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  1. Clinical Trials Report for May 2015

    ... engraftment with CD3+ /CD19+ depleted peripheral stem cell grafts from mismatched donors. There are two conditioning regimens ... or transplantation of bone marrow or similar blood cells. This study will also help us learn whether a child's age, genetics, or ...

    Page last updated 04/28/2015 - 11:38am.

  2. MDS and MDS/MPN: Past, Present, and Future 2014 American Society of Hematology (ASH) Satellite Symposium Summary for Patients and Families

    ... form and structure of patient blood or bone marrow cells). When used alone, today’s advanced techniques to study genes ... the question Can We Cure Them? The Role of Hematopoietic Stem Cell Transplantation in MDS/MPN.   Treatments for MDS/MPN are ...

    Page last updated 03/13/2015 - 5:00pm.

  3. Interviews with the Experts MDS Genomics: Providing ‘Street View’ Directions of Disease

    ... of each cell, acts as the software program directing how cells grow, divide, sleep or die. Sometimes DNA gets damaged after exposure to toxins or as a normal consequence of aging. If a blood stem cell suffers DNA damage involving a gene important for blood production, ...

    Interview last updated 09/23/2014 - 9:30am.

  4. Pediatric MDS

    ... fi rst spotted as cytopenias (low blood counts). It’s a stem cell disorder in the bone marrow that results in disturbances  in ... relatively low percentage of blasts (immature blood cells in the bone marrow). There’s really no difference in the definition of ...

    Interview last updated 10/24/2012 - 1:31pm.

  5. Conferences, Webinars and Webcasts

    ...   Caregivers   Clinical Trials   Stem Cell Transplantation   Living Well   Nutrition   ... is a rare and serious blood disease that causes red blood cells to break apart. Doctors call this breaking apart " hemolysis ". It happens because your blood cells are missing a protein that protects them from your body's immune ...

    Page last updated 09/30/2014 - 11:50am.

  6. Interviews with the Experts Managing MDS With Supportive Care and Active Treatment

    ... is a longer acting growth factor for white blood cells. These growth factors can sometimes be considered to be part of a ... MDS, one that is potentially curative, is an allogeneic stem cell transplant , but not all patients are suited for or otherwise ...

    Interview last updated 09/22/2014 - 12:25pm.

  7. Lower-Risk MDS: Diagnosis and Treatment Options

    ... is the percentage of blasts , or immature white blood cells in the bone marrow , categorized as less than 5%, 5 to 10%, and 10 ... be aware of in terms of when to start treatment. If stem cell transplantation is the only potential cure for MDS, why don’t we do ...

    Interview last updated 05/18/2012 - 1:28pm.

  8. ASH 2012 - Reviewing MDS Progress from Research and Clinical Perspectives

    ... systems that involve something called “induced pluripotent stem cells” or iPSCs. These are cells created in the laboratory that can be grown ...

    Interview last updated 02/01/2013 - 4:22pm.

  9. Eltrombopag now an approved therapy for certain patients with severe aplastic anemia

    ... therapy and are not candidates for a hematopoietic stem cell transplant. Eltrombopag, works by helping to increase production of blood cells. According to Cynthia Dunbar, M.D., Head, Molecular ...

    Page last updated 08/27/2014 - 2:19pm.

  10. North American Pediatric Aplastic Anemia Consortium Symposium

    ... that causes the bone marrow to stop making blood cells.  As with all rare diseases, there is a relative lack of research to ... exists, particularly with advances in hematopoietic stem cell transplantation (HSCT). Experts in HSCT, Drs Leslie Lehmann ... 90%. The typical time to transplant is 4-6 weeks. The ideal stem cell source is generally accepted to be bone marrow as peripheral blood ...

    Page last updated 10/31/2013 - 4:06pm.