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  1. Novel approaches for myelodysplastic syndromes: beyond hypomethylating agents.

    ... may help select appropriate patients for allogeneic stem cell transplant . A variety of promising new agents are under investigation. ...

    Research Article last updated 10/11/2011 - 5:58pm.

  2. Syngeneic transplantation in aplastic anemia: pretransplant conditioning and peripheral blood are associated with improved engraftment - an observational study on behalf of the Severe Aplastic Anemia and Pediatric Diseases Working Parties of the European

    ... and anti-thymocyte globulin as well as peripheral blood stem cells performed in later years. Ten year overall survival was 93% with ... than not and possibly to prefer peripheral blood as a stem cell source. Bone Marrow ...

    Research Article last updated 08/05/2013 - 9:44am.

  3. Pilot trial of risk-adapted cyclophosphamide intensity based conditioning and HLA matched sibling and unrelated cord blood stem cell transplantation in newly diagnosed pediatric and adolescent recipients with acquired severe aplastic anemia

    ... -based conditioning regimens and allogeneic hematopoietic stem cell transplantation (AlloHSCT) from matched related donors (MRD) has resulted ...

    Research Article last updated 04/09/2014 - 9:11am.

  4. 5-Azacytidine in myelodysplastic syndromes: a clinical practice guideline.

    ... ) who cannot proceed immediately to allogeneic stem cell transplant . 5-Aza is not recommended as first line therapy with MDS ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. Comparison between Matched Related and Alternative Donors of Allogeneic Hematopoietic Stem Cells Transplanted into Adult Patients with Acquired Aplastic Anemia: Multivariate and Propensity Score-Matched Analysis.

    ... anemia (AA) who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) from matched related donors (MRDs), and those ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. Bone Marrow Transplantation for Acquired Severe Aplastic Anemia

    ... to HLA -identical sibling transplants. Recent data on stem cell source, conditioning regimens, and graft-versus-host disease prophylaxis ...

    Research Article last updated 01/20/2015 - 2:47pm.

  7. Optimizing Cord Blood and Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502) (CHAMP)

    ... (OS) separately in the 2 arms at 1 year post-hematopoietic stem cell transplantation (HSCT). ...

    Clinical Trial last updated 12/19/2017 - 7:55am.

  8. The diagnosis and treatment of aplastic anemia: a review

    ... pancytopenia . A trigger-related abnormal T cell response facilitated by some genetic predisposition has been ... (MSD) is not available for transplant. MSD hematopoietic stem cell transplantation (HSCT) is associated with cure in ~90 % of ...

    Research Article last updated 05/26/2015 - 10:30am.

  9. Outcome of Aplastic Anemia in adolescence. A survey of the Severe Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation

    ... comparing (i) matched family donor hematopoietic stem cell transplantation performed as first line treatment with (ii) front-line immunosuppressive therapy not followed by subsequent transplant given for failure and with (iii) Hematopoietic Stem Cell ...

    Research Article last updated 08/21/2014 - 9:39am.

  10. Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH).

    ... Glycan class A (PIG-A) gene in the hematopoietic stem cells (HSC) of patients. The presence of these mutations leads to production of blood cells with decreased GPI-anchored cell surface proteins, making red blood cells (RBC) derived from the clone ...

    Research Article last updated 10/22/2013 - 3:44pm.