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  1. FDA approves first drug to treat GVHD

    ... potentially fatal and common side effect of cancer-related stem cell transplants. The approval covers the use of ibrutinib in patients ... activity of a protein known as BTK, which is present in B cells  and other types of immune cells. GVHD occurs when transplanted ...

    Article last updated 08/29/2017 - 7:55am.

  2. Jill Minden’s Encounter with Aplastic Anemia

    ... we learned it did not help me. The time had come for a stem cell transplant . My brothers were not a match for me, but thankfully, ... I took it very hard. My doctor said they harvested enough cells from my donor the first time so we could try again. While waiting for ...

    Patient Chronicle last updated 09/05/2017 - 10:57am.

  3. The microenvironment in myelodysplastic syndromes: niche-mediated disease initiation and progression

    ... syndromes (MDS) are clonal disorders of hematopoietic stem and progenitor cells and represent the most common cause of acquired marrow failure. ...

    Research Article last updated 09/13/2017 - 8:25am.

  4. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

    ... a rare acquired disorder originating from hematopoietic stem cells and is a life-threating disease characterized by intravascular ...

    Research Article last updated 07/27/2017 - 2:06pm.

  5. Cotransplantation of bone marrow-derived mesenchymal stem cells in haploidentical hematopoietic stem cell transplantation in patients with severe aplastic anemia: an interim summary for a multicenter phase II trial results

    ... Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) for severe aplastic anemia (SAA) ... incidence of graft failure and GvHD. Mesenchymal stem cells (MSCs) have been shown to support hematopoiesis in vivo and ...

    Research Article last updated 02/01/2017 - 12:30pm.

  6. New study on SCT therapy for SAA, MDS patients

    ... which the bone marrow does not produce enough blood cells for the body, and hypoplastic MDS is characterized by decreased marrow cellularity . Cordin is a variety of stem cell transplantation that uses blood from an umbilical cord. It is a ...

    Article last updated 08/22/2017 - 9:41am.

  7. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

    ... a rare acquired disorder originating from hematopoietic stem cells and is a life-threating disease characterized by intravascular ...

    Research Article last updated 07/11/2017 - 10:43am.

  8. On the horizon: Man-made bone marrow

    ... in combination with drugs, to kill off any existing stem cells in the patient’s bone marrow. This pre-treatment is meant to ...

    Article last updated 05/09/2017 - 10:41am.

  9. John Vasquez, In Treatment at NIH

    ... Health (NIH) himself. He was eventually approved for a stem cell transplant as part of a new clinical trial testing the use of cord-blood stem cells with half-matched stem cells from his brother, Isaiah. Although ...

    Patient Chronicle last updated 12/05/2017 - 10:48am.

  10. First-in Human Clinical Transplant Trial for Severe Aplastic Anemia

    ... How did the idea to study a particular type of stem cell transplant originate? The idea for the study in question is ... occurred with infections and graft rejection because the T cells that come with the transplant must be depleted, or you will encounter ...

    Interview last updated 10/04/2017 - 1:36pm.