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  1. Resources to Help

    ... the needs of patients facing a  bone marrow , blood stem cell or umbilical  cord blood transplant . In addition to high-quality ... the exchange of high quality haematopoietic  stem cells  for clinical transplantation worldwide and to promote the interests of ...

    Topic section last updated 11/15/2017 - 2:31pm.

  2. New positive results for GVHD treatment

    ... treat a common and serious complication of a type of stem cell transplant , findings from a small clinical trial show. ... after receiving a transplant of donated blood stem cells , known as an allogeneic transplant. The patients’ ...

    Article last updated 01/12/2017 - 11:10am.

  3. A retrospective study of paroxysmal nocturnal hemoglobinuria in pediatric and adolescent patients

    Journal Title:  Blood Cells Mol Dis Primary Author:  ... whereas four patients with PNH/BMD underwent hematopoietic stem cell transplantation. Our series confirm that the most frequent ...

    Research Article last updated 05/02/2017 - 10:42am.

  4. Updates on the pathophysiology and treatment of aplastic anemia: a comprehensive review.

    ... commentary: Immune-mediated destruction of hematopoietic stem and progenitor cells, leading to a marrow devoid of hematopoietic elements, and peripheral ...

    Research Article last updated 05/02/2017 - 10:13am.

  5. Dysregulated miR34a/diacylglycerol kinase ζ interaction enhances T-cell activation in acquired aplastic anemia

    ... which involves active destruction of hematopoietic stem cells and progenitors by cytotoxic T cells in the bone marrow. Aberrant ...

    Research Article last updated 01/24/2017 - 10:08am.

  6. Impaired proliferative potential of bone marrow mesenchymal stem cells in patients with myelodysplastic syndromes is associated with abnormal WNT signaling pathway

    Journal Title:  Stem Cells Dev Primary Author:  ... It has been shown that bone marrow mesenchymal stem cells (MSCs) from patients with myelodysplastic syndromes ...

    Research Article last updated 04/09/2014 - 9:36am.

  7. New study hails test to weigh SCT for MDS

    ... Link:  Genetic Profiling Can Guide Stem Cell Transplantation for Patients with Myelodysplastic Syndrome, Study ... report that genetically profiling a patient’s blood cells, while factoring in a patient’s age and other factors, can predict the ...

    Article last updated 02/09/2017 - 9:03am.

  8. Focal Adhesion Kinase as a Potential Target in AML and MDS

    ... growth, survival, invasion, metastasis, gene expression, and stem cell self-renewal, its expression and function in myeloid leukemia are not ... (P = 5.42 x 10-20) and CD34+ CD38- MDS (P = 7.62 x 10-9) cells compared to normal CD34+ cells. MDS patients with higher FAK in CD34+ ...

    Research Article last updated 03/22/2017 - 10:20am.

  9. Identifying bone marrow failure in children

    ... a child looks sick, the marrow's ability to produce blood cells can be so weakened that it could be too late—or at least much more ... life-threatening conditions requiring a hematopoietic stem cell transplant to mild cases that are treated either medically or ...

    Article last updated 03/15/2017 - 10:08am.

  10. How I treat acquired aplastic anemia

    ... and mortality. Immune destruction of hemopoietic stem cells , plays an important role in the pathogenesis, as shown by successful ...

    Research Article last updated 02/03/2017 - 9:51am.