research Article last updated 10/11/2011 - 5:58pm.