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  1. Pilot trial of risk-adapted cyclophosphamide intensity based conditioning and HLA matched sibling and unrelated cord blood stem cell transplantation in newly diagnosed pediatric and adolescent recipients with acquired severe aplastic anemia

    ... -based conditioning regimens and allogeneic hematopoietic stem cell transplantation (AlloHSCT) from matched related donors (MRD) has resulted ...

    Research Article last updated 04/09/2014 - 9:11am.

  2. 5-Azacytidine in myelodysplastic syndromes: a clinical practice guideline.

    ... ) who cannot proceed immediately to allogeneic stem cell transplant . 5-Aza is not recommended as first line therapy with MDS ...

    Research Article last updated 10/11/2011 - 5:58pm.

  3. The diagnosis and treatment of aplastic anemia: a review

    ... pancytopenia . A trigger-related abnormal T cell response facilitated by some genetic predisposition has been ... (MSD) is not available for transplant. MSD hematopoietic stem cell transplantation (HSCT) is associated with cure in ~90 % of ...

    Research Article last updated 05/26/2015 - 10:30am.

  4. Comparison between Matched Related and Alternative Donors of Allogeneic Hematopoietic Stem Cells Transplanted into Adult Patients with Acquired Aplastic Anemia: Multivariate and Propensity Score-Matched Analysis.

    ... anemia (AA) who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) from matched related donors (MRDs), and those ...

    Research Article last updated 10/11/2011 - 5:58pm.

  5. Simona Pagliuca, MD

    ... in which the bone marrow and the hematopoietic stem cells that reside there are damaged. This causes a deficiency of all three blood cell types ( pancytopenia ): red blood cells ( anemia ), white ...

    Grant Recipient last updated 06/08/2017 - 10:43am.

  6. Outcome of Aplastic Anemia in adolescence. A survey of the Severe Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation

    ... comparing (i) matched family donor hematopoietic stem cell transplantation performed as first line treatment with (ii) front-line immunosuppressive therapy not followed by subsequent transplant given for failure and with (iii) Hematopoietic Stem Cell ...

    Research Article last updated 08/21/2014 - 9:39am.

  7. Eltrombopag Added to IST Yields Encouraging Results

    ... current work demonstrates that stimulating remaining stem cells with a drug that mimics the actions of a natural growth ... would respond to the treatment. Telomeres get shorter with cell divisions and may represent how exhausted the bone marrow is prior ...

    Interview last updated 05/24/2017 - 7:44am.

  8. Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH).

    ... Glycan class A (PIG-A) gene in the hematopoietic stem cells (HSC) of patients. The presence of these mutations leads to production of blood cells with decreased GPI-anchored cell surface proteins, making red blood cells (RBC) derived from the clone ...

    Research Article last updated 10/22/2013 - 3:44pm.

  9. Bone marrow versus peripheral blood sibling transplants in acquired aplastic anemia: survival advantage for marrow in all age groups.

    ... has been shown to be superior to peripheral blood, as a stem cell source, in young patients (<20 years of age) with acquired aplastic ...

    Research Article last updated 06/15/2012 - 3:04pm.

  10. Transplantation

     

    Page last updated 01/20/2015 - 4:45pm.