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  1. Drug reduces acute GVHD in unrelated HSCTs

    ... donor myeloablative conditioning hematopoietic stem cell transplant (HSCT).1 In a phase II single-arm study, the ... pro-inflammatory cytokines, regulated antigen-presenting cells through induction of indoleamine 2,3-dioxygenase, and enhanced ... higher at day 30 in peripheral blood mononuclear cells from vorinostat-treated patients  compared with similarly treated ...

    Article last updated 02/27/2017 - 1:45pm.

  2. Resources to Help

    ... the needs of patients facing a  bone marrow , blood stem cell or umbilical  cord blood transplant . In addition to high-quality ... the exchange of high quality haematopoietic  stem cells  for clinical transplantation worldwide and to promote the interests of ...

    Topic section last updated 09/28/2017 - 11:58am.

  3. Strong results for SAA patients at Johns Hopkins

    ... one's own immune system damages blood-making bone marrow cells, which gradually stop producing red and white blood cells and platelets. ... immune system cells but does not harm the donor's blood stem cells , which create new disease-free blood cells in the patient. ...

    Article last updated 02/07/2017 - 11:05am.

  4. Allogeneic hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: a retrospective single-center study

    ... (PNH) is a rare clonal disease of hematopoietic stem cell characterized by complement mediated intravascular hemolysis . ... plus cyclophosphamide ), and the source of stem cells was peripheral blood of the donors. Mean age at transplant was ...

    Research Article last updated 11/02/2016 - 10:41am.

  5. Impaired proliferative potential of bone marrow mesenchymal stem cells in patients with myelodysplastic syndromes is associated with abnormal WNT signaling pathway

    Journal Title:  Stem Cells Dev Primary Author:  ... It has been shown that bone marrow mesenchymal stem cells (MSCs) from patients with myelodysplastic syndromes ...

    Research Article last updated 04/09/2014 - 9:36am.

  6. Hematopoietic Stem Cell Regulation by Type I and II Interferons in the Pathogenesis of Acquired Aplastic Anemia

    ... fails to support production of all three lineages of blood cells, which are necessary for tissue oxygenation, infection control, and ... of cases but involves exhaustion of hematopoietic stem cells (HSC), which are usually present in the bone marrow in a dormant ...

    Research Article last updated 10/06/2016 - 9:44am.

  7. AAMDSIF 2016 Grant Recipients, Part One

    ... between excessive inflammation and the destruction of stem cells that are required to maintain daily production of all blood cells. ...

    Article last updated 10/27/2016 - 12:44pm.

  8. Pathogenesis of paroxysmal nocturnal hemoglobinuria

    ... of the PIGA gene in one or several hematopoietic stem cells . Recently, PNH caused by somatic mutation of one allele of the PIGT ...

    Research Article last updated 11/02/2016 - 2:52pm.

  9. Clone of Patients

    ...

    Page last updated 03/14/2016 - 6:05pm.

  10. Bone marrow mesenchymal stem cells from aplastic anemia patients preserve functional and immune properties and do not contribute to the pathogenesis of the disease

    ... anemia cases remain idiopathic , and hematopoietic stem cell deficiency and impaired immune responses are hallmark underlying ... marrow failure in aplastic anemia. Mesenchymal stem/stromal cells constitute an essential component of the bone marrow hematopoietic ...

    Research Article last updated 04/23/2014 - 10:09am.