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  1. Kate MacNamara, PhD

    ... inflammation ultimately causes destruction of the stem cells required to maintain daily production of all blood cells. ... are known to contribute to pathology, yet exactly how stem cell function is compromised by these factors is not clear and remains an ...

    Grant Recipient last updated 06/08/2017 - 10:43am.

  2. Stem cell origin of myelodysplastic syndromes

    ... the involvement of multipotent, immature hematopoietic cells in the pathophysiology of this disease. Recent studies using ... that the most immature, self-renewing hematopoietic stem cells (HSC), as well as lineage-committed progenitor cells, are ...

    Research Article last updated 01/08/2014 - 9:05am.

  3. Cytogenetics in benzene-associated myelodysplastic syndromes and acute myeloid leukemia: new insights into a disease continuum

    ... complex interactions between primitive hematopoietic stem cells (HSCs) and the extrinsic influences of other cells in the bone ...

    Research Article last updated 04/09/2014 - 9:39am.

  4. AAMDSIF partners on new MDS patient resource

    ... are the result of genetic alterations that cause blood stem cells to become abnormal, rendering bone marrow unable to create ...

    Article last updated 06/28/2016 - 12:43pm.

  5. Paroxysmal nocturnal hemoglobinuria and the age of therapeutic complement inhibition

    ... (PNH) is a rare disease of hematopoietic stem cells due to a mutation in the PIG-A gene leading to a ...

    Research Article last updated 11/05/2013 - 12:37pm.

  6. Patient Inspires Workplace Giving

    ... tests, it was decided that I was a good candidate for a stem cell transplant . My sister was tested and found to be a fully matched ... about a year of preparation, I received my new stem cells on June 8, 2011, almost 5 years ago. After an inpatient stay of ...

    Patient Chronicle last updated 06/28/2016 - 8:12am.

  7. Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuria

    ... results from expansion of a clone of hematopoietic cells that, as a consequence of an inactivating mutation of the ... from T-cell-mediated auto-immune damage to hematopoietic stem cells , with the GPI molecule as target. Indeed, GPI-specific CD8+ T ...

    Research Article last updated 06/07/2016 - 10:56am.

  8. Comparison between Matched Related and Alternative Donors of Allogeneic Hematopoietic Stem Cells Transplanted into Adult Patients with Acquired Aplastic Anemia: Multivariate and Propensity Score-Matched Analysis.

    ... anemia (AA) who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) from matched related donors (MRDs), and ...

    Research Article last updated 10/11/2011 - 5:58pm.

  9. Pathogenesis of myelodysplastic syndromes: an overview of molecular and non-molecular aspects of the disease

    ... a group of clonal disorders arising from hematopoietic stem cells generally characterized by inefficient hematopoiesis , ...

    Research Article last updated 01/20/2015 - 12:52pm.

  10. Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria

    ... (PNH) is a nonmalignant clonal disease of hematopoietic stem cells that is associated with hemolysis , marrow failure, and ...

    Research Article last updated 10/02/2014 - 8:24am.