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  1. Iodine I 131 Monoclonal Antibody BC8, Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation and Donor Bone Marrow Transplant in Treating Patients With Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or High-Risk Myelodysplastic Sy

    ... they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells ...

    Clinical Trial last updated 04/28/2016 - 1:01pm.

  2. Special Issues for People with PNH

    ... either of these things, it's a good idea to: Get a red blood cell count Get treatment for your anemia (blood transfusions or ...

    Page last updated 01/20/2015 - 4:59pm.

  3. Autoreactive T Cells From Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Specifically Recognize Glycosyl- Phosphatidyl-Inositol (GPI)

    ... there is a lack of certain proteins on the surface of the red blood cells. These proteins (such as CD55 and CD59) normally prevent the red ...

    Research Review last updated 05/02/2016 - 9:26am.

  4. A Rare Genetic Polymorphism in C5 Confers Poor Response to the Anti-C5 Monoclonal Antibody Eculizumab by Nine Japanese Patients with PNH

    ... and inactivates the C5 complement protein and protects the red cell from the pore forming on its surface. This prevents breakdown of red blood cells that occurs in the circulation and turns very dark urine clear ...

    Research Review last updated 05/02/2016 - 9:25am.

  5. The Challenging World of Cytopenias: Distinguishing Myelodysplastic Syndromes From Other Disorders of Marrow Failure.

    ... Research Review: Low blood counts can be attributed to several different medical conditions.  ... failure syndromes, myeloproliferative neoplasms, and pure red cell aplasia. Single-nucleotide polymorphism array karyotyping ...

    Research Review last updated 05/02/2016 - 9:18am.

  6. HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy (RAFA)

    ... dependence* ANC <1000 x 109/L Hgb <8 gm/dl or red cell transfusion dependence* Myelodysplastic Syndrome (MDS) (based ... filgrastim neupogen Biological: Peripheral blood stem cell The source of stem cells for all patients will be ...

    Clinical Trial last updated 05/09/2016 - 3:19pm.

  7. Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation, and Donor Bone Marrow Transplant Followed by Donor Natural Killer Cell Therapy, Mycophenolate Mofetil, and Tacrolimus in Treating Patients With Hematologic Cancer

    ... they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Giving an infusion of the ...

    Clinical Trial last updated 04/29/2016 - 12:48pm.

  8. What is MDS? iPad App

    ... materials provide information about why MDS results in low blood counts, such as anemia (low red blood cell count), neutropenia (low white blood cell count) and ...

    Page last updated 11/01/2013 - 1:25pm.

  9. Duane Draper builds supportive community to help him with MDS and bone marrow transplant

    ... during a  physical, his physician did some routine blood work and discovered that all three of his blood counts were low. ... transfusion as well. Procrit shots increased his red blood cell production while he explored his options for treatment. ...

    Patient Chronicle last updated 09/09/2014 - 10:02am.

  10. What are the treatments for PNH?

    ... your doctor might decide to do nothing but monitor your blood counts if they aren't too low and your symptoms aren't too bad. ... system. This reduces hemolysis , the destruction of red blood cells. Bone marrow/stem cell transplantation (BMT/SCT):  A ...

    FAQ last updated 03/15/2016 - 11:32pm.