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  1. A Phase 1b/2 Study to Evaluate the Safety and Efficacy of APR-246 in Combination with Azacitidine for the Treatment of TP53 Mutant Myeloid Neoplasms

    ... the Informed Consent (ICF) and is able to comply with protocol requirements. Has adequate organ function according to study protocol guidelines. Age ≥18 years at the time of signing the informed ...

    Clinical Trial last updated 04/21/2018 - 6:04pm.

  2. Haploidentical transplantation for pediatric patients with acquired severe aplastic anemia

    ... aplastic anemia (SAA) have recently improved, but no protocol has been evaluated in a large number of pediatric patients. ... with SAA received haplo-HSCT in our center. The treatment protocol used G-CSF-primed bone marrow with G-CSF-mobilized PBSCs ...

    Research Article last updated 01/24/2017 - 11:52am.

  3. A Phase II Study of the Combination of Azacitidine and Pembrolizumab for Patients with Myelodysplastic Syndrome (MDS)

    ... to give informed consent to comply with the study protocol or to complete the study. Any severe or concurrent disease or ...

    Clinical Trial last updated 05/14/2018 - 1:57pm.

  4. Eltrombopag versus placebo for low-risk myelodysplastic syndromes with thrombocytopenia (EQoL-MDS): phase 1 results of a single-blind, randomised, controlled, phase 2 superiority trial.

    ... and safety. The interim analysis presented here was protocol -specified and used a two-sided significance level of 0·001 and a ...

    Research Article last updated 02/21/2017 - 9:49am.

  5. Marrow grafts from HLA-identical siblings for severe aplastic anemia: does limiting the number of transplanted marrow cells reduce the risk of chronic GvHD?

    ... combined with cyclosporine (CSP). The transplant protocol tested the hypothesis that the incidence of chronic GvHD could be ...

    Research Article last updated 09/13/2016 - 12:50pm.

  6. Optimizing Cord Blood and Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502) (CHAMP)

    ... Search for an unrelated donor and enrollment on this protocol may be abandoned if the clinical situation dictates an urgent ... previously will not be allowed unless approved by the Protocol Chairs and/or Protocol Officer. Alemtuzumab or ATG ...

    Clinical Trial last updated 12/19/2017 - 7:55am.

  7. A Phase III, International, Randomized, Controlled Study of Rigosertib versus Physician’s Choice of Treatment in Patients with Myelodysplastic Syndrome after Failure of a Hypomethylating Agent

    ... to the prohibitions and restrictions specified in this protocol l.  Patients (or, in case of patients who are incapable, the ...

    Clinical Trial last updated 05/04/2018 - 3:53pm.

  8. Clinical Trial Basics

    ... research is done according to a detailed plan known as a protocol . The protocol is carefully designed to safeguard the participants’ health and ...

    Page last updated 01/20/2015 - 4:58pm.

  9. Clinical Trial Basics

    ... research is done according to a detailed plan known as a protocol . The protocol is carefully designed to safeguard the participants’ health and ...

    Page last updated 01/20/2015 - 4:46pm.

  10. Like AAMDSIF, HHS now provides more info on clinical trials

    ... of trial participants, if collected, and the full protocol ; Requiring additional types of adverse event information; and ...

    Article last updated 11/22/2016 - 2:05pm.