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  1. Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes.

    ... and ineffective hematopoiesis . Hematopoietic stem cells (HSCs) and myeloid progenitors in MDS have not been extensively ...

    Research Article last updated 03/05/2013 - 9:20am.

  2. Simona Pagliuca, MD

    ... in which the bone marrow and the hematopoietic stem cells that reside there are damaged. This causes a deficiency of all three ...

    Grant Recipient last updated 06/08/2017 - 10:43am.

  3. Long-term follow-up after allogeneic stem cell transplantation in patients with severe aplastic anemia after cyclophosphamide plus antithymocyte globulin conditioning

    ... long-term follow-up of patients who underwent hematopoietic stem cell transplantation from an HLA -matched sibling donor after this ... but 2 received bone marrow as the source of stem cells and all but 2 engrafted. Cumulative incidence of acute grade II-IV ...

    Research Article last updated 01/09/2012 - 10:43am.

  4. Hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: long-term results of a retrospective study on behalf of the Gruppo Italiano Trapianto Midollo Osseo (GITMO).

    ... is an acquired clonal disorder of the hemopoietic stem cells for which the only curative treatment is allogeneic hematopoietic ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. A prospective multicenter study of paroxysmal nocturnal hemoglobinuria cells in patients with bone marrow failure.

    ... hemoglobinuria (PNH), a rare clonal hematopoietic stem cell disorder, is characterized by chronic, uncontrolled complement ...

    Research Article last updated 11/21/2013 - 11:54am.

  6. First-line matched related donor hematopoietic stem cell transplantation compared to immunosuppressive therapy in acquired severe aplastic anemia.

    ... immune-mediated functional impairment of hematopoietic stem cells . Transplantation of these cells is a first-line treatment option if ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. A Prospective Multicenter Study of Paroxysmal Nocturnal Hemoglobinuria Cells in Patients with Bone Marrow Failure.

    ... hemoglobinuria (PNH), a rare clonal hematopoietic stem cell disorder, is characterized by chronic, uncontrolled complement ...

    Research Article last updated 10/22/2013 - 3:42pm.

  8. Deregulated microRNA expression and its pathogenetic implications for myelodysplastic syndromes

    ... (MDS) include a heterogeneous group of clonal hematological stem cell disorders characterized by ineffective hematopoiesis , ... of the differentiation of hematopoietic stem/progenitor cells. Thus, it is not surprising that dysregulation of miRNAs can lead to ...

    Research Article last updated 08/15/2016 - 11:30am.

  9. Advances in the molecular pathology of MDS

    ... other than replacement of the bone marrow with stem cells from a healthy matched donor, is unlikely to achieve cure as patients ...

    Research Review last updated 05/02/2016 - 9:44am.

  10. Novel strategies to prevent relapse after allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia and myelodysplastic syndromes

    ... of haematological neoplasms after allogeneic haematopoietic stem cell transplantation (HSCT) remains one of the leading causes of death. ... interventions to impair growth of residual clonal cells and post-HSCT immune-mediated interventions to enhance the ...

    Research Article last updated 03/02/2015 - 1:25pm.