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  1. Current concepts in the pathophysiology and treatment of aplastic anemia

    ... viewed in isolation as an odd, rare, and invariably fatal blood disease, aplastic anemia is now of substantial interest for its ... of patients. Once relegated to a few presentations in the red cell and anemia sessions of the ASH, the Society now sponsors multiple ...

    Research Article last updated 01/07/2014 - 12:34pm.

  2. Alina Dulau Florea, MD

    ... , some bone marrow cells and their progeny in the blood lack an important cell surface component that functions as an anchor for ... system. The result of this deficiency is a breakdown of red cells. If large quantities of red cells are destroyed, people become very ...

    Grant Recipient last updated 06/08/2017 - 10:39am.

  3. Costs and quality of life in patients with myelodysplastic syndromes.

    Journal Title:  Am J Blood Res Primary Author:  ... most MDS patients become anaemic, so as to require red blood cell transfusions. To investigate the costs and the impact on ...

    Research Article last updated 09/16/2013 - 8:45am.

  4. Paroxysmal nocturnal hemoglobinuria in pediatric patients.

    Journal Title:  Pediatr Blood Cancer Primary Author:  ... failure (N = 10); gross hemoglobinuria with isolated red cell anemia (N = 1); and jaundice, hepatitis, and isolated ...

    Research Article last updated 12/12/2011 - 10:07am.

  5. Outcomes in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with isolated deletion 5q treated with lenalidomide: a subset analysis from the MDS-004 study

    ... mg at 16 weeks, respectively. RESULTS: Rates of red blood cell - transfusion independence (RBC-TI) ≥182 days were ...

    Research Article last updated 07/29/2014 - 12:12pm.

  6. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... glycan anchor (PIG-A) in a multipotent hematopoietic stem cell (HSC), with clonal expansion of the mutated HSC. The mutation causes a ... GPI-linked proteins, are absent from the cell surface of red cells, granulocytes, monocytes, and platelets, resulting in ... hemolysis and other complications. Lysis of red blood cells is the most obvious manifestation, but as other cell lineages are ...

    Research Article last updated 05/14/2013 - 3:28pm.

  7. Simona Pagliuca, MD

    ... there are damaged. This causes a deficiency of all three blood cell types ( pancytopenia ): red blood cells ( anemia ), white blood cells (leukopenia), and platelets ...

    Grant Recipient last updated 06/08/2017 - 10:43am.

  8. Eltrombopag restores tri-lineage hematopoiesis in refractory severe aplastic anemia which can be sustained on discontinuation of drug

    Journal Title:  Blood Primary Author:  Desmond R ... eventually had significant increases in neutrophil , red cell and platelet lineages. Five patients with robust ...

    Research Article last updated 01/07/2014 - 12:22pm.

  9. Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH).

    ... The presence of these mutations leads to production of blood cells with decreased GPI-anchored cell surface proteins, making red blood cells (RBC) derived from the clone more sensitive to ...

    Research Article last updated 10/22/2013 - 3:44pm.

  10. Performance characteristics of consensus approaches for small and minor paroxysmal nocturnal hemoglobinuria clone determination by flow cytometry.

    ... (1%-20%) and minor (<1%) PNH clones within the white blood cell (WBC) and red blood cell (RBC) compartments with sensitivity up to 0.1%. Results: ...

    Research Article last updated 07/09/2013 - 3:33pm.