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  1. Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes.

    ... and ineffective hematopoiesis . Hematopoietic stem cells (HSCs) and myeloid progenitors in MDS have not been extensively ...

    Research Article last updated 03/05/2013 - 9:20am.

  2. Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... ( PNH ) is a rare blood disease that causes red blood cells to break apart. Doctors call this breaking apart " hemolysis ." It ... inside certain bones. Marrow contains blood-forming stem cells that make copies of themselves to create all 3 types of blood ...

    Page last updated 09/30/2017 - 11:34am.

  3. Hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: long-term results of a retrospective study on behalf of the Gruppo Italiano Trapianto Midollo Osseo (GITMO).

    ... is an acquired clonal disorder of the hemopoietic stem cells for which the only curative treatment is allogeneic hematopoietic ...

    Research Article last updated 10/11/2011 - 5:58pm.

  4. Long-term follow-up after allogeneic stem cell transplantation in patients with severe aplastic anemia after cyclophosphamide plus antithymocyte globulin conditioning

    ... long-term follow-up of patients who underwent hematopoietic stem cell transplantation from an HLA -matched sibling donor after this ... but 2 received bone marrow as the source of stem cells and all but 2 engrafted. Cumulative incidence of acute grade II-IV ...

    Research Article last updated 01/09/2012 - 10:43am.

  5. Mutations of myelodysplastic syndromes (MDS): An update

    ... a heterogeneous pre-malignant disorder of hematopoietic stem cells , through sequencing of several pathway genes has unveiled molecular ...

    Research Article last updated 09/19/2016 - 11:02am.

  6. Transplantation

     

    Page last updated 01/20/2015 - 4:45pm.

  7. The complex pathophysiology of acquired aplastic anemia

    ... Immune mediated destruction of hematopoietic stem/progenitor cells (HSPCs) plays a central role in the pathophysiology of acquired ...

    Research Article last updated 03/03/2015 - 11:32am.

  8. First-line matched related donor hematopoietic stem cell transplantation compared to immunosuppressive therapy in acquired severe aplastic anemia.

    ... immune-mediated functional impairment of hematopoietic stem cells . Transplantation of these cells is a first-line treatment option if ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. A prospective multicenter study of paroxysmal nocturnal hemoglobinuria cells in patients with bone marrow failure.

    ... hemoglobinuria (PNH), a rare clonal hematopoietic stem cell disorder, is characterized by chronic, uncontrolled complement ...

    Research Article last updated 11/21/2013 - 11:54am.

  10. A Prospective Multicenter Study of Paroxysmal Nocturnal Hemoglobinuria Cells in Patients with Bone Marrow Failure.

    ... hemoglobinuria (PNH), a rare clonal hematopoietic stem cell disorder, is characterized by chronic, uncontrolled complement ...

    Research Article last updated 10/22/2013 - 3:42pm.