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  1. Causes

    ... of substance that helps certain proteins to stick to blood cells. Therefore, any blood cells created by this mutant bone marrow stem ... mutant PIG-A. The abnormal stem cells turn into mature red blood cells that have mutant PIG-A. These are called PNH red blood cells. ...

    Topic section last updated 03/29/2016 - 6:15pm.

  2. Clinical Trials Report for December 2015

    ... marrow failure characterized by a requirement for red blood cell and platelet transfusions. Three different preparative ...

    Page last updated 11/30/2015 - 10:31am.

  3. Andrew Dancis, MD

    ... to progress to leukemia. A characteristic finding in blood cell precursors of some individuals with myelodysplasia is the ringed ... with ringed sideroblasts.  Ringed sideroblasts are red blood cell precursors in the bone marrow that fail to develop normally ...

    Grant Recipient last updated 09/17/2015 - 9:07am.

  4. Clinical Trials Report for January 2016

    ... marrow failure characterized by a requirement for red blood cell and platelet transfusions. Three different preparative ...

    Page last updated 01/07/2016 - 10:57am.

  5. Kathryn (Kate) Bauer, Retired MDS Patient Living Life to the Fullest Since Transplant

    ... and just having fun. Then, in August 2009, I had a blood test and it showed something was off with my white and red blood cells. I had a repeat blood test in September and it improved ...

    Patient Chronicle last updated 07/23/2015 - 9:38am.

  6. Iodine I 131 Monoclonal Antibody BC8, Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation and Donor Bone Marrow Transplant in Treating Patients With Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or High-Risk Myelodysplastic Sy

    ... they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells ...

    Clinical Trial last updated 04/28/2016 - 1:01pm.

  7. Eculizumab

    ... the need for transfusions Reduce the breaking apart of red blood cells ( hemolysis ) over both the short and the long term Reduce ...

    Topic section last updated 03/29/2016 - 7:20pm.

  8. Transplantation Basics

    ... are gathered from either bone marrow , umbilical cord blood, and peripheral blood of a suitable donor and are placed in an MDS ... replacing mature blood cells to treat anemia (from low red blood cell counts) or to increase the platelet count. “Blood ...

    Interview last updated 04/05/2013 - 2:33pm.

  9. Autoreactive T Cells From Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Specifically Recognize Glycosyl- Phosphatidyl-Inositol (GPI)

    ... there is a lack of certain proteins on the surface of the red blood cells. These proteins (such as CD55 and CD59) normally prevent the red ...

    Research Review last updated 05/02/2016 - 9:26am.

  10. A Rare Genetic Polymorphism in C5 Confers Poor Response to the Anti-C5 Monoclonal Antibody Eculizumab by Nine Japanese Patients with PNH

    ... and inactivates the C5 complement protein and protects the red cell from the pore forming on its surface. This prevents breakdown of red blood cells that occurs in the circulation and turns very dark urine clear ...

    Research Review last updated 05/02/2016 - 9:25am.