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  1. Long-term outcome of fludarabine-based reduced intensity allogeneic hematopoietic cell transplantation for debilitating paroxysmal nocturnal hemoglobinuria

    ... including 8 who were HLA -alloimmunized, underwent a reduced intensity allogeneic hematopoietic cell transplant (HCT). All received ...

    Research Article last updated 06/02/2014 - 11:39am.

  2. Reduced intensity conditioning, combined transplantation of haploidentical hematopoietic stem cells and mesenchymal stem cells in patients with severe aplastic anemia

    ... donor-derived umbilical cord MSCs (UC-MSCs), respectively. Reduced intensity conditioning consisted of fludarabine (30 ... (500 mg/m2·d)+anti-human thymocyte IgG. Transplant recipients also received cyclosporin A, mycophenolatemofetil, and ...

    Research Article last updated 04/09/2014 - 9:16am.

  3. Pilot trial of risk-adapted cyclophosphamide intensity based conditioning and HLA matched sibling and unrelated cord blood stem cell transplantation in newly diagnosed pediatric and adolescent recipients with acquired severe aplastic anemia

    ... been associated with decreased overall survival. Reduced toxicity conditioning and AlloHSCT has been used successfully in other ... transfusions received conditioning regimen with higher intensity cyclophosphamide (200 mg/kg). RESULTS: Seventeen patients ...

    Research Article last updated 04/09/2014 - 9:11am.

  4. Outcomes after Umbilical Cord Blood Transplantation for Myelodysplastic Syndromes

    ... associated with TRM (P=.001), DFS (P=.02), and OS (P=.001). Reduced conditioning intensity was associated with increased risk of relapse (RR 3.95; 95% CI ...

    Research Article last updated 03/22/2017 - 9:24am.

  5. Allogeneic stem cell transplantation in myelodysplastic syndromes: does pretransplant clonal burden matter?

    ... for cytoreductive therapy before transplant, especially if reduced intensity conditioning (alloSCT) is planned. Patients with less than 10% blasts ...

    Research Article last updated 04/29/2016 - 10:22am.

  6. Optimizing stem cell transplantation in myelodysplastic syndromes: unresolved questions.

    ... patient selection, and transplant modifications using reduced conditioning intensity. This review highlights strategies to optimize transplant for MDS ...

    Research Article last updated 10/11/2011 - 5:58pm.

  7. Hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: long-term results of a retrospective study on behalf of the Gruppo Italiano Trapianto Midollo Osseo (GITMO).

    ... (in all cases from identical donor) and 11 were given a reduced intensity conditioning (8 from identical donor and 3 from mismatched donor). ...

    Research Article last updated 10/11/2011 - 5:58pm.

  8. A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies

    ... rate at 2 years post treatment using the Jefferson 2 step reduced intensity conditioning (RIC) approach in patients with haploidentical family ...

    Clinical Trial last updated 04/27/2016 - 1:56pm.

  9. Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndromes - Lingering Uncertainties and Emerging Possibilities

    ... increasing age of allogeneic recipients, introduction of reduced intensity conditioning (RIC) regimens, increased availability of unrelated ...

    Research Article last updated 08/21/2014 - 9:28am.

  10. Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies

    ... efficacy of this approach over the historical 2 step reduced intensity conditioning (RIC) approaches in the "vulnerable" population defined ...

    Clinical Trial last updated 04/27/2016 - 1:37pm.