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  1. Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure

    ... Our ongoing nonmyeloablative allogeneic peripheral blood stem cell (PBSC) transplant protocol (03-H-0170) for patients with ... recipient who had pre-existing allo-antibody to donor red cells from previous transfusions. Also we have excluded another group of ...

    Clinical Trial last updated 04/28/2016 - 9:09am.

  2. Aplastic Anemia 101: Understanding Diagnosis and Treatment

    ... happens when the bone marrow stops making enough red blood cells, white blood cells and platelets for the body. Aplastic anemia ... common treatments such as immunosuppressive drug therapy, stem cell transplantation, and supportive therapies like blood transfusions. He ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  3. Aplastic Anemia 101: Understanding Diagnosis and Treatment

    ... happens when the bone marrow stops making enough red blood cells, white blood cells and platelets for the body. Aplastic anemia can be ... treatments such as immunosuppressive drug therapy , stem cell transplantation, and supportive therapies like blood transfusions. He ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  4. Understanding Prognosis in MDS

    ... the marrow is trying to make the correct amount of all blood cells as evidenced by the high degree of cellular activity—red blood cells, ... prognosis may suggest a more risky therapy, such as a stem cell transplant , be tried. A better prognosis that indicates a longer ...

    Interview last updated 05/02/2012 - 4:36pm.

  5. Supportive Care

    ... cause your bone marrow to produce more blood cells. They may be helpful for some patients, but they do not replace ... a family member) is willing and able to donate matching stem cells to you ...

    Page last updated 08/29/2013 - 4:20pm.

  6. Matthew J. Walter, MD

    ... Professor Department of Medicine Oncology Division, Stem Cell Biology Section, Department of Genetics ... of genes that are important for splicing together RNA in cells were found to be mutated in up to 57% of MDS patients. How these ...

    Grant Recipient last updated 08/18/2014 - 10:07am.

  7. Clinical Trials Report for February 2015

    ... Study Coordinator Allogeneic Stem Cell Transplantation for Patients With Severe Aplastic Anemia For ... studied. hATG is made from horse blood and targets immune cells known as T-lymphocytes. Since T-lymphocytes are believed to be involved ...

    Page last updated 01/29/2015 - 10:10am.

  8. Extended Dosing With Eltrombopag for Severe Aplastic Anemia

    ... treated with immunosuppressive drug regimens or allogeneic stem cell transplantation. However, 20-40% of patients are ineligible for ... of more primitive bone marrow stem and progenitor cells in vitro and in animal models, suggesting it could have an impact of ...

    Clinical Trial last updated 04/26/2016 - 9:36am.

  9. Randomized Trial of Lenalidomide, Bortezomib, Dexamethasone vs High-Dose Treatment With SCT in MM Patients up to Age 65 (DFCI 10-106)

    ... and cyclophosphamide , the drugs used during stem cell collection and transplant, are also approved by the FDA. Melphalan is ... <50,000/mm3, within 21 days of registration ANC <1,000 cells/mm3, within 21 days of registration Hemoglobin <8 g/dL, ...

    Clinical Trial last updated 05/23/2016 - 3:45pm.

  10. Prognostic value of telomere attrition in patients with aplastic anemia

    ... markedly over past 40 years due to advances in hematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy (IST). ... protect the chromosome, when the telomeres are shorter, the cells’ chromosomes are at greater risk for damage and thus disease. Telomeres ...

    Research Review last updated 05/02/2016 - 9:25am.