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  1. Excellent Outcome of Haploidentical Hematopoietic Stem Cell Transplantation in Children and Adolescents with Acquired Severe Aplastic Anemia

    ... anemia (SAA) who received haploidentical hematopoietic stem cell transplantation (HHCT) with in vitro T cell -depleted peripheral blood stem cells . Twelve patients with acquired SAA received a total of 15 HHCTs with ...

    Research Article last updated 03/05/2013 - 8:11am.

  2. Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuria

    ... results from expansion of a clone of hematopoietic cells that, as a consequence of an inactivating mutation of the ... from T-cell-mediated auto-immune damage to hematopoietic stem cells , with the GPI molecule as target. Indeed, GPI-specific CD8+ T ...

    Research Article last updated 06/07/2016 - 10:56am.

  3. Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes.

    ... and ineffective hematopoiesis . Hematopoietic stem cells (HSCs) and myeloid progenitors in MDS have not been extensively ...

    Research Article last updated 03/05/2013 - 9:20am.

  4. Transplantation

     

    Page last updated 01/20/2015 - 4:45pm.

  5. The complex pathophysiology of acquired aplastic anemia

    ... Immune mediated destruction of hematopoietic stem/progenitor cells (HSPCs) plays a central role in the pathophysiology of acquired ...

    Research Article last updated 03/03/2015 - 11:32am.

  6. Long-term follow-up after allogeneic stem cell transplantation in patients with severe aplastic anemia after cyclophosphamide plus antithymocyte globulin conditioning

    ... long-term follow-up of patients who underwent hematopoietic stem cell transplantation from an HLA -matched sibling donor after this ... but 2 received bone marrow as the source of stem cells and all but 2 engrafted. Cumulative incidence of acute grade II-IV ...

    Research Article last updated 01/09/2012 - 10:43am.

  7. Hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: long-term results of a retrospective study on behalf of the Gruppo Italiano Trapianto Midollo Osseo (GITMO).

    ... is an acquired clonal disorder of the hemopoietic stem cells for which the only curative treatment is allogeneic hematopoietic ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. First-line matched related donor hematopoietic stem cell transplantation compared to immunosuppressive therapy in acquired severe aplastic anemia.

    ... immune-mediated functional impairment of hematopoietic stem cells . Transplantation of these cells is a first-line treatment option if ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. A prospective multicenter study of paroxysmal nocturnal hemoglobinuria cells in patients with bone marrow failure.

    ... hemoglobinuria (PNH), a rare clonal hematopoietic stem cell disorder, is characterized by chronic, uncontrolled complement ...

    Research Article last updated 11/21/2013 - 11:54am.

  10. A Prospective Multicenter Study of Paroxysmal Nocturnal Hemoglobinuria Cells in Patients with Bone Marrow Failure.

    ... hemoglobinuria (PNH), a rare clonal hematopoietic stem cell disorder, is characterized by chronic, uncontrolled complement ...

    Research Article last updated 10/22/2013 - 3:42pm.