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  1. Mutations of myelodysplastic syndromes (MDS): An update

    ... a heterogeneous pre-malignant disorder of hematopoietic stem cells , through sequencing of several pathway genes has unveiled molecular ...

    Research Article last updated 09/19/2016 - 11:02am.

  2. The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells

    ... harbor clonal glycosylphosphatidylinositol-anchor deficient cells arising from a multipotent hematopoietic stem cell acquiring a PIG-A mutation . Many patients with aplastic ...

    Research Article last updated 06/15/2012 - 1:48pm.

  3. Swabbing leaps into the record books, sort of

    ... have already donated either bone marrow or blood stem cells to save the life of someone with cancer, and to encourage more people ...

    Article last updated 10/04/2016 - 2:38pm.

  4. Aplastic Anemia & MDS International Foundation: Bone Marrow Failure Disease Scientific Symposium 2014

    ... are characterized by a failure of the hematopoietic stem cells to produce adequate blood cells, resulting in either cytopenia ...

    Research Article last updated 01/23/2015 - 3:36pm.

  5. Identification of Gene Expression-Based Prognostic Markers in the Hematopoietic Stem Cells of Patients With Myelodysplastic Syndromes.

    ... we have used gene expression profiling (GEP) data on CD34+ cells from patients with MDS to determine the relationship between gene ... prognosis. PATIENTS AND METHODS: GEP data on CD34+ cells from 125 patients with MDS with a minimum 12-month follow-up since date ...

    Research Article last updated 09/09/2013 - 10:45am.

  6. The mutational landscape of paroxysmal nocturnal hemoglobinuria revealed: new insights into clonal dominance

    ... (PNH) is a disorder of hematopoietic stem cells that has largely been considered a monogenic disorder due to ...

    Research Article last updated 10/02/2014 - 8:29am.

  7. Reduced ribosomal RNA expression and increased ribosomal DNA promoter methylation in CD34+ cells of patients with myelodysplastic syndromes

    ... (MDS) are clonal disorders of hematopoietic stem cells characterized by ineffective hematopoiesis . The DNA ... DNA methylation have been documented in bone marrow cells from MDS patients, the methylation signatures of specific gene promoters ...

    Research Article last updated 11/05/2012 - 9:58am.

  8. Recent developments in bone marrow transplants

    ... Celgene) maintenance following autologous hematopoietic stem cell transplantation improved survival outcomes without increasing the ... donor . Repeated infusions of mesenchymal stromal cells reduced the incidence of chronic GVHD in patients who underwent ...

    Article last updated 11/16/2016 - 2:56pm.

  9. Stem and progenitor cells in myelodysplastic syndromes show aberrant stage specific expansion and harbor genetic and epigenetic alterations.

    ... Even though hematopoietic stem cell (HSC) dysfunction is presumed in MDS, the exact nature of ... relapse. This study demonstrates that stem and progenitor cells in MDS are characterized by stage specific expansions and contain ...

    Research Article last updated 08/30/2012 - 4:05pm.

  10. Pexmetinib: a novel dual inhibitor of Tie-2 and p38 MAPK with efficacy in preclinical models of myelodysplastic syndromes and acute myeloid leukemia

    ... that elevation of angiopoietin-1 in myelodysplastic CD34+ stem-like cells is associated with higher risk disease and reduced overall survival in ...

    Research Article last updated 07/18/2016 - 11:12am.