Search | Page 38 | Aplastic Anemia and MDS International Foundation

Search

Search results

  1. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... glycan anchor (PIG-A) in a multipotent hematopoietic stem cell (HSC), with clonal expansion of the mutated HSC. The mutation causes ... in the synthesis of glycosylphosphatidylinositol (GPI). In cells derived from normal HSCs, the complement regulatory proteins CD55 and ...

    Research Article last updated 05/14/2013 - 3:28pm.

  2. The Transplantation Procedure

    ... What medical tests and exams happen before a stem cell transplant ? Your doctors will want to make sure you're ... in order to allow for engraftment of donor stem cells .  To prepare for the transplant, you may first be given ...

    Page last updated 05/14/2015 - 10:39am.

  3. Transplantation Update

    ... toxicity from the regimens used to prepare patients for stem cell transplants regardless of who the donor is or the source of stem cells used.  There has been a focus on the low or reduced intensity ...

    Interview last updated 05/14/2015 - 2:42pm.

  4. Common polymorphic deletion of glutathione S-transferase theta predisposes to acquired aplastic anemia: Independent cohort and meta-analysis of 609 patients.

    ... syndrome, caused by autoimmune destruction of hematopoietic stem and progenitor cells. Epidemiologic studies suggest that environmental exposures and metabolic ...

    Research Article last updated 07/09/2013 - 2:58pm.

  5. Guidelines for the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria and related disorders by flow cytometry.

    ... hemoglobinuria (PNH) is a rare hematopoietic stem cell disorder characterized by a somatic mutation in the PIGA ... flow cytometry is the method of choice for identifying cells deficient in GPI-linked proteins and is, therefore, necessary for the ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. Transplantation Basics

    ... Is it correct to say that stem cell transplantation is a process in which stem cells are gathered from either bone marrow , umbilical cord blood, ...

    Interview last updated 04/05/2013 - 2:33pm.

  7. Paroxysmal nocturnal hemoglobinuria from bench to bedside

    ... therapy. PNH originates from a multipotent hematopoietic stem cell (HSC) that acquires a somatic mutation in a gene called ... regulatory proteins; their absence on the surface of PNH cells leads to complement-mediated hemolysis . The release of free ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. PNH: Causes

    ... ( mutation ) in the PIG-A gene of a single stem cell in the bone marrow . This gene allows a substance called ... (GPI) to help certain proteins stick to cells. Here are the steps that lead to PNH: The abnormal stem cell makes copies of or "clones" itself. This leads to a whole population ...

    Page last updated 06/29/2015 - 8:44am.

  9. Myelodysplastic syndromes: revisiting the role of the bone marrow microenvironment in disease pathogenesis

    ... likely depends on interplay between aberrant hematopoietic cells and their microenvironment. How niche cells play a role in disease ... is poorly defined, but the delineation of the hematopoietic stem cell niche and the ability to interrogate its role in hematopoietic ...

    Research Article last updated 04/24/2012 - 2:23pm.

  10. Allogeneic transplantation for aplastic anemia

    ... -matched sibling, unrelated donor , hematopoietic stem cell transplantation. RESULTS: Survival after HLA-matched ... complications. The use of peripheral blood progenitor cells has also contributed to higher GVHD risks and consequently excess ...

    Research Article last updated 07/03/2012 - 2:57pm.