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  1. Update on the diagnosis and management of paroxysmal nocturnal hemoglobinuria

    ... of glycosyl phosphatidylinositol anchor protein-deficient cells. But PNH is clinically heterogeneous, with some patients having a disease ... nonmalignant clonal disease of the hematopoietic stem cells . Bone marrow failure complicates management of PNH because ...

    Research Article last updated 01/26/2017 - 11:03am.

  2. Allogeneic hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: a retrospective single-center study

    ... (PNH) is a rare clonal disease of hematopoietic stem cell characterized by complement mediated intravascular hemolysis . ... plus cyclophosphamide ), and the source of stem cells was peripheral blood of the donors. Mean age at transplant was ...

    Research Article last updated 11/02/2016 - 10:41am.

  3. Transplant saves student who thought she had mono

    ... where your bone marrow essentially stops producing blood cells for your body. At first, I thought, Fine! I’ll just take a few ... transplant, which replaced my unhealthy blood-forming stem cells with the healthy ones from my donor. The first 100 days ...

    Article last updated 03/06/2017 - 2:37pm.

  4. SAA patient finds unrelated donor match in 2 weeks

    ... in which bone marrow does not make enough blood cells. He’s been in and out of hospitals countless times for transfusions ... between 18 and 44, and want to register as a bone marrow/stem cell donor can do it at join.bethematch.org/hope4sarge or ...

    Article last updated 03/21/2017 - 11:19am.

  5. Katherine King, PhD

    ... effects of inflammatory signaling on bone marrow stem cells . We have known for some time that excessive inflammation can suppress ...

    Grant Recipient last updated 07/07/2017 - 1:09pm.

  6. Drug reduces acute GVHD in unrelated HSCTs

    ... donor myeloablative conditioning hematopoietic stem cell transplant (HSCT).1 In a phase II single-arm study, the ... pro-inflammatory cytokines, regulated antigen-presenting cells through induction of indoleamine 2,3-dioxygenase, and enhanced ... higher at day 30 in peripheral blood mononuclear cells from vorinostat-treated patients  compared with similarly treated ...

    Article last updated 02/27/2017 - 1:45pm.

  7. Hematopoietic Stem Cell Regulation by Type I and II Interferons in the Pathogenesis of Acquired Aplastic Anemia

    ... fails to support production of all three lineages of blood cells, which are necessary for tissue oxygenation, infection control, and ... of cases but involves exhaustion of hematopoietic stem cells (HSC), which are usually present in the bone marrow in a dormant ...

    Research Article last updated 10/06/2016 - 9:44am.

  8. Strong results for SAA patients at Johns Hopkins

    ... one's own immune system damages blood-making bone marrow cells, which gradually stop producing red and white blood cells and platelets. ... immune system cells but does not harm the donor's blood stem cells , which create new disease-free blood cells in the patient. ...

    Article last updated 02/07/2017 - 11:05am.

  9. Bone marrow mesenchymal stem cells from aplastic anemia patients preserve functional and immune properties and do not contribute to the pathogenesis of the disease

    ... anemia cases remain idiopathic , and hematopoietic stem cell deficiency and impaired immune responses are hallmark underlying ... marrow failure in aplastic anemia. Mesenchymal stem/stromal cells constitute an essential component of the bone marrow hematopoietic ...

    Research Article last updated 04/23/2014 - 10:09am.

  10. Reduced intensity conditioning and co-transplantation of unrelated peripheral stem cells combined with umbilical cord mesenchymal stem/stroma cells for young patients with refractory severe aplastic anemia.

    ... of unrelated donor peripheral blood stem cells (UD-PBSCs) and umbilical cord mesenchymal/stroma stem cells (UC-MSCs). After FLU + CTX + ATG ± 2GY TBI conditioning, all ...

    Research Article last updated 11/26/2013 - 11:14am.