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  1. Only particular cytogenetic events are related to disease progression in sequential cytogenetic studies in myelodysplastic syndromes.

    ... in 76 patients with myelodysplastic syndromes (MDS) followed up to 82 months. Their karyotypes were followed routinely, ... transformation or reduced survival, since the majority of secondary cytogenetic changes in evolutive karyotypes of our patients were ...

    Research Article last updated 07/09/2013 - 3:18pm.

  2. The role of epigenetics in the regulation of apoptosis in myelodysplastic syndromes and acute myeloid leukemia.

    ... to the pathogenesis of myelodysplastic syndromes (MDS) and may trigger disease-progression to secondary acute myeloid leukemia (AML). Expression of apoptosis-mediators FAS ...

    Research Article last updated 11/14/2013 - 11:34am.

  3. Lack of objective response of myelodysplastic syndromes and acute myeloid leukemia to decitabine after failure of azacitidine

    ... are standard therapy for myelodysplastic syndromes (MDS), and are often used to treat patients with acute myeloid leukemia (AML) ... or AML who were treated with decitabine after primary or secondary azacitidine failure at the University of Maryland Greenebaum Cancer ...

    Research Article last updated 10/02/2014 - 10:13am.

  4. Prevalence, severity and correlates of fatigue in newly diagnosed patients with myelodysplastic syndromes

    ... with higher-risk myelodysplastic syndromes (MDS). The secondary objectives were to assess symptom prevalence and to examine the ...

    Research Article last updated 10/27/2014 - 10:22am.

  5. Multicenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: the alternative dosing for outpatient treatment (ADOPT) trial.

    ... of patients with myelodysplastic syndromes (MDS) on a schedule of 15 mg/m(2) administered via intravenous (IV) infusion ... were > or = 18 years of age and had MDS ( de novo or secondary) of any French-American-British (FAB) subtype and an International ...

    Research Article last updated 10/11/2011 - 5:58pm.

  6. CASCADE (SGN33A-005)

    ... cytologically/histologically confirmed de novo or secondary AML according to World Health Organization (WHO) classification ... chemotherapy for antecedent myelodysplastic syndrome (MDS First Name Last Name ...

    Clinical Trial last updated 06/19/2017 - 2:43pm.

  7. Clinical management of gastrointestinal disturbances in patients with myelodysplastic syndromes receiving iron chelation treatment with deferasirox

    ... regular transfusions of packed red blood cells leading to a secondary iron overload which might result in organ damage. Therefore, ... chelator which has been highly efficient in the treatment of secondary iron overload. Most frequent side effects of DFX are gastrointestinal ... myelodysplastic syndromes (MDS) ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. Azacitidine in the management of patients with myelodysplastic syndromes.

    ... Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoeitic disorders characterized ... of tumor suppressor genes in high-risk MDS and secondary leukemias. Hence, the role of irreversible DNA methlytransferase ...

    Research Article last updated 05/14/2013 - 2:48pm.

  9. Clonal diversity of recurrently mutated genes in myelodysplastic syndromes

    ... studies suggest that most cases of myelodysplastic syndrome (MDS) are clonally heterogeneous, with a founding clone and multiple ... 94 candidate genes in a cohort of 157 patients with MDS or secondary acute myeloid leukemia (sAML). This included 150 cases with samples ...

    Research Article last updated 03/05/2013 - 8:30am.

  10. Cytogenetics in benzene-associated myelodysplastic syndromes and acute myeloid leukemia: new insights into a disease continuum

    ... Evidence indicates that acute myeloid leukemia arises as a secondary event, subsequent to evolution of the leukemia-initiating cell ... myelodysplastic syndromes (MDS) ...

    Research Article last updated 04/09/2014 - 9:39am.