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  1. Stem Cell Transplant Using Peripheral and Cord Blood Stem Cells to Treat Severe Aplastic Anemia and Myelopdysplastic Syndrome

    ... aplastic anemia (SAA) and myelodysplastic syndrome (MDS) are life-threatening bone marrow disorders. For SAA patients, long ... related donor might promote rapid engraftment and reduce TRM secondary to prolonged neutropenia associated with conventional UCBT. This ...

    Clinical Trial last updated 04/25/2016 - 2:18pm.

  2. Efficacy of Oral Azacitidine Plus Best Supportive Care as Maintenance Therapy in Subjects With Acute Myeloid Leukemia in Complete Remission (QUAZAR AML-001)

    ... of de novo AML (Acute Myeloid Leukemia) or AML secondary to prior myelodysplastic disease or chronic myelomonocytic leukemia ... myelodysplastic syndromes (MDS) Associated Drug(s):  ...

    Clinical Trial last updated 04/29/2016 - 8:39am.

  3. Palifermin With Leuprolide Acetate for the Promotion of Immune Recovery Following Total Body Irradiation Based T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation

    ... myelodysplastic syndromes (MDS) Associated Drug(s):  ... t (8;21), t(15;17), inv 16 without c-kit mutations). Secondary AML in remission AML in ≥ 2nd remission ALL in 1st ... t (8;21), t(15;17), inv 16 without c-kit mutations). Secondary AML in remission AML in ≥ 2nd remission ALL in 1st ...

    Clinical Trial last updated 04/29/2016 - 1:11pm.

  4. Vidaza and Valproic Acid Post Allogeneic Transplant for High Risk AML and MDS

    ... stem cell transplantation in patients with high-risk MDS/AML. We hypothesize that adding valproic acid to azacitidine will improve ... In addition to assessing for 1 year survival, we will have secondary objectives of assessing progression-free survival, relapse, and ...

    Clinical Trial last updated 04/29/2016 - 12:35pm.

  5. Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET)

    ... myelodysplastic syndromes (MDS) Phase:  Phase 3 ... (severe, recurrent, requiring medications, and felt to be secondary to the MPN) either after diagnosis or within 10 years before ...

    Clinical Trial last updated 05/02/2016 - 2:31pm.

  6. Phase I/II MAHCT w/ TCell Depleted Graft w/ Simultaneous Infusion Conventional and Regulatory T Cell

    ... myelodysplastic syndromes (MDS) Phase:  Phase 1 ... > 50 cc/min SGPT and SGOT < 2.5 x ULN, unless elevated secondary to disease. Total bilirubin < 2 x ULN (patients with ...

    Clinical Trial last updated 05/09/2016 - 3:58pm.

  7. Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

    ... hemoglobinuria (PNH) or myelodysplastic syndrome (MDS) associated with cytopenias. Patients with BMFS have traditionally been ... primary endpoint of this study will be cGVHD at day 365. Secondary end points include transplant related mortality, engraftment, degree ...

    Clinical Trial last updated 04/28/2016 - 2:40pm.

  8. Pegylated Interferon Alfa-2a Salvage Therapy in High Risk Polycythemia Vera (PV) or Essential Thrombocythemia (ET)

    ... myelodysplastic syndromes (MDS) Phase:  Phase 2 ... (severe, recurrent, requiring medications, and felt to be secondary to the MPN) either after diagnosis or within 10 years before ...

    Clinical Trial last updated 04/29/2016 - 9:59am.

  9. Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

    ... hemoglobinuria (PNH) or myelodysplastic syndrome (MDS) associated with cytopenias. Patients with BMFS have traditionally been ... primary endpoint of this study will be cGVHD at day 365. Secondary end points include transplant related mortality, engraftment, degree ...

    Clinical Trial last updated 04/25/2016 - 10:08am.

  10. Panobinostat With Fludarabine and Cytarabine for Treatment of Children With Acute Myeloid Leukemia or Myelodysplastic Syndrome

    ... acute myeloid leukemia (AML) ormyelodysplastic syndrome (MDS). The purpose of this study is to test the safety of panobinostat and ... patients with relapsed or refractory AML or MDS. SECONDARY OBJECTIVES: Characterize the pharmacokinetics of panobinostat ...

    Clinical Trial last updated 04/29/2016 - 10:11am.