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  1. Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH).

    ... The presence of these mutations leads to production of blood cells with decreased GPI-anchored cell surface proteins, making red blood cells (RBC) derived from the clone more sensitive to ...

    Research Article last updated 10/22/2013 - 3:44pm.

  2. Costs and quality of life in patients with myelodysplastic syndromes.

    ... Journal Title:  Am J Blood Res Primary Author:  ... most MDS patients become anaemic, so as to require red blood cell transfusions. To investigate the costs and the impact on ...

    Research Article last updated 09/16/2013 - 8:45am.

  3. Conferences, Webinars and Webcasts

    ... MDS   English   Blood and Bone Marrow Basics   English   ... PNH is a rare and serious blood disease that causes red blood cells to break apart. Doctors call this breaking apart " hemolysis ...

    Page last updated 09/30/2014 - 11:50am.

  4. Interviews with the Experts Managing MDS With Supportive Care and Active Treatment

    ... to giving a specific drug or agent that treats the disease. Blood transfusions are the backbone of supportive care for patients with MDS, ... group of agents used is growth factors.  This includes red blood cell growth factors like erythropoietin (Procrit®) or ...

    Interview last updated 09/22/2014 - 12:25pm.

  5. Treatment and outcomes for chronic myelomonocytic leukemia compared to myelodysplastic syndromes in older adults

    ... to Medicare claims. Baseline characteristics, treatment ( red blood cell transfusions, hematopoietic growth factors, hypomethylating ...

    Research Article last updated 11/19/2012 - 2:37pm.

  6. Performance characteristics of consensus approaches for small and minor paroxysmal nocturnal hemoglobinuria clone determination by flow cytometry.

    ... (1%-20%) and minor (<1%) PNH clones within the white blood cell (WBC) and red blood cell (RBC) compartments with sensitivity up to 0.1%. Results: ...

    Research Article last updated 07/09/2013 - 3:33pm.

  7. Eltrombopag now an approved therapy for certain patients with severe aplastic anemia

    ... Eltrombopag, works by helping to increase production of blood cells. According to Cynthia Dunbar, M.D., Head, Molecular ... of patients, the majority multi-lineage [ neutrophil , red cell, and platelets].  In some patients with normalized marrow function, ...

    Page last updated 08/27/2014 - 2:19pm.

  8. The immunomodulatory agents lenalidomide and thalidomide for treatment of the myelodysplastic syndromes: A clinical practice guideline.

    ... expected with the aging population. Treatment includes red blood cell transfusion for anemia . The immunomodulatory agents ...

    Research Article last updated 10/01/2012 - 10:04am.

  9. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... glycan anchor (PIG-A) in a multipotent hematopoietic stem cell (HSC), with clonal expansion of the mutated HSC. The mutation causes a ... GPI-linked proteins, are absent from the cell surface of red cells, granulocytes, monocytes, and platelets, resulting in ... hemolysis and other complications. Lysis of red blood cells is the most obvious manifestation, but as other cell lineages are ...

    Research Article last updated 05/14/2013 - 3:28pm.

  10. How we treat lower risk myelodysplastic syndromes.

    ... Journal Title:  Blood Primary Author:  ... in most cases. Supportive care , mainly red blood cell transfusions, remains an important component of their ...

    Research Article last updated 05/14/2013 - 2:56pm.