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  1. A prospective multicenter study of paroxysmal nocturnal hemoglobinuria cells in patients with bone marrow failure.

    ... hemoglobinuria (PNH), a rare clonal hematopoietic stem cell disorder, is characterized by chronic, uncontrolled complement ...

    Research Article last updated 11/21/2013 - 11:54am.

  2. First-line matched related donor hematopoietic stem cell transplantation compared to immunosuppressive therapy in acquired severe aplastic anemia.

    ... immune-mediated functional impairment of hematopoietic stem cells . Transplantation of these cells is a first-line treatment option if ...

    Research Article last updated 10/11/2011 - 5:58pm.

  3. A Prospective Multicenter Study of Paroxysmal Nocturnal Hemoglobinuria Cells in Patients with Bone Marrow Failure.

    ... hemoglobinuria (PNH), a rare clonal hematopoietic stem cell disorder, is characterized by chronic, uncontrolled complement ...

    Research Article last updated 10/22/2013 - 3:42pm.

  4. Novel strategies to prevent relapse after allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia and myelodysplastic syndromes

    ... of haematological neoplasms after allogeneic haematopoietic stem cell transplantation (HSCT) remains one of the leading causes of death. ... interventions to impair growth of residual clonal cells and post-HSCT immune-mediated interventions to enhance the ...

    Research Article last updated 03/02/2015 - 1:25pm.

  5. Personalized medicine for MDS

    ... can also help to detect abnormal clonal populations of cells.  -The results of the bone marrow provide important information that ... for a more intensive treatment, such as allogeneic stem cell transplant , earlier in the course of disease.  This personalized ...

    Research Review last updated 05/02/2016 - 9:44am.

  6. Myelodysplastic Syndromes (MDS)

    ... MDS happens because the bone marrow cells do not develop into mature blood cells. Instead, these blood cells stay ... inside certain bones. Marrow contains blood-forming stem cells that make copies of themselves to create all 3 types of blood ...

    Page last updated 02/27/2017 - 7:36am.

  7. Platelet drug shows clinical benefits for severe, unresponsive aplastic anemia

    ... of platelets and it now appears also hematopoietic stem cells . Eltrombopag can be given orally and has been approved by the FDA for ...

    Interview last updated 07/06/2012 - 3:42pm.

  8. Disease progression in myelodysplastic syndromes: do mesenchymal cells pave the way?

    Journal Title:  Cell Stem Cell Primary Author:  ... permissive niche has been implicated. In this issue of Cell Stem Cell, Medyouf et al. (2014) provide insights into the role of the niche ...

    Research Article last updated 06/19/2014 - 1:01pm.

  9. Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

    ... or constitutively activated in bone marrow hematopoietic stem and progenitor cells. Mounting experimental results indicate that the dysregulation of these ...

    Research Article last updated 04/29/2016 - 11:35am.

  10. CSNK1A1 mutations and gene expression analysis in myelodysplastic syndromes with del(5q).

    ... β-catenin activation and expansion of haematopoietic stem cells (HSC). We have screened a large cohort of 104 del(5q) MDS patients ...

    Research Article last updated 07/08/2015 - 11:46am.