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  1. Optimizing Cord Blood and Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502) (CHAMP)

    ... one trial of immunosuppressive therapy (IST) by being refractory or having relapsed. IST could have included ATG based regimens, ...

    Clinical Trial last updated 05/22/2017 - 11:00am.

  2. Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts for the Prevention of GVHD in Children

    ... Acute lymphocytic leukemia in relapse or primary refractory disease with a circulating blast count of no more than 10,000/mm^3 Acute myeloid leukemia in relapse or primary refractory disease with a circulating blast count of no more than 10,000/mm^3 ...

    Clinical Trial last updated 06/13/2016 - 2:29pm.

  3. Selective Depletion of CD45RA+ Naive T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors for Prevention of GVHD

    ... Acute lymphocytic leukemia in relapse or primary refractory disease with a circulating blast count of no more than ... or C only) Acute myeloid leukemia in relapse or primary refractory disease with a circulating blast count of no more than 10,000/mm^3 ...

    Clinical Trial last updated 06/06/2016 - 2:55pm.

  4. Hematopoietic Stem Cell Transplantation in Aplastic Anemia

    ... normal blood counts. Limitations of IST have included refractory disease, relapse and long-term risk of developing ... to excellent survival, the risk of events such as relapse, refractory disease, or clonal progression that we see with IST, was not seen ...

    Interview last updated 11/28/2016 - 2:58pm.

  5. MEDALIST Trial

    ... (ECOG) score of 0, 1, or 2 5.    Subjects who ar refractory /intolerant/ineligible to prior ESA treatment, defined as: Refractory to prior Erythropoiesis- stimulating agents(ESA) treatment: ...

    Clinical Trial last updated 02/22/2017 - 11:42am.

  6. Ramon V. Tiu, MD

    ... with aplastic anemia treated with ATG do not respond ( refractory aplastic anemia) and others have an initial response but lose it ... therapies for the treatment of patients with relapsed/refractory aplastic anemia. Alefacept is a novel immunosuppressive agent ...

    Grant Recipient last updated 10/30/2012 - 6:28pm.

  7. Allogeneic Bone Marrow Transplantation Using Less Intensive Therapy

    ... Myelodysplastic syndrome of all subtypes including refractory anemia (RA) or all IPSS categories if severe ... Criteria (High risk patients on Arm 7) Patients with refractory leukemia or MDS may be taken to transplant in aplasia after ...

    Clinical Trial last updated 05/02/2016 - 2:20pm.

  8. A Phase III, International, Randomized, Controlled Study of Rigosertib versus Physician’s Choice of Treatment in Patients with Myelodysplastic Syndrome after Failure of a Hypomethylating Agent

    ... World Health Organization (WHO) criteria (Appendix 2) or refractory anemia with excess blasts in transformation (RAEB t) ...

    Clinical Trial last updated 11/29/2016 - 8:29am.

  9. Reduced Intensity Conditioning and Haploidentical Related Bone Marrow for Patients With Hematologic Diseases

    ... Chronic myelogenous leukemia: all types except refractory blast crisis. Large-cell lymphoma, Hodgkin lymphoma and ... after initial therapy if chemotherapy sensitive. Refractory leukemia or MDS These patients may be taken to transplant in aplasia ...

    Clinical Trial last updated 06/06/2016 - 10:54am.

  10. Reduced intensity conditioning and co-transplantation of unrelated peripheral stem cells combined with umbilical cord mesenchymal stem/stroma cells for young patients with refractory severe aplastic anemia.

    ...

    Research Article last updated 11/26/2013 - 11:14am.