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  1. Lisa Minter, MD

    ... aplastic anemia , results in the destruction of blood stem and progenitor cells in the bone marrow. One subset of these cells, CD4 T cells, requires the ...

    Grant Recipient last updated 08/18/2014 - 10:07am.

  2. BMT Meant 'It Could Finally Be Over '

    ... my hematocrit (the volume percentage of red blood cells in my body), had gone down recently and it had been almost two weeks ... and Beyond In January 2014, I received a stem cell transplant from an unrelated donor . My transplant ended ...

    Patient Chronicle last updated 05/10/2016 - 3:28pm.

  3. Eltrombopag in aplastic anemia

    ... chemotherapy ) plus healthy hematopoietic progenitor cells; or with lymphotoxic drugs, such as ATG and cyclosporine . ... who fail horse ATG still respond to alternative IST), or a stem cell depletion in the absence of active immune attack. The latter ...

    Research Review last updated 05/02/2016 - 9:13am.

  4. Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure

    ... Our ongoing nonmyeloablative allogeneic peripheral blood stem cell (PBSC) transplant protocol (03-H-0170) for patients with ... recipient who had pre-existing allo-antibody to donor red cells from previous transfusions. Also we have excluded another group of ...

    Clinical Trial last updated 04/28/2016 - 9:09am.

  5. Amer Zeidan, M.D.

    ... the patient’s own immune system to attack the cancer cells. Dr. Zeidan and his colleagues designed and initiated an ongoing trial ... and decitabine ) and are not candidates for stem cell transplantation. Studies have found that cancer cells can block the ...

    Bio last updated 03/11/2016 - 1:41pm.

  6. Randomized Trial of Lenalidomide, Bortezomib, Dexamethasone vs High-Dose Treatment With SCT in MM Patients up to Age 65 (DFCI 10-106)

    ... and cyclophosphamide , the drugs used during stem cell collection and transplant, are also approved by the FDA. Melphalan is ... <50,000/mm3, within 21 days of registration ANC <1,000 cells/mm3, within 21 days of registration Hemoglobin <8 g/dL, ...

    Clinical Trial last updated 05/23/2016 - 3:45pm.

  7. Combined Bone Marrow and Renal Transplantation for Hematologic Disorders With End Stage Renal Disease

    ... or other hematologic disorder for which hematopoietic stem cell transplantation would be ordinarily indicated and the reversal of ... a related donor Donor bone marrow (> 2 x 10e8 nucleated cells/kg of recipient body weight) is prepared for infusion according to the ...

    Clinical Trial last updated 06/06/2016 - 3:04pm.

  8. Extended Dosing With Eltrombopag for Severe Aplastic Anemia

    ... treated with immunosuppressive drug regimens or allogeneic stem cell transplantation. However, 20-40% of patients are ineligible for ... of more primitive bone marrow stem and progenitor cells in vitro and in animal models, suggesting it could have an impact of ...

    Clinical Trial last updated 04/26/2016 - 9:36am.

  9. Recurrent and Secondary MDS

    ... after medical treatments, and even after an allogeneic stem cell transplant . So, I think of recurrent MDS to mean progression or ... low blood counts, and at times, we see a population of MDS cells that can develop. This may also occur related to other bone marrow ...

    Interview last updated 10/24/2012 - 1:12pm.

  10. Prognostic value of telomere attrition in patients with aplastic anemia

    ... markedly over past 40 years due to advances in hematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy (IST). ... protect the chromosome, when the telomeres are shorter, the cells’ chromosomes are at greater risk for damage and thus disease. Telomeres ...

    Research Review last updated 05/02/2016 - 9:25am.