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  1. Expanded Access Protocol Using CD3+/CD19+ Depleted PBSC (ExpMACs)

    ... Purpose:  The goal of this protocol is to expand access for patients who lack a fully HLA ( ...

    Clinical Trial last updated 06/13/2016 - 1:47pm.

  2. Foundation Update - August 2017

    ... Unique Aplastic Anemia Protocol at NIH In December 2016 we presented the story of ... to be treated with a particular stem cell transplant protocol. The transplant occurred on August 11 and in coming months, we'll be ...

    Article last updated 09/05/2017 - 10:53am.

  3. In Treatment at NIH

    ... the very first aplastic anemia patient admitted for this protocol , making him the so-called "first in human" test of this particular ...

    Patient Chronicle last updated 06/06/2018 - 10:03am.

  4. A Phase 1b/2 Study to Evaluate the Safety and Efficacy of APR-246 in Combination with Azacitidine for the Treatment of TP53 Mutant Myeloid Neoplasms

    ... the Informed Consent (ICF) and is able to comply with protocol requirements. Has adequate organ function according to study protocol guidelines. Age ≥18 years at the time of signing the informed ...

    Clinical Trial last updated 04/21/2018 - 6:04pm.

  5. A Phase II Study of the Combination of Azacitidine and Pembrolizumab for Patients with Myelodysplastic Syndrome (MDS)

    ... to give informed consent to comply with the study protocol or to complete the study. Any severe or concurrent disease or ...

    Clinical Trial last updated 05/14/2018 - 1:57pm.

  6. Haploidentical transplantation for pediatric patients with acquired severe aplastic anemia

    ... aplastic anemia (SAA) have recently improved, but no protocol has been evaluated in a large number of pediatric patients. ... with SAA received haplo-HSCT in our center. The treatment protocol used G-CSF-primed bone marrow with G-CSF-mobilized PBSCs ...

    Research Article last updated 01/24/2017 - 11:52am.

  7. A Phase III, International, Randomized, Controlled Study of Rigosertib versus Physician’s Choice of Treatment in Patients with Myelodysplastic Syndrome after Failure of a Hypomethylating Agent

    ... to the prohibitions and restrictions specified in this protocol l.  Patients (or, in case of patients who are incapable, the ...

    Clinical Trial last updated 05/04/2018 - 3:53pm.

  8. Optimizing Cord Blood and Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502) (CHAMP)

    ... Search for an unrelated donor and enrollment on this protocol may be abandoned if the clinical situation dictates an urgent ... previously will not be allowed unless approved by the Protocol Chairs and/or Protocol Officer. Alemtuzumab or ATG ...

    Clinical Trial last updated 12/19/2017 - 7:55am.

  9. Eltrombopag versus placebo for low-risk myelodysplastic syndromes with thrombocytopenia (EQoL-MDS): phase 1 results of a single-blind, randomised, controlled, phase 2 superiority trial.

    ... and safety. The interim analysis presented here was protocol -specified and used a two-sided significance level of 0·001 and a ...

    Research Article last updated 02/21/2017 - 9:49am.

  10. Marrow grafts from HLA-identical siblings for severe aplastic anemia: does limiting the number of transplanted marrow cells reduce the risk of chronic GvHD?

    ... combined with cyclosporine (CSP). The transplant protocol tested the hypothesis that the incidence of chronic GvHD could be ...

    Research Article last updated 09/13/2016 - 12:50pm.