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  1. The Myelodysplastic Syndromes: The Era Of Understanding

    ... are a heterogeneous group of clonal haematological stem cell disorders. Allogeneic stem cells transplantation remains the only curative treatment but only a ...

    Research Article last updated 09/24/2014 - 11:05am.

  2. Recent developments in bone marrow transplants

    ... Celgene) maintenance following autologous hematopoietic stem cell transplantation improved survival outcomes without increasing the ... donor . Repeated infusions of mesenchymal stromal cells reduced the incidence of chronic GVHD in patients who underwent ...

    Article last updated 11/16/2016 - 2:56pm.

  3. Pexmetinib: a novel dual inhibitor of Tie-2 and p38 MAPK with efficacy in preclinical models of myelodysplastic syndromes and acute myeloid leukemia

    ... that elevation of angiopoietin-1 in myelodysplastic CD34+ stem-like cells is associated with higher risk disease and reduced overall survival in ...

    Research Article last updated 07/18/2016 - 11:12am.

  4. Shirley O’Brien’s Remarkable Response in a Clinical Trial

    ... syndrome (MDS), a disease that has no cure except for a stem cell transplant . Because I was in my mid-70s, a bone marrow ... causes my disease. The two pills each day allows the white cells to mature properly into normal cells. The bone marrow is no longer ...

    Patient Chronicle last updated 07/19/2017 - 8:12am.

  5. AAMDSIF partners on new MDS patient resource

    ... are the result of genetic alterations that cause blood stem cells to become abnormal, rendering bone marrow unable to create ...

    Article last updated 06/28/2016 - 12:43pm.

  6. The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells

    ... harbor clonal glycosylphosphatidylinositol-anchor deficient cells arising from a multipotent hematopoietic stem cell acquiring a PIG-A mutation . Many patients with aplastic ...

    Research Article last updated 06/15/2012 - 1:48pm.

  7. Patient Inspires Workplace Giving

    ... tests, it was decided that I was a good candidate for a stem cell transplant . My sister was tested and found to be a fully matched ... about a year of preparation, I received my new stem cells on June 8, 2011, almost 5 years ago. After an inpatient stay of ...

    Patient Chronicle last updated 06/28/2016 - 8:12am.

  8. Eltrombopag Added to IST Yields Encouraging Results

    ... current work demonstrates that stimulating remaining stem cells with a drug that mimics the actions of a natural growth substance for ...

    Interview last updated 05/24/2017 - 7:44am.

  9. Aplastic Anemia & MDS International Foundation: Bone Marrow Failure Disease Scientific Symposium 2014

    ... are characterized by a failure of the hematopoietic stem cells to produce adequate blood cells, resulting in either cytopenia ...

    Research Article last updated 01/23/2015 - 3:36pm.

  10. Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuria

    ... results from expansion of a clone of hematopoietic cells that, as a consequence of an inactivating mutation of the ... from T-cell-mediated auto-immune damage to hematopoietic stem cells , with the GPI molecule as target. Indeed, GPI-specific CD8+ T ...

    Research Article last updated 06/07/2016 - 10:56am.