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  1. Patient Trusts Her Instincts in Finding the Right Treatment

    ... me “If you were my mother I would prepare you for a stem cell transplant .”  When I first got to CTCA, I started on ... a five day/1-hour infusion.  It dropped my white blood cells very low, my red cell count to 6.7 and my platelets to 11.  I had to get ...

    Patient Chronicle last updated 05/10/2018 - 11:01am.

  2. The Challenge of Treating Myelodysplastic Syndromes/Myeloproliferative Neoplasms.

    ... and proliferative features, arising from hematopoietic stem cells . MDS/MPN are neither MDS nor MPN but a distinct World Health ...

    Research Article last updated 09/11/2017 - 8:45am.

  3. Impaired proliferative potential of bone marrow mesenchymal stem cells in patients with myelodysplastic syndromes is associated with abnormal WNT signaling pathway

    ... Journal Title:  Stem Cells Dev Primary Author:  ...

    Research Article last updated 04/09/2014 - 9:36am.

  4. Retired MDS Patient Living Life to the Fullest Since Transplant

    ... and it showed something was off with my white and red blood cells. I had a repeat blood test in September and it improved slightly, but my ... as my primary caregiver. In January 2011, I received a stem cell bone marrow transplant from an unrelated donor from ...

    Patient Chronicle last updated 04/26/2018 - 10:43am.

  5. On the horizon: Man-made bone marrow

    ... in combination with drugs, to kill off any existing stem cells in the patient’s bone marrow. This pre-treatment is meant to ...

    Article last updated 05/09/2017 - 10:41am.

  6. Clinical trial reveals genetic fault that reduces the effectiveness of leukemia treatment

    ... people had a significantly worse outcome if their cancer cells carried a mutation to the CDKN2A gene. The results may help ... involves intensive chemotherapy followed by a stem cell transplant . However high dose chemotherapy is poorly tolerated by ...

    Research Article last updated 09/29/2017 - 10:32am.

  7. SOHO State of the Art Update and Next Questions: Biology and Treatment of Myelodysplastic Syndromes

    ... of innate immune signaling (i.e. myeloid derived suppressor cells) and the NLRP3 inflammasome in hematopoietic stem/progenitor cells play a central role in the biology of MDS, leading to ...

    Research Article last updated 10/20/2017 - 9:14am.

  8. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

    ... a rare acquired disorder originating from hematopoietic stem cells and is a life-threating disease characterized by intravascular ...

    Research Article last updated 07/27/2017 - 2:06pm.

  9. FDA approves first drug to treat GVHD

    ... potentially fatal and common side effect of cancer-related stem cell transplants. The approval covers the use of ibrutinib in patients ... activity of a protein known as BTK, which is present in B cells  and other types of immune cells. GVHD occurs when transplanted ...

    Article last updated 08/29/2017 - 7:55am.

  10. MDS expert finds promising antibody

    ... Researchers find new way to target blood stem cell cancers Article ... CD99, occurs more frequently than normal on stem cells responsible for blood cancers, including acute myeloid leukemia (AML) ...

    Article last updated 01/26/2017 - 1:14pm.