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  1. Eltrombopag Added to IST Yields Encouraging Results

    ... current work demonstrates that stimulating remaining stem cells with a drug that mimics the actions of a natural growth substance for ...

    Interview last updated 05/24/2017 - 7:44am.

  2. A plasma microRNA signature as a biomarker for acquired aplastic anemia

    ... by marrow hypoplasia, a paucity of hematopoietic stem and progenitor cells, and pancytopenia of the peripheral blood, due to immune attack ...

    Research Article last updated 10/06/2016 - 9:39am.

  3. Identification of Gene Expression-Based Prognostic Markers in the Hematopoietic Stem Cells of Patients With Myelodysplastic Syndromes.

    ... we have used gene expression profiling (GEP) data on CD34+ cells from patients with MDS to determine the relationship between gene ... prognosis. PATIENTS AND METHODS: GEP data on CD34+ cells from 125 patients with MDS with a minimum 12-month follow-up since date ...

    Research Article last updated 09/09/2013 - 10:45am.

  4. The mutational landscape of paroxysmal nocturnal hemoglobinuria revealed: new insights into clonal dominance

    ... (PNH) is a disorder of hematopoietic stem cells that has largely been considered a monogenic disorder due to ...

    Research Article last updated 10/02/2014 - 8:29am.

  5. NHLBI profiles a member of the Foundation’s patient community.

    ... tissue inside the bones — from making enough red blood cells, which carry oxygen to the different parts of the body; white blood ... therapy. The hope: that the treatment would allow the stem cells in her bone marrow to grow and produce normal blood cell levels. ...

    Article last updated 06/13/2016 - 1:51pm.

  6. Reduced ribosomal RNA expression and increased ribosomal DNA promoter methylation in CD34+ cells of patients with myelodysplastic syndromes

    ... (MDS) are clonal disorders of hematopoietic stem cells characterized by ineffective hematopoiesis . The DNA ... DNA methylation have been documented in bone marrow cells from MDS patients, the methylation signatures of specific gene promoters ...

    Research Article last updated 11/05/2012 - 9:58am.

  7. Stem and progenitor cells in myelodysplastic syndromes show aberrant stage specific expansion and harbor genetic and epigenetic alterations.

    ... Even though hematopoietic stem cell (HSC) dysfunction is presumed in MDS, the exact nature of ... relapse. This study demonstrates that stem and progenitor cells in MDS are characterized by stage specific expansions and contain ...

    Research Article last updated 08/30/2012 - 4:05pm.

  8. Stem cell origin of myelodysplastic syndromes

    ... the involvement of multipotent, immature hematopoietic cells in the pathophysiology of this disease. Recent studies using ... that the most immature, self-renewing hematopoietic stem cells (HSC), as well as lineage-committed progenitor cells, are ...

    Research Article last updated 01/08/2014 - 9:05am.

  9. AAMDSIF Summer Fellowship Grant Program

    ... by profound decrease of the number of red blood cells, white blood cells, and platelets in the blood stream, leading to ... can improve inflammation in bone marrow (BM) allowing stem cells to survive. In this study, we seek to investigate the genetic ...

    Page last updated 05/17/2017 - 1:29pm.

  10. Cytogenetics in benzene-associated myelodysplastic syndromes and acute myeloid leukemia: new insights into a disease continuum

    ... complex interactions between primitive hematopoietic stem cells (HSCs) and the extrinsic influences of other cells in the bone ...

    Research Article last updated 04/09/2014 - 9:39am.