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  1. Sicheng Wen, MD, PhD

    ... Reversal of aplastic anemia by mensenchymal stem cell-derived extracellular vesicles ... in which the body stops producing enough new blood cells. Marrow transplantation, antithymocyte globulin (ATG) treatment ...

    Grant Recipient last updated 01/05/2018 - 1:09pm.

  2. Aplastic Anemia & MDS International Foundation: Bone Marrow Failure Disease Scientific Symposium 2014

    ... are characterized by a failure of the hematopoietic stem cells to produce adequate blood cells, resulting in either cytopenia ...

    Research Article last updated 01/23/2015 - 3:36pm.

  3. Major news in BMT with half-match donors

    ... Texan is first adult in U.S. to receive updated stem cell transplant for leukemia treatment ... cell transplant that uses genetically engineered blood cells from a family member, announced researchers at UT Southwestern Medical ...

    Article last updated 06/14/2016 - 3:02pm.

  4. Update on the diagnosis and management of paroxysmal nocturnal hemoglobinuria

    ... of glycosyl phosphatidylinositol anchor protein-deficient cells. But PNH is clinically heterogeneous, with some patients having a disease ... nonmalignant clonal disease of the hematopoietic stem cells . Bone marrow failure complicates management of PNH because ...

    Research Article last updated 01/26/2017 - 11:03am.

  5. How I treat acquired aplastic anemia

    ... and mortality. Immune destruction of hemopoietic stem cells , plays an important role in the pathogenesis, as shown by successful ...

    Research Article last updated 02/03/2017 - 9:51am.

  6. Reduced ribosomal RNA expression and increased ribosomal DNA promoter methylation in CD34+ cells of patients with myelodysplastic syndromes

    ... (MDS) are clonal disorders of hematopoietic stem cells characterized by ineffective hematopoiesis . The DNA ... DNA methylation have been documented in bone marrow cells from MDS patients, the methylation signatures of specific gene promoters ...

    Research Article last updated 11/05/2012 - 9:58am.

  7. The mutational landscape of paroxysmal nocturnal hemoglobinuria revealed: new insights into clonal dominance

    ... (PNH) is a disorder of hematopoietic stem cells that has largely been considered a monogenic disorder due to ...

    Research Article last updated 10/02/2014 - 8:29am.

  8. Stem and progenitor cells in myelodysplastic syndromes show aberrant stage specific expansion and harbor genetic and epigenetic alterations.

    ... Even though hematopoietic stem cell (HSC) dysfunction is presumed in MDS, the exact nature of ... relapse. This study demonstrates that stem and progenitor cells in MDS are characterized by stage specific expansions and contain ...

    Research Article last updated 08/30/2012 - 4:05pm.

  9. Stem cell origin of myelodysplastic syndromes

    ... the involvement of multipotent, immature hematopoietic cells in the pathophysiology of this disease. Recent studies using ... that the most immature, self-renewing hematopoietic stem cells (HSC), as well as lineage-committed progenitor cells, are ...

    Research Article last updated 01/08/2014 - 9:05am.

  10. AAMDSIF 2016 Grant Recipients, Part One

    ... between excessive inflammation and the destruction of stem cells that are required to maintain daily production of all blood cells. ...

    Article last updated 10/27/2016 - 12:44pm.