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  1. The Challenge of Treating Myelodysplastic Syndromes/Myeloproliferative Neoplasms.

    ... and proliferative features, arising from hematopoietic stem cells . MDS/MPN are neither MDS nor MPN but a distinct World Health ...

    Research Article last updated 09/11/2017 - 8:45am.

  2. Cotransplantation of bone marrow-derived mesenchymal stem cells in haploidentical hematopoietic stem cell transplantation in patients with severe aplastic anemia: an interim summary for a multicenter phase II trial results

    ... Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) for severe aplastic anemia (SAA) ... incidence of graft failure and GvHD. Mesenchymal stem cells (MSCs) have been shown to support hematopoiesis in vivo and ...

    Research Article last updated 02/01/2017 - 12:30pm.

  3. Clinical trial reveals genetic fault that reduces the effectiveness of leukemia treatment

    ... people had a significantly worse outcome if their cancer cells carried a mutation to the CDKN2A gene. The results may help ... involves intensive chemotherapy followed by a stem cell transplant . However high dose chemotherapy is poorly tolerated by ...

    Research Article last updated 09/29/2017 - 10:32am.

  4. Stem Cell Transplantation: What Happens Behind the Scenes?

    ... take a patient all the way from first referral for a stem cell transplant right through the transplant itself. They’re the ... is the part of your immune system that recognizes whether cells it sees in your body belong or not.  Because of the way it is inherited ...

    Interview last updated 01/18/2018 - 1:28pm.

  5. FDA approves first drug to treat GVHD

    ... potentially fatal and common side effect of cancer-related stem cell transplants. The approval covers the use of ibrutinib in patients ... activity of a protein known as BTK, which is present in B cells  and other types of immune cells. GVHD occurs when transplanted ...

    Article last updated 08/29/2017 - 7:55am.

  6. Alina Dulau Florea, MD

    ... Our study involves the analysis of normal and abnormal cells in the bone marrow of patients with Paroxysmal Nocturnal ... defect occurring in early, unspecialized cells called stem cells , located in the bone marrow . These stem cells, ...

    Grant Recipient last updated 01/12/2018 - 9:50am.

  7. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

    ... a rare acquired disorder originating from hematopoietic stem cells and is a life-threating disease characterized by intravascular ...

    Research Article last updated 07/27/2017 - 2:06pm.

  8. Jill Minden’s Encounter with Aplastic Anemia

    ... we learned it did not help me. The time had come for a stem cell transplant . My brothers were not a match for me, but thankfully, ... I took it very hard. My doctor said they harvested enough cells from my donor the first time so we could try again. While waiting for ...

    Patient Chronicle last updated 09/05/2017 - 10:57am.

  9. Sicheng Wen, MD, PhD

    ... Reversal of aplastic anemia by mensenchymal stem cell-derived extracellular vesicles ... in which the body stops producing enough new blood cells. Marrow transplantation, antithymocyte globulin (ATG) treatment ...

    Grant Recipient last updated 01/05/2018 - 1:09pm.

  10. The microenvironment in myelodysplastic syndromes: niche-mediated disease initiation and progression

    ... syndromes (MDS) are clonal disorders of hematopoietic stem and progenitor cells and represent the most common cause of acquired marrow failure. ...

    Research Article last updated 09/13/2017 - 8:25am.