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  1. Effectiveness of lenalidomide in patients over 75 vs. patients under 75 with RBC transfusion-dependent low/int-1-risk MDS and del5q

    ... with deletion 5q abnormalities who are dependent on red blood cell (RBC) transfusions.  This approval was based on the results of ...

    Research Review last updated 05/02/2016 - 9:32am.

  2. Clofarabine and Melphalan Before Donor Stem Cell Transplant in Treating Patients With Myelodysplasia or Acute Leukemia in Remission

    ... may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Giving clofarabine and melphalan ...

    Clinical Trial last updated 05/03/2016 - 11:55am.

  3. Eculizumab Protects Against TE and Prolongs Survival in Patients with Paroxysmal Nocturnal Hemoglobinuria: An International PNH Registry Study

    ... likely to have thromboembolism were those who had recent red blood cell transfusions, a history of liver problems, and headaches. ...

    Research Review last updated 05/02/2016 - 9:26am.

  4. Safety and Efficacy of Oral Azacitidine (CC-486) Administered in Extended Treatment Schedules to Patients with Lower-Risk Myelodysplastic Syndromes

    ... enrolling patients with lower-risk MDS who need regular red blood cell transfusions, have thrombocytopenia (low platelet ...

    Research Review last updated 05/02/2016 - 9:27am.

  5. EHA S826: Eltrombopag Added to Standard Immunosuppression as First Treatment in Severe Aplastic Anemia

    ... is immunosuppressive treatment. This treatment improves blood cell counts in about 60% to 65% of patients with severe aplastic anemia. ... a median 32 days of treatment. They stopped needing red blood cell transfusions after a median 39 days of treatment. Three ...

    Research Review last updated 05/02/2016 - 9:10am.

  6. More is better: Combination therapies for myelodysplastic syndromes

    ... characterized by ineffective maturation of cells, low blood counts, and risk of transformation to acute myeloid leukemia (AML).  ... alpha in lower-risk MDS patients in an effort to reduce red blood cell transfusion dependence. -The current FDA approved ...

    Research Review last updated 05/02/2016 - 9:14am.

  7. Incidence and Burden of the Myelodysplastic Syndromes

    ... where cells are not maturing properly resulting in low blood counts, increasing the risk of infection, bleeding, and fatigue.  It is ... Medicare costs and require more hospital services.  -Red-blood cell transfusion dependence is associated with increased mortality ...

    Research Review last updated 05/02/2016 - 9:11am.

  8. Myeloablative Unrelated Donor Cord Blood Transplantation With T-Cell Depleted Haplo-identical Peripheral Blood Stem Cells for Patients With High Risk Hematological Malignancies

    ... purpose of this study is to find out whether the addition of blood stem cells from a close family member, when added to two units of ... with life-threatening cytopenia (s), and/or red blood cell or platelet transfusion dependence, or patients with ...

    Clinical Trial last updated 04/29/2016 - 1:33pm.

  9. Total Marrow Irradiation for Refractory Acute Leukemia

    ... and total marrow irradiation before a donor umbilical cord blood or hematopoietic stem cell transplant helps stop the growth of ... may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted ...

    Clinical Trial last updated 05/02/2016 - 9:22am.

  10. T-cell Depleted Alternative Donor Transplantation

    ... severe acquired and congenital cytopenias, white and red blood cell abnormalities, and immunodeficiencies. Patients with acute ...

    Clinical Trial last updated 04/29/2016 - 3:38pm.