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  1. Reduced Intensity Conditioning and Haploidentical Related Bone Marrow for Patients With Hematologic Diseases

    ... Chronic myelogenous leukemia: all types except refractory blast crisis. Large-cell lymphoma, Hodgkin lymphoma and ... after initial therapy if chemotherapy sensitive. Refractory leukemia or MDS These patients may be taken to transplant in aplasia ...

    Clinical Trial last updated 06/06/2016 - 10:54am.

  2. A Phase III, International, Randomized, Controlled Study of Rigosertib versus Physician’s Choice of Treatment in Patients with Myelodysplastic Syndrome after Failure of a Hypomethylating Agent

    ... World Health Organization (WHO) criteria (Appendix 2) or refractory anemia with excess blasts in transformation (RAEB t) ...

    Clinical Trial last updated 11/29/2016 - 8:29am.

  3. Non-Myeloablative Conditioning for Unrelated Donor Umbilical Cord Blood Transplant

    ... Chronic myelogenous leukemia: all types except refractory blast crisis. Chronic phase patients must have failed or been ... for debulking chemotherapy before transplant. Patients with refractory disease are eligible, unless has bulky disease and an estimated ...

    Clinical Trial last updated 05/02/2016 - 2:13pm.

  4. Phase I/II, Study of Selective Inhibitor of Nuclear Export (SINE) Selinexor (KPT-330) + Sorafenib in Acute Myeloid Leukemia

    ... mutated patients 18 years of age or older with relapsed/ refractory AML (any number of relapses) including patients who may have ... of this study. Phase II FLT3-ITD mutated relapsed/refractory patients: Patients should have a diagnosis of AML ( de novo ...

    Clinical Trial last updated 05/23/2016 - 3:37pm.

  5. Shorter Course Tacrolimus After Nonmyeloablative, Related Donor BMT With High-dose Posttransplantation Cyclophosphamide

    ... a purine analog-containing regimen b. Relapsed, refractory , or progressive aggressive non Hodgkin's lymphoma (including ... acute lymphoblastic lymphoma must be in CR. c. Relapsed, refractory, or progressive Hodgkin's lymphoma meeting one of the following ...

    Clinical Trial last updated 05/02/2016 - 2:38pm.

  6. Extended Dosing With Eltrombopag for Severe Aplastic Anemia

    ... on continued cyclosporine administration. Patients with refractory severe cytopenias are at risk of dying from infection or ... which are expensive and inconvenient, Patients with refractory SAA are also at risk for progression to other hematologic disorders, ...

    Clinical Trial last updated 04/26/2016 - 9:36am.

  7. A Biomarker-Directed Phase 2 Trial of SY-1425 in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

    ... the activity of SY-1425 in patients with relapsed/ refractory acute myeloid leukemia (AML) or high-risk myelodysplastic ...

    Clinical Trial last updated 08/24/2016 - 11:20am.

  8. Britta Will, PhD

    ... and improvements in overall survival, relapse and refractory disease continue to occur in some patients. Recent findings ...

    Grant Recipient last updated 07/07/2016 - 9:46am.

  9. T-Cell Replete Haploidentical Donor Hematopoietic Stem Cell Plus Natural Killer (NK) Cell Transplantation in Patients With Hematologic Malignancies Relapsed or Refractory Despite Previous Allogeneic Transplant

    ... with hematologic malignancies that have relapsed or are refractory after prior allogeneic transplant. Toxicity will be evaluated by ...

    Clinical Trial last updated 05/03/2016 - 11:43am.

  10. Study to Evaluate the Safety, Tolerability and Pharmacokinetics of DS-3032b in Hematological Malignancies

    ... Recommended Phase II Dose (RP2D) in subjects with refractory or relapsed Acute Myelogenous Leukemia (AML), Acute ... blast phase, or high risk MDS in Part 1-Dose Escalation and refractory or relapsed AML or high risk Myelodysplastic Syndrome (MDS) in ...

    Clinical Trial last updated 04/29/2016 - 1:50pm.