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  1. A phase 2 trial of high dose lenalidomide in patients with relapsed/refractory higher-risk myelodysplastic syndromes and acute myeloid leukaemia with trilineage dysplasia

    ... Limited therapies exist for patients with refractory and relapsed (RR) higher-risk myelodysplastic syndromes ...

    Research Article last updated 11/02/2016 - 9:17am.

  2. Increasing the effectiveness of hematopoiesis in myelodysplastic syndromes: erythropoiesis-stimulating agents and transforming growth factor-β superfamily inhibitors

    ... responses are often short-lived. In fact, many ESA- refractory patients harbor defects in late-stage erythropoiesis downstream ...

    Research Article last updated 10/02/2017 - 10:10am.

  3. Persistent elevation of plasma thrombopoietin levels after treatment in severe aplastic anemia

    ... therapy (IST) or IST and eltrombopag; 10 IST- refractory patients who had received eltrombopag only), focusing on ...

    Research Article last updated 10/02/2017 - 9:40am.

  4. Clinical Outcomes in Adult Patients with Aplastic Anemia- a single institution experience

    ... IST regimens in frontline and relapsed/ refractory (R/R) settings. Pretreatment and on-treatment clinical ... prior response to ATG: prior responders (46%) vs primary refractory (0%) (p<0.01). In the R/R setting, there was no survival difference ...

    Research Article last updated 09/13/2017 - 7:40am.

  5. Early treatment initiation in lower-risk myelodysplastic syndromes produces an earlier and higher rate of transfusion independence

    ... by ineffective hematopoiesis resulting in refractory cytopenias. Red blood cell (RBC) transfusions can ...

    Research Article last updated 09/13/2017 - 8:58am.

  6. Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

    ... in treating patients with relapsed or refractory acute myeloid leukemia. An immune cell is a type of blood cell ... enrolled are those patients with active relapsed or refractory CD123+ acute myeloid leukemia (AML) de novo , or ... disease (increased bone marrow blasts ) Refractory AML is defined as patients that have not achieved a CR after 2 ...

    Clinical Trial last updated 07/14/2016 - 4:08pm.

  7. Lenalidomide in lower-risk myelodysplastic syndromes with karyotypes other than deletion 5q and refractory to erythropoiesis-stimulating agents

    ... without del(5q), but its efficacy in patients clearly refractory to erythropoiesis-stimulating agents (ESA) is not known. We ... consecutive lower-risk non-del(5q) MDS patients with anaemia refractory to ESA and treated with LEN in a compassionate programme, 20 of whom ...

    Research Article last updated 04/24/2012 - 2:47pm.

  8. Activity of alemtuzumab monotherapy in treatment-naive, relapsed, and refractory severe acquired aplastic anemia

    ... from 2003-2010 in treatment-naïve, relapsed, and refractory SAA in three separate research protocols at the National ... Primary outcome was hematologic response at 6 months. For refractory disease, patients were randomized between rabbit ATG plus ... in SAA but best results are obtained in the relapsed and refractory settings. The trials were registered at www.clinicaltrials.gov ...

    Research Article last updated 11/16/2011 - 1:57pm.

  9. Alternative donor HSCT in refractory acquired aplastic anemia - Prevention of graft rejection and graft versus host disease by immunoablative conditioning and graft manipulation

    ... H, Müller E, Schwinger W. Alternative donor HSCT in refractory acquired aplastic anemia - Prevention of graft rejection ... IST. Seven patients (median age at diagnosis, 11 yr) with refractory AAA without a MSD underwent HSCT from matched unrelated (n = 6) ...

    Research Article last updated 07/30/2012 - 2:02pm.

  10. Eltrombopag and improved hematopoiesis in refractory aplastic anemia

    ... One third of patients have disease that is refractory to immunosuppression, with persistent, severe cytopenia ... 2 study involving patients with aplastic anemia that was refractory to immunosuppression to determine whether the oral thrombopoietin ...

    Research Article last updated 07/31/2012 - 2:24pm.