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  1. Good outcome of haploidentical hematopoietic SCT as a salvage therapy in children and adolescents with acquired severe aplastic anemia

    ... and basiliximab for GVHD prophylaxis. Mesenchymal stem cells derived from unrelated umbilical cord were infused on day 1. ...

    Research Article last updated 09/04/2014 - 11:22am.

  2. Aplastic Anemia: Alternative Immunosuppressive Treatments and Eltrombopag. A report from the 2014 EBMT Educational Meeting from the Severe Aplastic Anaemia and Infectious Diseases Working Parties

    ... protection and/or stimulation of residual hematopoietic stem cells by eltrombopag seem an interesting strategy which, once combined ...

    Research Article last updated 03/02/2015 - 11:53am.

  3. Oral Azacitidine (CC-486) for the Treatment of Myelodysplastic Syndromes and Acute Myeloid Leukemia

    ... therapy for patients with AML not eligible for stem cell transplant , and as maintenance therapy for patients with MDS or ... of azacitidine by increasing exposure to cycling malignant cells. In early phase trials, oral azacitidine (CC-486) in extended dosing ...

    Research Article last updated 12/09/2015 - 8:49am.

  4. Allogeneic BM transplantation for the treatment of aplastic anemia: current results and expanding donor possibilities

    ... or from an unrelated one, the use of peripheral blood stem cells must be strongly discouraged because they have been systematically ...

    Research Article last updated 01/07/2014 - 12:31pm.

  5. An update on the treatment of myelodysplastic syndromes.

    ... heterogeneous clonal disorders of myeloid hematopoietic stem cells affecting about 300,000 people worldwide. Ineffective ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders

    ... disorder characterized by the expansion of hematopoietic stem cells and progeny mature blood cells which are deficient in some surface ...

    Research Article last updated 10/02/2012 - 10:00am.

  7. SNP array-based karyotyping: differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes.

    ... In aplastic anemia (AA), contraction of the stem cell pool may result in oligoclonality while in myelodysplastic ... aberrations expands and outcompetes normal stem cells . We analyzed patients with AA (N=93) and hypocellular MDS ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. Myelodysplastic syndrome hematopoietic stem cell

    ... syndromes (MDSs) are clonal hematopoietic stem cell (HSC) malignancies that are characterized by ineffective ... alter the natural history of this disease. Allogeneic stem-cell transplantation for high-risk MDS is becoming the only curative ... a molecular portrait of the whole genome of MDS CD34(+) cells, including identifying altered signaling pathways and altered ...

    Research Article last updated 11/05/2012 - 10:21am.

  9. Effect of stem cell source on outcomes after unrelated donor transplantation in severe aplastic anemia

    ... now approximately 75%. Increasing use of peripheral blood stem and progenitor cells (PBPCs) instead of BM as a graft source prompted us to compare outcomes ...

    Research Article last updated 10/11/2011 - 5:58pm.

  10. Spontaneous remision of aplastic anemia occurring during a pregnancy

    ... is a rare disease caused by destruction of pluripotent stem cells in bone marrow . The occurrence of aplastic anemia during ...

    Research Article last updated 07/31/2012 - 2:12pm.