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  1. A Study of E6201 for the Treatment of Advanced Hematologic Malignancies With FLT3 Mutation (AML)

    ... Cohort 1 will enroll up to 26 patients with relapsed or refractory AML and confirmed FLT3 mutation without prior exposure to a FLT3 ... Cohort 2 will enroll up to 12 patients with relapsed or refractory AML and confirmed FLT3 mutation with prior exposure to a FLT3 ...

    Clinical Trial last updated 05/09/2016 - 4:09pm.

  2. Myelodysplastic syndromes.

    ... are classified as having 1 of 5 subtypes of disease: refractory anemia (RA); RA with ringed sideroblasts (RARS); RA ...

    Research Article last updated 10/11/2011 - 5:58pm.

  3. Dose Escalation of OXi4503 as Single Agent and Combination With Cytarabine w/Subsequent Ph 2 Cohorts for AML and MDS (AML)

    ... intermediate-dose cytarabine in subjects with relapsed/ refractory AML or MDS. Phase 2 will investigate overall response rate ... agent (Arm A) and 2) subjects with relapsed and refractory AML after treatment failure of up to 1 prior chemotherapy ...

    Clinical Trial last updated 05/02/2016 - 11:06am.

  4. Eltrombopag Added to IST Yields Encouraging Results

    ... responded to immunosuppressive therapy (IST). These refractory patients were continuing to require weekly transfusions for ...

    Interview last updated 05/24/2017 - 7:44am.

  5. Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts for the Prevention of GVHD in Children

    ... Acute lymphocytic leukemia in relapse or primary refractory disease with a circulating blast count of no more than 10,000/mm^3 Acute myeloid leukemia in relapse or primary refractory disease with a circulating blast count of no more than 10,000/mm^3 ...

    Clinical Trial last updated 06/13/2016 - 2:29pm.

  6. Selective Depletion of CD45RA+ Naive T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors for Prevention of GVHD

    ... Acute lymphocytic leukemia in relapse or primary refractory disease with a circulating blast count of no more than ... or C only) Acute myeloid leukemia in relapse or primary refractory disease with a circulating blast count of no more than 10,000/mm^3 ...

    Clinical Trial last updated 06/06/2016 - 2:55pm.

  7. Ramon V. Tiu, MD

    ... with aplastic anemia treated with ATG do not respond ( refractory aplastic anemia) and others have an initial response but lose it ... therapies for the treatment of patients with relapsed/refractory aplastic anemia. Alefacept is a novel immunosuppressive agent ...

    Grant Recipient last updated 10/30/2012 - 6:28pm.

  8. Hematopoietic Stem Cell Transplantation in Aplastic Anemia

    ... normal blood counts. Limitations of IST have included refractory disease, relapse and long-term risk of developing ... to excellent survival, the risk of events such as relapse, refractory disease, or clonal progression that we see with IST, was not seen ...

    Interview last updated 11/28/2016 - 2:58pm.

  9. Reduced intensity conditioning and co-transplantation of unrelated peripheral stem cells combined with umbilical cord mesenchymal stem/stroma cells for young patients with refractory severe aplastic anemia.

    Journal Title:  Int J Hematol Primary Author:  Fu Y Author(s):  Fu Y, Wang Q,...

    Research Article last updated 11/26/2013 - 11:14am.

  10. Allogeneic Bone Marrow Transplantation Using Less Intensive Therapy

    ... Myelodysplastic syndrome of all subtypes including refractory anemia (RA) or all IPSS categories if severe ... Criteria (High risk patients on Arm 7) Patients with refractory leukemia or MDS may be taken to transplant in aplasia after ...

    Clinical Trial last updated 05/02/2016 - 2:20pm.