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  1. Chronic Myelomonocytic Leukemia (CMML)

    ... control, filling the bone marrow and preventing other blood cells from growing. CMML is rare, occurring in about 4 of every 1 million ... rays or particles to destroy cancer cells Stem cell transplant , which replaces blood-forming stem cells in ...

    Topic section last updated 12/16/2016 - 9:42am.

  2. Youmna Kfoury, PhD

    ... Phenotypic and molecular characterization of osteolineage cells in patients with myelodysplastic syndrome ... platform of mesenchymal stromal layers and hematopoietic stem and progenitor cells (HSPCs) using a CRISPR-Cas9 based strategy to knock ...

    Grant Recipient last updated 12/15/2016 - 12:56pm.

  3. REVERSE 1 INCB 18424-271

    ...  Have undergone first allogeneic hematopoietic stem cell transplantation (allo-HSCT) from any donor source using bone marrow , peripheral blood stem cells , or cord blood for hematologic malignancies. Recipients of ...

    Clinical Trial last updated 12/14/2016 - 11:24am.

  4. AA&MDSIF announces PNH grant awards

    ... the functional effects of the PIG-A mutation in CD34+ cells and T- cells shared by PNH, MDS and aplastic anemia patients. The goal is ... immune response in T cells that attack the hematopoietic stem cells . A better understanding of the novel pathways in PNH ...

    Article last updated 12/14/2016 - 11:41am.

  5. Hematopoietic Stem Cell Transplantation in Aplastic Anemia

    ... How do you currently think about the role of stem cell transplantation in aplastic anemia ? This is an exciting ... have to also deal with the risk of relapse of the malignant cells. Relapsed MDS or AML is much more challenging to cure. It all just ...

    Interview last updated 11/28/2016 - 2:58pm.

  6. David Araten, MD

    ... understood in PNH includes the  expansion of an abnormal stem cell clone in the bone marrow (called clonal expansion) which can ... provide a very large percentage of the patient's blood cells. This clone has as its feature the presence of a mutation in a ...

    Grant Recipient last updated 11/30/2016 - 10:51am.

  7. Recent developments in bone marrow transplants

    ... Celgene) maintenance following autologous hematopoietic stem cell transplantation improved survival outcomes without increasing the ... donor . Repeated infusions of mesenchymal stromal cells reduced the incidence of chronic GVHD in patients who underwent ...

    Article last updated 11/16/2016 - 2:56pm.

  8. Allogeneic hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: a retrospective single-center study

    ... (PNH) is a rare clonal disease of hematopoietic stem cell characterized by complement mediated intravascular hemolysis . ... plus cyclophosphamide ), and the source of stem cells was peripheral blood of the donors. Mean age at transplant was ...

    Research Article last updated 11/02/2016 - 10:41am.

  9. Pathogenesis of paroxysmal nocturnal hemoglobinuria

    ... of the PIGA gene in one or several hematopoietic stem cells . Recently, PNH caused by somatic mutation of one allele of the PIGT ...

    Research Article last updated 11/02/2016 - 2:52pm.

  10. AAMDSIF 2016 Grant Recipients, Part One

    ... between excessive inflammation and the destruction of stem cells that are required to maintain daily production of all blood cells. ...

    Article last updated 10/27/2016 - 12:44pm.