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  1. Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

    ... evaluation in non-human primates. A single intraveneous injection of PEG-Cp40 resulted in a prolonged elimination half-life of >5 days ... could be reached with unmodified Cp40 through repetitive subcutaneous administration. In conclusion, peptide inhibitors of C3 ...

    Research Article last updated 03/06/2014 - 11:17am.

  2. A Study of BBI608 in Adult Patients With Advanced, Refractory Hematologic Malignancies

    ... at 1.3 mg/m2/dose as a 3-5 second bolus intravenous (IV) injection or subcutaneous injection twice weekly for 2 weeks (Day 1, 4, 8, and 11) followed ...

    Clinical Trial last updated 04/28/2016 - 3:34pm.

  3. Phase IIA Open Label Study to Evaluate Efficacy and Safety of BL-8040 Followed by (hATG), Cyclosporine and Methyprednisolone in Adult Subjects With Aplastic Anemia or Hypoplastic Myelodysplastic Syndrome

    ... AA or Hypoplastic MDS. Eligible subjects will receive subcutaneous (SC) injections of BL-8040 monotherapy over 10 days. From Day 11 ... for the first 5 days of each month through M6. All BL-8040 injection courses will be given at the site, as either an inpatient or ...

    Clinical Trial last updated 04/26/2016 - 11:45am.

  4. Patrizia Ricci, PhD

    ... of Cp40 in vivo. Indeed, a single intravenous injection of PEG Cp40 resulted in a prolonged elimination half-life of >5 ... could be reached with unmodified Cp40 through repetitive subcutaneous administration. It was important to demonstrate that sustained ...

    Grant Recipient last updated 09/14/2016 - 2:42pm.

  5. Darbepoetin Alfa

    ... erythropoietin levels are low. It is given by injection under the skin (subcutaneous) or in the vein (intravenous). Darbepoetin alfa is approved by the ...

    Drug last updated 03/24/2016 - 12:32pm.

  6. Epoetin Alfa

    ... erythropoietin levels are low. It is given by injection under the skin (subcutaneous) or in the vein (intravenous). Epoetin alfa is approved by the ...

    Drug last updated 03/24/2016 - 12:32pm.

  7. Filgrastim

    ... factor or colony stimulating factorand is given by injection under the skin (subcutaneous) or in the vein (intravenous). Filgrastim is approved by ...

    Drug last updated 03/24/2016 - 12:32pm.

  8. MDS - Treatment (OLD)

    ... Deferoxamine (Desferal®) is usually administered by subcutaneous (under the skin) infusion using a small portable pump about the ... Epogen®):  Epoetin alpha is typically given as an injection (shot) in the arm, abdomen or thigh. Darbepoetin alpha ...

    Topic section last updated 03/10/2016 - 11:01pm.

  9. A Study of Eltrombopag or Placebo in Combination With Azacitidine in Subjects With International Prognostic Scoring System (IPSS) Intermediate-1, Intermediate-2 or High-risk Myelodysplastic Syndromes (MDS)

    ... 300 mg (green) of eltrombopag free acid Drug: Azacitidine Subcutaneous Injection (IV if local standard) Drug: Placebo Eltrombopag matching placebo ...

    Clinical Trial last updated 04/27/2016 - 1:28pm.