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  1. Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure

    ... Our ongoing nonmyeloablative allogeneic peripheral blood stem cell (PBSC) transplant protocol (03-H-0170) for patients with ... recipient who had pre-existing allo-antibody to donor red cells from previous transfusions. Also we have excluded another group of ...

    Clinical Trial last updated 04/28/2016 - 9:09am.

  2. About Bone Marrow Failure

    ... bone marrow .  It is the "factory" that makes blood cells.  Bone marrow contains special cells called stem cells . These blood-forming stem cells grow and mature into the three ...

    Page last updated 07/01/2013 - 4:51pm.

  3. Extended Dosing With Eltrombopag for Severe Aplastic Anemia

    ... treated with immunosuppressive drug regimens or allogeneic stem cell transplantation. However, 20-40% of patients are ineligible for ... of more primitive bone marrow stem and progenitor cells in vitro and in animal models, suggesting it could have an impact of ...

    Clinical Trial last updated 04/26/2016 - 9:36am.

  4. Prognostic value of telomere attrition in patients with aplastic anemia

    ... markedly over past 40 years due to advances in hematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy (IST). ... protect the chromosome, when the telomeres are shorter, the cells’ chromosomes are at greater risk for damage and thus disease. Telomeres ...

    Research Review last updated 05/02/2016 - 9:25am.

  5. HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy (RAFA)

    ... neupogen Biological: Peripheral blood stem cell The source of stem cells for all patients will be peripheral blood stem cells (PBSC) induced and ...

    Clinical Trial last updated 05/09/2016 - 3:19pm.

  6. Adoptive Transfer of Haplo-identical DLI for AML and MDS

    ... may be a tolerable alternative to allogeneic hematopoietic stem cell transplantation (alloHSCT) for elderly patients, the Investigator ... at a dose of 1x10^8 cluster of differentiation 3 (CD3+) cells; however, due to logistics of planning infusions with staffing, donor ...

    Clinical Trial last updated 05/03/2016 - 9:59am.

  7. Amer Zeidan, M.D.

    ... the patient’s own immune system to attack the cancer cells. Dr. Zeidan and his colleagues designed and initiated an ongoing trial ... and decitabine ) and are not candidates for stem cell transplantation. Studies have found that cancer cells can block the ...

    Bio last updated 03/11/2016 - 1:41pm.

  8. SGI-110 With Donor Lymphocyte Infusion (DLI) for Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndrome (MDS) Relapsing Post Allogeneic Stem Cell Transplantation (AlloSCT)

    ... study is to learn if giving donor lymphocyte cells and SGI-110 will help control AML and MDS. The safety of this treatment ... by vein over about 10-30 minutes. Other Names: DLI Stem cell transplantation AlloSCT ...

    Clinical Trial last updated 04/29/2016 - 12:20pm.

  9. Allo HSCT Using RIC for Hematological Diseases

    ... regimen followed by a related or unrelated donor stem cell infusion. The primary objective is to evaluate rates of acute ... Mycophenolate Mofetil Biological: Peripheral Blood Stem Cells On day 0, patients will receive an allogeneic transplant using PBSC ...

    Clinical Trial last updated 05/02/2016 - 9:29am.

  10. Abatacept Reduced Intensity for Non-Malignant Diseases (Aba NMD)

    ... Purpose:  Allogeneic hematopoietic stem cell transplantation (HSCT) represents the only viable cure for children ... from graft versus host disease (GVHD), driven by donor T cells recognizing and reacting against disparate host antigens. This trial is ...

    Clinical Trial last updated 04/27/2016 - 2:40pm.