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  1. Good outcome of haploidentical hematopoietic SCT as a salvage therapy in children and adolescents with acquired severe aplastic anemia

    ... and basiliximab for GVHD prophylaxis. Mesenchymal stem cells derived from unrelated umbilical cord were infused on day 1. ...

    Research Article last updated 09/04/2014 - 11:22am.

  2. MicroRNAs in the pathogenesis of myelodysplastic syndromes and myeloid leukaemia

    ... in self-renewal and transformation of haematopoietic stem cells , as well as their ability to induce epigenetic alterations in the ...

    Research Article last updated 06/02/2014 - 10:35am.

  3. Rasha Iqbal's Transplant Experience Amplifies Her Desire for Research Career

    ... and radiation? Can we regenerate the patient’s own stem cells without requiring a transplant?”  As a curious person, I am ...

    Patient Chronicle last updated 11/13/2015 - 11:27am.

  4. Coleman Lindsley, MD, PhD

    ... telomere length and telomerase gene mutations on allogeneic stem cell transplantation outcomes in myelodysplastic syndromes ... we propose to measure telomere length in the blood cells of MDS patients and correlate with clinical and genetic information. ...

    Grant Recipient last updated 06/05/2017 - 11:04am.

  5. Allogeneic BM transplantation for the treatment of aplastic anemia: current results and expanding donor possibilities

    ... or from an unrelated one, the use of peripheral blood stem cells must be strongly discouraged because they have been systematically ...

    Research Article last updated 01/07/2014 - 12:31pm.

  6. An update on the treatment of myelodysplastic syndromes.

    ... heterogeneous clonal disorders of myeloid hematopoietic stem cells affecting about 300,000 people worldwide. Ineffective ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders

    ... disorder characterized by the expansion of hematopoietic stem cells and progeny mature blood cells which are deficient in some surface ...

    Research Article last updated 10/02/2012 - 10:00am.

  8. Interviews with the Experts Transplantation & GVHD: What Patients Need to Know

    Why is stem cell transplantation considered a treatment option for many aplastic anemia , MDS or PNH patients? Hematopoietic stem cell transplantation (HSCT) involves the intravenous or IV (injected into a vein) infusion of stem cells to reestablish hematopoietic (blood forming) function in patients ...

    Interview last updated 09/30/2014 - 11:07am.

  9. SNP array-based karyotyping: differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes.

    ... In aplastic anemia (AA), contraction of the stem cell pool may result in oligoclonality while in myelodysplastic ... aberrations expands and outcompetes normal stem cells . We analyzed patients with AA (N=93) and hypocellular MDS ...

    Research Article last updated 10/11/2011 - 5:58pm.

  10. Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review

    ... (PNH) is an acquired disorder of the hematopoietic stem cell that makes blood cells more sensitive to the action of complement. Patients experience ...

    Research Article last updated 04/07/2015 - 12:36pm.