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  1. Abatacept Reduced Intensity for Non-Malignant Diseases (Aba NMD)

    ... Purpose:  Allogeneic hematopoietic stem cell transplantation (HSCT) represents the only viable cure for children ... from graft versus host disease (GVHD), driven by donor T cells recognizing and reacting against disparate host antigens. This trial is ...

    Clinical Trial last updated 04/27/2016 - 2:40pm.

  2. Allo HSCT Using RIC for Hematological Diseases

    ... regimen followed by a related or unrelated donor stem cell infusion. The primary objective is to evaluate rates of acute ... Mycophenolate Mofetil Biological: Peripheral Blood Stem Cells On day 0, patients will receive an allogeneic transplant using PBSC ...

    Clinical Trial last updated 05/02/2016 - 9:29am.

  3. Sapacitibine shows promise for high-risk MDS patients

    ... factors, to intensive therapy with allogeneic hematopoietic stem cell transplantation (HSCT). Treatment selection should be based on the ... can help decrease the growth of abnormal bone marrow cells and  restore gene expression.  Failure of the hypomethylating agents, ...

    Research Review last updated 05/02/2016 - 9:30am.

  4. Safety and Efficacy of Patient's Own AD-MSC and AD-HSC Transplantation in Patients With Severe Aplastic Anemia

    ... can be obtained in allogeneic blood or bone marrow stem cell transplantation using an human leukocyte antigen ( HLA ... (ATG) Procedure: Adipose derived mesenchymal stem cells ( AD-MSCs) Procedure: AD-MSC transdifferentiated HSCs (AD-HSCs) ...

    Clinical Trial last updated 04/08/2016 - 11:25pm.

  5. Recurrent and Secondary MDS

    ... after medical treatments, and even after an allogeneic stem cell transplant . So, I think of recurrent MDS to mean progression or ... low blood counts, and at times, we see a population of MDS cells that can develop. This may also occur related to other bone marrow ...

    Interview last updated 10/24/2012 - 1:12pm.

  6. B. Douglas Smith, MD

    ... on studying the impact of the treatment on the leukemic stem cell in hopes of limiting these cells’ roles in treatment failure.   Dr. Smith serves on the NCCN ...

    Bio last updated 03/11/2016 - 1:41pm.

  7. Issues for Parents of Pediatric Bone Marrow Failure Patients

    ... does a doctor decide if a child is a good candidate for a stem cell transplantation? DR. MARGOLIS: We will call it a bone ... for lack of a better word. You can get your blood stem cells from either bone marrow, cord blood, or peripheral blood, and there ...

    Page last updated 06/20/2011 - 12:10pm.

  8. Chao-Yie Yang

    ... key proteins that prevent programmed cell death in cancer cells. One compound, AT-406, is currently entering a phase 2 clinical trial ... (GvHD) for treating patients receiving hematopoietic stem cell transplantation with a collaborator at Indiana University. The ...

    Bio last updated 03/11/2016 - 1:41pm.

  9. Treating Higher-Risk Myelodysplastic Syndromes

    ... marrow , any chromosomal abnormalities seen in the MDS cells, and the degree of low blood counts, indicating if the red blood cells, ... the eventual goal or desired treatment is an allogeneic stem cell transplant . Depending on patient’s age and the stage or status ...

    Interview last updated 05/18/2012 - 1:55pm.

  10. Eltrombopag: Recent Discoveries on Potential New Applications for Aplastic Anemia

    ... we knew that it could potentially be stimulating the stem cells – these are the cells in the bone marrow that give rise to all ...

    Interview last updated 02/14/2014 - 2:01pm.