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  1. Effectiveness of lenalidomide in patients over 75 vs. patients under 75 with RBC transfusion-dependent low/int-1-risk MDS and del5q

    ... with deletion 5q abnormalities who are dependent on red blood cell (RBC) transfusions.  This approval was based on the results of ...

    Research Review last updated 05/02/2016 - 9:32am.

  2. Myelodysplastic syndromes: What do hospitalists need to know?

    ... Myelodysplastic syndromes (MDS) represent a blood disorder characterized by ineffective production of cells leading to low ... there is a misconception that anemia (a low red blood cell count) is normal in the elderly and that a workup is not ...

    Research Review last updated 05/02/2016 - 9:21am.

  3. Treatments

    ... mature Increase the number of healthy cells in your blood Kill abnormal bone marrow cells  Reduce the number of  ... bone marrow failure diseases to help increase red blood cell , white blood cell or platelet counts. ...

    Topic section last updated 03/30/2016 - 3:13pm.

  4. Incidence and Burden of the Myelodysplastic Syndromes

    ... where cells are not maturing properly resulting in low blood counts, increasing the risk of infection, bleeding, and fatigue.  It is ... Medicare costs and require more hospital services.  -Red-blood cell transfusion dependence is associated with increased mortality ...

    Research Review last updated 05/02/2016 - 9:11am.

  5. More is better: Combination therapies for myelodysplastic syndromes

    ... characterized by ineffective maturation of cells, low blood counts, and risk of transformation to acute myeloid leukemia (AML).  ... alpha in lower-risk MDS patients in an effort to reduce red blood cell transfusion dependence. -The current FDA approved agents ...

    Research Review last updated 05/02/2016 - 9:14am.

  6. Iron Chelation Therapy

    ... body. This can be a problem for people who get lots of red blood cell transfusions. Red blood cells contain iron. Each time you get a ...

    Page last updated 01/20/2015 - 4:40pm.

  7. Specialized Blood Cell Transplants for Cancers of the Blood and Bone Marrow

    ... The are a variety of cancerous diseases of the blood and bone marrow that can be potentially cured by bone marrow ... . The stem cells help to build new functioning bone marrow, red cells, white cells, and platelets. In addition, the immune cells from the ...

    Clinical Trial last updated 04/28/2016 - 2:08pm.

  8. Extended Dosing With Eltrombopag for Severe Aplastic Anemia

    ... Severe aplastic anemia (SAA) is a life-threatening blood disease that can be successfully treated with immunosuppressive drug ... and they require regular platelet and/or red blood cell transfusions, which are expensive and inconvenient, Patients ...

    Clinical Trial last updated 04/26/2016 - 9:36am.

  9. Safety and Effect of GL-ONC1 Administered IV With or Without Eculizumab Prior to Surgery to Patients With Solid Organ Cancers Undergoing Surgery

    ... ); Hemoglobin ≥ 9.0 g/dL(with or without red blood cell (RBC) transfusion); Serum creatinine ≤ 1.5 × upper limit ...

    Clinical Trial last updated 04/28/2016 - 1:57pm.

  10. HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy (RAFA)

    ... dependence* ANC <1000 x 109/L Hgb <8 gm/dl or red cell transfusion dependence* Myelodysplastic Syndrome (MDS) (based ... filgrastim neupogen Biological: Peripheral blood stem cell The source of stem cells for all patients will be ...

    Clinical Trial last updated 05/09/2016 - 3:19pm.