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  1. Effect of lenalidomide treatment on clonal architecture of myelodysplastic syndromes without 5q deletion

    ... clonal architecture of single CD34+CD38- hematopoietic stem cells was also determined in 5 cases. Four genes had a mutation ...

    Research Article last updated 04/29/2016 - 11:33am.

  2. AAMDSIF Summer Fellowship Grant Program

    ... by profound decrease of the number of red blood cells, white blood cells, and platelets in the blood stream, leading to ... can improve inflammation in bone marrow (BM) allowing stem cells to survive. In this study, we seek to investigate the genetic ...

    Page last updated 05/17/2017 - 1:29pm.

  3. Pathogenesis of myelodysplastic syndromes: an overview of molecular and non-molecular aspects of the disease

    ... a group of clonal disorders arising from hematopoietic stem cells generally characterized by inefficient hematopoiesis , ...

    Research Article last updated 01/20/2015 - 12:52pm.

  4. Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria

    ... (PNH) is a nonmalignant clonal disease of hematopoietic stem cells that is associated with hemolysis , marrow failure, and ...

    Research Article last updated 10/02/2014 - 8:24am.

  5. Allogeneic stem cell transplantation in myelodysplastic syndromes: does pretransplant clonal burden matter?

    ... syndromes (MDS) is allogeneic hematopoietic stem cell transplantation (alloSCT). As alloSCT confers both a short-term ... treatment. Randomized data are lacking. Most hematopoietic cells in patients with MDS are clonal, even in cases without increased marrow ...

    Research Article last updated 04/29/2016 - 10:22am.

  6. Comparison between Matched Related and Alternative Donors of Allogeneic Hematopoietic Stem Cells Transplanted into Adult Patients with Acquired Aplastic Anemia: Multivariate and Propensity Score-Matched Analysis.

    ... anemia (AA) who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) from matched related donors (MRDs), and ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. How do PIG-A mutant paroxysmal nocturnal hemoglobinuria stem cells achieve clonal dominance?

    ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. Cerebral venous thrombosis in paroxysmal nocturnal hemoglobinuria: a series of 15 cases and review of the literature

    ... (PNH) is a rare acquired disorder of hematopoietic stem cells characterized by hemolytic anemia , marrow failure, and a ...

    Research Article last updated 03/02/2015 - 11:38am.

  9. Sergei Vatolin, PhD

    ... Pharmacological restoration of hematopoietic stem cell compartment in aplastic anemia and paroxysmal nocturnal ... very limited. The idea of improvement the quality of blood cells with small molecules may give a new opportunity to cure AA and hope to ...

    Grant Recipient last updated 06/08/2017 - 10:40am.

  10. Deregulated microRNA expression and its pathogenetic implications for myelodysplastic syndromes

    ... (MDS) include a heterogeneous group of clonal hematological stem cell disorders characterized by ineffective hematopoiesis , ... of the differentiation of hematopoietic stem/progenitor cells. Thus, it is not surprising that dysregulation of miRNAs can lead to ...

    Research Article last updated 08/15/2016 - 11:30am.