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  1. New positive results for GVHD treatment

    ... treat a common and serious complication of a type of stem cell transplant , findings from a small clinical trial show. ... after receiving a transplant of donated blood stem cells , known as an allogeneic transplant. The patients’ ...

    Article last updated 01/12/2017 - 11:10am.

  2. Dysregulated miR34a/diacylglycerol kinase ζ interaction enhances T-cell activation in acquired aplastic anemia

    ... which involves active destruction of hematopoietic stem cells and progenitors by cytotoxic T cells in the bone marrow. Aberrant ...

    Research Article last updated 01/24/2017 - 10:08am.

  3. Katherine King, PhD

    ... effects of inflammatory signaling on bone marrow stem cells . We have known for some time that excessive inflammation can suppress ...

    Grant Recipient last updated 07/07/2017 - 1:09pm.

  4. New study hails test to weigh SCT for MDS

    ... Link:  Genetic Profiling Can Guide Stem Cell Transplantation for Patients with Myelodysplastic Syndrome, Study ... report that genetically profiling a patient’s blood cells, while factoring in a patient’s age and other factors, can predict the ...

    Article last updated 02/09/2017 - 9:03am.

  5. Focal Adhesion Kinase as a Potential Target in AML and MDS

    ... growth, survival, invasion, metastasis, gene expression, and stem cell self-renewal, its expression and function in myeloid leukemia are not ... (P = 5.42 x 10-20) and CD34+ CD38- MDS (P = 7.62 x 10-9) cells compared to normal CD34+ cells. MDS patients with higher FAK in CD34+ ...

    Research Article last updated 03/22/2017 - 10:20am.

  6. Identifying bone marrow failure in children

    ... a child looks sick, the marrow's ability to produce blood cells can be so weakened that it could be too late—or at least much more ... life-threatening conditions requiring a hematopoietic stem cell transplant to mild cases that are treated either medically or ...

    Article last updated 03/15/2017 - 10:08am.

  7. Transplant saves student who thought she had mono

    ... where your bone marrow essentially stops producing blood cells for your body. At first, I thought, Fine! I’ll just take a few ... transplant, which replaced my unhealthy blood-forming stem cells with the healthy ones from my donor. The first 100 days ...

    Article last updated 03/06/2017 - 2:37pm.

  8. SAA patient finds unrelated donor match in 2 weeks

    ... in which bone marrow does not make enough blood cells. He’s been in and out of hospitals countless times for transfusions ... between 18 and 44, and want to register as a bone marrow/stem cell donor can do it at join.bethematch.org/hope4sarge or ...

    Article last updated 03/21/2017 - 11:19am.

  9. How I treat acquired aplastic anemia

    ... and mortality. Immune destruction of hemopoietic stem cells , plays an important role in the pathogenesis, as shown by successful ...

    Research Article last updated 02/03/2017 - 9:51am.

  10. Update on the diagnosis and management of paroxysmal nocturnal hemoglobinuria

    ... of glycosyl phosphatidylinositol anchor protein-deficient cells. But PNH is clinically heterogeneous, with some patients having a disease ... nonmalignant clonal disease of the hematopoietic stem cells . Bone marrow failure complicates management of PNH because ...

    Research Article last updated 01/26/2017 - 11:03am.