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  1. Disease progression in myelodysplastic syndromes: do mesenchymal cells pave the way?

    ... Journal Title:  Cell Stem Cell Primary Author:  ... permissive niche has been implicated. In this issue of Cell Stem Cell, Medyouf et al. (2014) provide insights into the role of the niche ...

    Research Article last updated 06/19/2014 - 1:01pm.

  2. Effect of lenalidomide treatment on clonal architecture of myelodysplastic syndromes without 5q deletion

    ... clonal architecture of single CD34+CD38- hematopoietic stem cells was also determined in 5 cases. Four genes had a mutation ...

    Research Article last updated 04/29/2016 - 11:33am.

  3. Allogeneic stem cell transplantation in myelodysplastic syndromes: does pretransplant clonal burden matter?

    ... syndromes (MDS) is allogeneic hematopoietic stem cell transplantation (alloSCT). As alloSCT confers both a short-term ... treatment. Randomized data are lacking. Most hematopoietic cells in patients with MDS are clonal, even in cases without increased marrow ...

    Research Article last updated 04/29/2016 - 10:22am.

  4. NHLBI profiles a member of the Foundation’s patient community.

    ... tissue inside the bones — from making enough red blood cells, which carry oxygen to the different parts of the body; white blood ... therapy. The hope: that the treatment would allow the stem cells in her bone marrow to grow and produce normal blood cell levels. ...

    Article last updated 06/13/2016 - 1:51pm.

  5. Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells

    ... and isogenic karyotypically normal induced pluripotent stem cells (iPSCs) from hematopoietic cells of MDS patients and show that the ...

    Research Article last updated 04/08/2015 - 9:33am.

  6. Myelodysplastic syndromes with 5q deletion: pathophysiology and role of lenalidomide

    ... Myelodysplastic syndrome (MDS) is a hematopoietic stem cell disorder primarily affecting CD34+ cells, characterized by ineffective hematopoiesis , often transforming ...

    Research Article last updated 04/17/2014 - 11:29am.

  7. CSNK1A1 mutations and gene expression analysis in myelodysplastic syndromes with del(5q).

    ... β-catenin activation and expansion of haematopoietic stem cells (HSC). We have screened a large cohort of 104 del(5q) MDS patients ...

    Research Article last updated 07/08/2015 - 11:46am.

  8. Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH).

    ... Glycan class A (PIG-A) gene in the hematopoietic stem cells (HSC) of patients. The presence of these mutations leads to ...

    Research Article last updated 10/22/2013 - 3:44pm.

  9. Eltrombopag and improved hematopoiesis in refractory aplastic anemia

    ... cytopenia and a profound deficit in hematopoietic stem cells and progenitor cells. Thrombopoietin may increase the number of ...

    Research Article last updated 07/31/2012 - 2:24pm.

  10. Advances in the molecular pathology of MDS

    ... other than replacement of the bone marrow with stem cells from a healthy matched donor, is unlikely to achieve cure as patients ...

    Research Review last updated 05/02/2016 - 9:44am.