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  1. Mutations of myelodysplastic syndromes (MDS): An update

    ... a heterogeneous pre-malignant disorder of hematopoietic stem cells , through sequencing of several pathway genes has unveiled molecular ...

    Research Article last updated 09/19/2016 - 11:02am.

  2. First-in Human Clinical Transplant Trial for Severe Aplastic Anemia

    ... How did the idea to study a particular type of stem cell transplant originate? The idea for the study in question is ... occurred with infections and graft rejection because the T cells that come with the transplant must be depleted, or you will encounter ...

    Interview last updated 10/04/2017 - 1:36pm.

  3. Platelet drug shows clinical benefits for severe, unresponsive aplastic anemia

    ... of platelets and it now appears also hematopoietic stem cells . Eltrombopag can be given orally and has been approved by the FDA for ...

    Interview last updated 07/06/2012 - 3:42pm.

  4. AAMDSIF partners on new MDS patient resource

    ... are the result of genetic alterations that cause blood stem cells to become abnormal, rendering bone marrow unable to create ...

    Article last updated 06/28/2016 - 12:43pm.

  5. Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuria

    ... results from expansion of a clone of hematopoietic cells that, as a consequence of an inactivating mutation of the ... from T-cell-mediated auto-immune damage to hematopoietic stem cells , with the GPI molecule as target. Indeed, GPI-specific CD8+ T ...

    Research Article last updated 06/07/2016 - 10:56am.

  6. Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... ( PNH ) is a rare blood disease that causes red blood cells to break apart. Doctors call this breaking apart " hemolysis ." It ... inside certain bones. Marrow contains blood-forming stem cells that make copies of themselves to create all 3 types of blood ...

    Page last updated 09/30/2017 - 11:34am.

  7. Patient Inspires Workplace Giving

    ... tests, it was decided that I was a good candidate for a stem cell transplant . My sister was tested and found to be a fully matched ... about a year of preparation, I received my new stem cells on June 8, 2011, almost 5 years ago. After an inpatient stay of ...

    Patient Chronicle last updated 06/28/2016 - 8:12am.

  8. Pexmetinib: a novel dual inhibitor of Tie-2 and p38 MAPK with efficacy in preclinical models of myelodysplastic syndromes and acute myeloid leukemia

    ... that elevation of angiopoietin-1 in myelodysplastic CD34+ stem-like cells is associated with higher risk disease and reduced overall survival in ...

    Research Article last updated 07/18/2016 - 11:12am.

  9. Swabbing leaps into the record books, sort of

    ... have already donated either bone marrow or blood stem cells to save the life of someone with cancer, and to encourage more people ...

    Article last updated 10/04/2016 - 2:38pm.

  10. Novel strategies to prevent relapse after allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia and myelodysplastic syndromes

    ... of haematological neoplasms after allogeneic haematopoietic stem cell transplantation (HSCT) remains one of the leading causes of death. ... interventions to impair growth of residual clonal cells and post-HSCT immune-mediated interventions to enhance the ...

    Research Article last updated 03/02/2015 - 1:25pm.